摘要:

SYNOPSISInformation on the prevalence of headache and its characteristic features was collected from an urban population in Zimbabwe, using a combination of interview and questionnaire. Over five thousand people were questioned and the prevalence of headache was found to be 20.2% (17.6% in males and 27.0% in females). Severe headaches were experienced by approximately one third of the headache group and were more common in the younger age groups and in women. One third of the people with headaches had warning symptoms and more than half had precipitating factors. Several other features such as frequency, duration, site, age of onset and treatment sought were studied. The headaches described were classified, the most important finding being the infrequent occurrence of classical migraine.

ISSN:0017-8748    

DOI:10.1111/j.1526-4610.1983.hed2301002.x

出版商:Blackwell Science Inc    

年代:1983

数据来源: WILEY

摘要:

SYNOPSISThe present study dealt with the prevalence of headache generally and migraine in particular among school children. The sample consisted of a total of 3,784 school children, accounting for 94.5% of all grade school pupils aged 13 in two Finnish cities, Tampere and Turku. The data were obtained by use of a questionnaire, filled in by the pupils according to instructions under the supervision of the class's homeroom teacher during class. Headache had occurred during 1980 in 82% of the pupils. In about one‐half (53%) of the pupils it had occurred less than once a month. It occurred monthly in 9% and weekly in 8%. Frequent headache was more common in girls than in boys and was also more commonly paroxysmal in character. Boys had had headaches more often before 1980 than during 1980, whereas in girls headaches had become more common in 1980 than before. Migraine was found to occur for 11.3% of the pupils. It was more common in girls (14.5%) than in boys (8.1%). Classic migraine, in particular, occurred more often in girls. Migraine had ceased to occur prior to 1980 in 24% of cases. In particular those attacks which involved a family history of migraine, visual aura or nausea and/or vomiting had ceased to occur. Migraine too had more commonly ceased to occur in boys (23.3%) than in girls (15.1%). Comparison with previous research showed that the occurrence of migraine had more than doubled during 25 year

ISSN:0017-8748    

DOI:10.1111/j.1526-4610.1983.hed2301010.x

出版商:Blackwell Science Inc    

年代:1983

数据来源: WILEY

摘要:

SYNOPSISSeven‐year‐old children who began school in two large Finnish cities in 1974 were investigated for the occurrence of migraine and other headache; the pupils were again surveyed at the age of fourteen. A total of 2921 pupils participated in both studies. By the age of seven, headache had occurred in 37% and migraine in 2.7%; at the age of fourteen the figures were 69% and 10.6% respectively. In the group under eight years migraine was more common in boys than in girls, but in groups older than that girls were in the majority. The prognosis for migraine which had begun before or at the age of seven was better for boys than for girls, while in girls more often than in boys migraine which began in the early school years disappeared by the age of fourteen ye

ISSN:0017-8748    

DOI:10.1111/j.1526-4610.1983.hed2301015.x

出版商:Blackwell Science Inc    

年代:1983

数据来源: WILEY

摘要:

SYNOPSISThe purpose of the present study was to examine symptom configurations experienced by children with problem headache and to determine whether headache symptoms in children can be analyzed along a continuum of severity. Forty‐seven children between the ages of 8 and 17 years monitored their headache activity on a daily basis for a 3‐week period. The self‐observation data indicated that children did not show a tendency to experience their headache symptoms in terms of distinct muscle contraction and migraine symptom clusters. On the contrary, both categories of symptoms were observed to increase in frequency with increasingly problematic headaches. The presence of both muscle contraction and migraine symptoms increased in a linear fashion with the number of daily headache hours reported by the children during the self‐observation period. The measure of headache hours also correlated significantly with the total number of head pain locations and symptoms reported by the children. A regression analysis revealed that the symptom of nausea with the addition of the symptoms of dull and aching pain, bilateral forehead pain, feelings of tightness and pressure, and light sensitivity accounted for 77% of the variance associated with the severity measure of headache hours. Further support for viewing headaches in children in terms of severity came from an analysis of the time of onset of headache activity characteristic of the different children in the sample. Children with more severe headache activity experienced their attacks at an earlier time of day than children with less severe headache activity. Overall, the self‐observation data provided additional support for the severity model and supported the utility of extending the model to the study of headache disorders in

ISSN:0017-8748    

DOI:10.1111/j.1526-4610.1983.hed2301020.x

出版商:Blackwell Science Inc    

年代:1983

数据来源: WILEY

摘要:

SYNOPSISIn the prophylactic phase of the treatment of migraine the use of beta‐blocking agents has become quite prominent within the past few years.The circulation is responsive in both the internal and the external carotid arteries to beta‐adrenergic neuro‐transmission. It is postulated that beta‐blocking agents would be helpful in preventing vasoconstriction in the internal carotid arteries by inhibiting impulses to beta receptors in the brain; also it would prevent the excessive adrenergic vasodilation in the external carotid arteries. The beta‐adrenergic blockade thus offers an approach to the control of arterial vasodilation during the migraine attack.The purpose of this study is to determine the relative efficacy and safety of nadolol, a new beta‐blocking agent, in reducing the frequency and or, the severity of migraine attacks as compared to placebo.Nadolol competes specifically with beta‐adrenergic receptor antagonists for available beta‐receptor sites. This drug inhibits beta‐1 receptors, which are located chiefly in the cardiac muscle, and beta‐2 receptors, which are located chiefly in the bronchial and the vascular musculature. When access to beta‐adrenergic receptor sites is blocked by nadolol, the chronotropic, inotropic, and vasodilator responses to beta‐adrenergic stimulation are decreased proportionately. Nadolol has no intrinsic sympathomimetric activity, nor does it have an anesthetic‐like membrane stabilizing action.The results obtained in this study, which were very encouraging, are presented, along with the side effects

ISSN:0017-8748    

DOI:10.1111/j.1526-4610.1983.hed2301026.x

出版商:Blackwell Science Inc    

年代:1983

数据来源: WILEY

摘要:

SYNOPSISA photographic pupillometric study has been carried out in 22 migrainous patients, aged between 5 and 17.The pupillary responses to phenylephrine and to fenfluramine in the migrainous patients did not significantly differ from the healthy subjects except at 8th hour during the fenfluramine test.The results are discussed with regard to the hypothesis of a functional deficiency of iris adrenergic innervation.

ISSN:0017-8748    

DOI:10.1111/j.1526-4610.1983.hed2301032.x

出版商:Blackwell Science Inc    

年代:1983

数据来源: WILEY

摘要:

SYNOPSISWe conducted a study of migraine patients under prophylactic therapy to analyse the prognostic significance of some clinical parameters at initial examination. Cases with a duration of illness under 10 years, males and greatest frequency of attacks were correlated with a better outcome.Age at onset and family history of headache had no prognostic value.

ISSN:0017-8748    

DOI:10.1111/j.1526-4610.1983.hed2301034.x

出版商:Blackwell Science Inc    

年代:1983

数据来源: WILEY

摘要:

SYNOPSISThe hypothesis that in migraine, cyclically, an internal environment is established which ‐ beyond a certain point‐of‐no‐return ‐ gives rise to the characteristic attack, led to the evaluation of the feasibility of short‐term prevention of migraine attacks in patients who experience “warning” symptoms several hours before the actual attack. To interfere with the typical vegetative disregulation during the attack the selective dopamine receptor blocker domperidone was used. In a double‐blind cross‐over study 30 mg domperidone, taken at the very first appearance of the warning signals, was clearly superior (p<0.001) to placebo in preventing attacks: the success rates were 66%

ISSN:0017-8748    

DOI:10.1111/j.1526-4610.1983.hed2101037.x

出版商:Blackwell Science Inc    

年代:1983

数据来源: WILEY

摘要:

SYNOPSISDue to its multiple physiologic effects, including interference with vasoconstriction, protection against brain hypoxia, antihistaminic activity and serotonin antagonism, Flunarizine, a calcium channel blocker, is being considered as an agent for the prophylactic treatment of migraine. Twenty patients with classical or common migraine were treated for 2‐6 months with a single nighttime dose of 10 mg of Flunarizine after a 1‐3 month placebo stabilization period in a single blind crossover study. Seventeen patients experienced a statistically significant reduction in headache incidence and/or severity (average reduction 53.3%). No clinically significant changes in laboratory analysis, ECG, or physical examination occurred during the treatment period. Side effects included weight gain, dry mouth, fatigue, sleepiness, muscle aches, and paresthesias, and prompted discontinuation of Flunarizine in three patients. We conclude that Flunarizine may be an effective agent in migraine prophylaxis in certain patients. Its low incidence of generally mild side effects may make it preferable to many of the agents currently in

ISSN:0017-8748    

DOI:10.1111/j.1526-4610.1983.hed2301039.x

出版商:Blackwell Science Inc    

年代:1983

数据来源: WILEY

摘要:

SYNOPSISWe report a patient with severe and refractory facial pain which was dramatically relieved following resection of a bronchogenic carcinoma. We hypothesize that the pain was referred via the vagus nerve.

ISSN:0017-8748    

DOI:10.1111/j.1526-4610.1983.hed2301043.x

出版商:Blackwell Science Inc    

年代:1983

数据来源: WILEY