ISSN:1096-620X    

DOI:10.1089/jmf.1998.1.1

年代:1998

数据来源: MAL

ISSN:1096-620X    

DOI:10.1089/jmf.1998.1.3

年代:1998

数据来源: MAL

摘要:

Advances in molecular biology now permit the use of plants as vectors for molecularly defined products of human and animal origin. In this review, we summarize the "state of the art" methods currently being used in the research and development of plant-derived material of biomedical importance.

ISSN:1096-620X    

DOI:10.1089/jmf.1998.1.5

年代:1998

数据来源: MAL

摘要:

Garlic(Allium sativutn)is one of the most widely cultivated and consumed herbs in the world. Garlic is also among the most medicinally active substances consumed by people the world over, with documented antimicrobial, antithrombotic, and anticancer activity. The gustatory pleasure derived from spices and pungent plants like onions, leeks, and garlic may derive, in part, from the evolutionary advantages that regular consumption of these foods imparted. This article examines the scientific and clinical data that support the use of garlic as a medicinal food.

ISSN:1096-620X    

DOI:10.1089/jmf.1998.1.13

年代:1998

数据来源: MAL

摘要:

Chemoprevention is currently regarded as one of the most promising avenues for cancer control. The inhibition of the tumor promotion stage in multistage carcinogenesis as a means of chemoprevention. The anti-tumor-promoting activity of numerous methanol extracts from edible Japanese, Thai, and Indonesian plants as well as marine algae was screened with the use of anin vitroassay, the tumor-promoter-induced Epstein-Barr virus activation test in Raji cells. More than 20 active constituents have so far been isolated and identified. Of these compounds, both auraptene, which occurs widely in citrus fruits, and l'-acetoxychavicol acetate (ACA), a major constituent of great galangal (a condiment in southeast Asia), are promising new chemopreventers because of their conspicuous anticarcinogenesis activities in mouse skin, rat tongue, and rat colon. The action mechanisms by which they inhibit carcinogenesis are suggested to be suppression of the generation of Superoxide anions through leukocyte inactivation in the postinitiation (promotion) phase and induction of xenobiotic phase II enzymes in the initiation phase. This review highlights our criteria for advantageous plant selection to discover new types of effective chemopreventers and presents the chemopreventive activities of two functionally novel compounds in rodent models as well as the action mechanisms so far considered.

ISSN:1096-620X    

DOI:10.1089/jmf.1998.1.29

年代:1998

数据来源: MAL

摘要:

Anticancer and antiatherogenic properties of carotenoids have been attributed to their antioxidant effects. However, the antioxidant effect of β-carotene is a controversial topic. There is a great deal of discrepancy betweenin vivoandin vitroactions. One of the major problems ofin vitrostudies using β-carotene is its insolubility in aqueous solutions; this necessitates the use of organic solvents, which drastically limits the use of the solutions in cell culture studies. This paper reports a new method of solubilization of β-carotene in aqueous solution using lyso phosphatidylcholine which permits the preparation of high concentrations of β-carotene. The β-carotene aqueous solution is clear, remains stable for several days, and can be used for cell culture stu

ISSN:1096-620X    

DOI:10.1089/jmf.1998.1.39

年代:1998

数据来源: MAL

摘要:

Cardiovascular disease is the number one cause of death in the United States. Cholesterollowering drugs and dietary and behavioral modifications have been the traditional choice of treatment for the disease. Recently, there has been an increased advocacy for the use of antioxidants to retard the progression of the disease. In this review, the role of oxidants in the promotion of cardiovascular disease and the means by which antioxidants may prevent the disease are outlined. Specifically, multiple pathways by which antioxidants may retard the progression of cardiovascular disease are described.

ISSN:1096-620X    

DOI:10.1089/jmf.1998.1.45

年代:1998

数据来源: MAL

ISSN:1096-620X    

DOI:10.1089/jmf.1998.1.53

年代:1998

数据来源: MAL

ISSN:1096-620X    

DOI:10.1089/jmf.1998.1.57

年代:1998

数据来源: MAL

ISSN:1096-620X    

DOI:10.1089/jmf.1998.1.61

年代:1998

数据来源: MAL