摘要:

SYNOPSISRecently, three pilot studies have proposed that the addition of products containing aspartame to thediets of migraine headache sufferers may produce a significant increase in the frequency of theirmigraines. The present study was a controlled thirteen‐week, double‐blind, randomized cross‐over studycomparing the effect of aspartame to that of a matched placebo on the frequency and intensity of migraineheadache. The results of this study indicated that the ingestion of aspartame by migraineurs caused asignificant increase in headache frequency for some subjects. The implications of these findings andsuggestions for further research are disc

ISSN:0017-8748    

DOI:10.1111/j.1365-2524.1988.hed2801010.x

出版商:American Association for the Study of Headache/Blackwell Science Ltd    

年代:1988

数据来源: WILEY

摘要:

SYNOPSIS88 patients in need of prophylactic treatment for classical, common or mixed migraine of at least 2years' duration were admitted to a double‐blind placebo‐controlled trial of the beta1‐selective adrenoceptorblocker, metoprolol. All patients initially took placebo for 1 month, during which 29 were excludedprincipally because of failure to reattend or placebo‐response making active treatment unnecessary. Theremaining 59 patients were randomised to continued placebo or metoprolol 50 mg b.i.d. for 2 months.Patients after this time subjectively categorizing their responses as less than optimal changed,double‐blindly, from placebo to metoprolol 50 mg b.i.d., or from metoprolol 50 mg b.i.d. to 100 mg b.i.d., fora further follow‐up period of up to 3 months.Placebo response was 40% overall, and often occurred after the first month. In the first double‐blindcomparative period metoprolol reduced attack frequency significantly, and more than placebo. Severity ofattacks still occurring was not altered by either treatment. Other measures of illness were alteredconsistently with these principal findings. Consistent improvements also were seen in patients switchingfrom initial placebo therapy to metoprolol 50 mg b.i.d. for the further follow‐up period, and those changingto the higher dose of metoprolol showed statistically significant further improvements, and clinicallyimportant improvements overall. Side‐effects were minor and reversible.This study gives supportive evidence of the value of metoprolol in preventing migraine attacks andsuggests that individual dosage titration can substantially enhance its efficacy. Side‐effects do notsignificantly impede its use and other evidence suggests that beta1‐selective blockers are to be preferredover non‐select

ISSN:0017-8748    

DOI:10.1111/j.1365-2524.1988.hed2801015.x

出版商:American Association for the Study of Headache/Blackwell Science Ltd    

年代:1988

数据来源: WILEY

摘要:

SYNOPSISThis report details an acute inflammation of the temporomandibular joint presenting as classicaltrigeminal neuralgia, responsive to anticonvulsant medication. Based upon this case report, we proposethat peripheral stimuli may trigger central trigeminal pain pathways. Peripheral mechanisms of trigeminalhyperexcitability should be excluded when the diagnosis of tic doloreaux is entertained.

ISSN:0017-8748    

DOI:10.1111/j.1365-2524.1988.hed2801024.x

出版商:American Association for the Study of Headache/Blackwell Science Ltd    

年代:1988

数据来源: WILEY

摘要:

SYNOPSISThe presence of headache in Parkinson's disease has been recently reported in the literature. We studied 9cephalalgic parkinsonian patients compared to 8 parkinsonian patients taken as controls, both with clinical rating scalesand with EMG recordings of neck muscles. The presence of psychiatric disturbances was investigated by means ofseveral rating scales. Cephalalgic parkinsonian patients showed greater muscular activity and e higher degree ofanxiety and depression compared to the control group. We suggest the possibility that such factors can account for thecephalalgic condition in these patients.

ISSN:0017-8748    

DOI:10.1111/j.1365-2524.1988.hed2801026.x

出版商:American Association for the Study of Headache/Blackwell Science Ltd    

年代:1988

数据来源: WILEY

摘要:

SYNOPSISShould muscle contraction headache be measured and treated from the traditional bifrontal muscle sites? Fivestudies report significant positive correlations between headache parameters and frontalis surfaceelectromyogram (EMG) levels. In contrast, four sets of authors who analyzed the relationship failed to find asignificant relationship.The purpose of this study is to investigate whether headache and nonheadache EMG levels in chronic musclecontraction headache patients were higher than in nonheadache‐matched controls using both conventional andmore inclusive EMG electrode placement sites.Twenty‐five patients experiencing chronic muscle contraction headache (experimental group) and twenty‐fiveage‐matched nonheadache subjects (control group) comprised this study. Experimental group subjects weremonitored twice while having a headache and twice while not having headache prior to beginning therapy. Datafrom the experimental group were compared with that of the control group who indicated “seldom if everexperiencing headache.” EMG data were collected and statistically compared using the conventional bifrontalmodel, the Cram‐Scan model and a Schwartz‐Mayo profiling method on all persons in this study.Results indicate the Schwartz‐Mayo placement followed by the Cram‐Scan model were superior indisciminating between the headache and nonheadache groups. The most conclusive finding is that the bifrontalplacement model appears antiquated in its ability to provide meaningful diagnostic information and may not besufficient for patient assessment and efficient therapy. Determining the existence of muscle contraction andmodes of treatment may be more effectively reached using multisite EMG monitoring rather than the traditional

ISSN:0017-8748    

DOI:10.1111/j.1365-2524.1988.hed2801030.x

出版商:American Association for the Study of Headache/Blackwell Science Ltd    

年代:1988

数据来源: WILEY

摘要:

SYNOPSISA woman complained of head pain simulating a cluster headache. Atypical features were represented by theabsence of autonomic disorders and the presence of papilledema. A large arteriovenous malformation was found.Vascular mechanisms are hypothesized as the most important factors causing pain in the patient.

ISSN:0017-8748    

DOI:10.1111/j.1365-2524.1988.hed2801036.x

出版商:American Association for the Study of Headache/Blackwell Science Ltd    

年代:1988

数据来源: WILEY

摘要:

SYNOPSISThe aim of the present study was to test the hypothesis that patients whose headaches are usuallypreceded by prodromes would derive more benefits from biofeedback than those who do not have anywarnings. Accordingly, 39 female patients were assigned to either of two conditions: classical migraine(n=17) or common migraine (n=22) depending on the characteristics of their headaches. The classicalmigraine condition included only patients whose headaches were usually or always associated with visualprodromes while thecommonmigraine condition included patients whose headache were never or rarelyassociated with any kind of prodromes. All patients completed 5 weeks of daily self‐monitoring ofheadache activity and medication intake before and after treatment, and at 6‐month follow‐up. Resultsshowed that patients in the classical migraine condition improved significantly more than those in thecommon migraine group. Various explanations for the differential effects of biofeedback in the treatment ofclassical and common migraine are discussed and suggestions for further research are

ISSN:0017-8748    

DOI:10.1111/j.1365-2524.1988.hed2801039.x

出版商:American Association for the Study of Headache/Blackwell Science Ltd    

年代:1988

数据来源: WILEY

摘要:

SYNOPSISIntravenous aspirin (DL‐lysine‐acetylsalicylate; Venopirin(r)) has been available in Japan since 1983. One vial of the agent contains497 mg of aspirin. We have tried the agent to abort or prevent intractable headache and facial pain. Subjects consisted of 15intractable headache and facial pain sufferers, whose diagnoses were based upon clinical criteria at the time of the visit. Thesediagnoses included combined headache 6, common migraine 5, symptomatic trigeminal neuralgia 2, effort migraine I andnon‐migrainous vascular headache 1. One vial of the agent was injected intravenously over 3–5 minutes. The efficacy was judged aseither excellent (complete relief), good (almost complete relief), fair (incomplete relief) or poor (no relief). Of the 15 subjects, 4 patients(common migraine 2, effort migraine 1, and non‐migrainous vascular headache 1) demonstrated excellent responses, and 7 patientswere noted to have good and 4 patients fair responses. In a case of effort migraine intravenous aspirin prevented the attackcompletely. No serious adverse effects were encountered. It is concluded that intravenous aspirin is highly useful for intractableheadache and falcial pain in acute situations. Further clinical trials are worth un

ISSN:0017-8748    

DOI:10.1111/j.1365-2524.1988.hed2801047.x

出版商:American Association for the Study of Headache/Blackwell Science Ltd    

年代:1988

数据来源: WILEY

摘要:

SYNOPSISAfter neuropsychological evaluation, we administered the dexamethasone suppression test to eleven patientssuffering from muscle‐contraction headache and to thirteen patients affected by migraine, in order to verify a possiblecorrelation between a chronic pain such as headache and a cortisolemic response to dexamethasone. None of themappeared to be suffering from depressive syndrome; all patients were DST suppressors. These data suggest that thedexamethasone suppression test does not correlate with chronic pain, but with depression, consistent with the highspecificity of this marker test for depressio

ISSN:0017-8748    

DOI:10.1111/j.1365-2524.1988.hed2801051.x

出版商:American Association for the Study of Headache/Blackwell Science Ltd    

年代:1988

数据来源: WILEY

摘要:

SYNOPSISThe Pain Behavior Questionnaire (PBQ), adapted from an earlier version by Philips and Hunter,1wasadministered to 165 chronic headache patients (migraine, tension, and mixed migraine and tension) duringa pre‐treatment assessment, and asked for a retrospective report of the frequency of engaging in variouspain‐related behaviors during periods of headache. An exploratory factor analysis identifiedfourfactors:avoidance (Factor 1), complaint (Factor 2), non‐verbal complaint (Factor 3), and medication consumption(Factor 4). Additionally, the relationship between behavioral factors and a prospective index of headacheactivity was calculated. In all cases, for the entire sample, and for each diagnostic group, the correlationswere negative, indicating some lack of congruence between a measure of pain and pain behaviors. Finally,the relationship between indices of psychopathology and pain behaviors was assessed utilizing the BeckDepression Inventory (BDI), and the Trait portion of the State‐Trait Anxiety Inventory (STAI). Scores on theBDI were significantly positively correlated with Factors 1, 3 and 4. Scores on the STAI were significantlypositively correlated with all four of the behavioral factors. These results indicate that the pain experiencemay be mediated by factors other than the subjective experience of pain

ISSN:0017-8748    

DOI:10.1111/j.1365-2524.1988.hed2801053.x

出版商:American Association for the Study of Headache/Blackwell Science Ltd    

年代:1988

数据来源: WILEY