ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1974.tb02507.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

AbstractAlprenolol was given to 26 women, participants in a population study, who were found to have arterial hypertension. These women were followed up for about two years, during which period they received β‐adrenergic blocking agents. Except for 6 weeks on placebo and 8 weeks on propranolol, alprenolol was given during the period. Those who had an initial effect from alprenolol also had long‐term benefit of the substance. Blood pressure seemed to remain at the same level during a follow‐up period of two years. Except for one woman who at the end of the two‐year period had slight obstructive bronchial symptoms, which may have been caused by alprenolol, no adverse reactions were seen. After an initial rise when starting treatment with alprenolol serum uric acid values were subsequently normalized and after a two‐year period they seemed to be even lower than the pre‐trea

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1974.tb02508.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

AbstractTwenty patients, known to have essential hypertension, were treated for an average period of 30 months with alprenolol (Aptin®). Initially, the dose reponse to 200 mg up to 800 mg daily was observed. Nine patients were well controlled on alprenolol alone (mean 555 mg daily). The mean decrease at 36 months was 31/21 supine and 28/25 standing in comparison with the initial placebo readings. Ten other patients, who were only partially controlled on alprenolol alone, were eventually well controlled by a combination of alprenolol with either hydralazine or chlorthalidone.No difference was observed in the antihypertensive effects of propranolol and alprenolol in a comparative exercise study on six of the patients.One patient was withdrawn from the study. Side‐effects of transient lassitude occurred in four patients. No signs of bronchial obstruction, postural hypotension or cardiac decompensation were observ

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1974.tb02509.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

AbstractA total of 38 patients aged 61 to 89 years, mean age 72 years, were treated with the β‐adrenergic blocking agent, alprenolol, in a dosage of 400 mg daily for three months. Blood pressure decreased significantly. While the systolic blood pressure decreased to a greater extent during the first week of treatment, the diastolic pressure declined continuously. A significant decrease of heart rate occurred. After one week's treatment signs of congestive heart failure appeared in three patients and were compensated by digitalis in two cases. In one case treatment with alprenolol had to be interrupted. No signs of heart failure after alprenolol appeared later during the treatment. The concomitant use of alprenolol with digitalis, diuretics or oral hypoglycemic agents did not cause any negative interacti

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1974.tb02510.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

AbstractThe antihypertensive potencies of propranolol and alprenolol were compared in a series of 16 patients with essential hypertension using a double‐blind crossover technique. The daily dose of propranolol was 160 mg and that of alprenolol 400 mg. This dose ratio of 1: 2.5 was based on evidence of their equipotency in reducing the heart rate response to isoprenaline and physical exercise.Both compounds reduced significantly the blood pressure and heart rate in supine and erect positions. No statistically significant differences were observed between responses to the two tested compounds. The blood pressure reduction was gradual over a period of three months. Roughly half of the patients was restored to normotension. The use of β‐receptor antagonists in the treatment of hypertension is briefly discu

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1974.tb02511.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

AbstractThe effects of saluretic diuretics, alprenolol and these agents combined have been investigated in 23 patients with mild or moderately severe hypertension. Mean age was 60 years (range 43–75 years).The results of the study show that:Alprenolol in a dose of 426 mg daily gave the same reduction of diastolic pressure as previous treatment with diuretics. In order to achieve the same reduction of systolic pressure a mean dose of 700 mg alprenolol daily was required. The combination saluretic diuretics and alprenolol appears to give re‐inforcement of the antihypertensive effect as combination of 1/4 of the dose of each agent gave equally good control of the blood pressure as the full dose of either agent alone. Some increase of serum uric acid was observed during the treatment with the higher dose of alprenolol. Slight weight gain was observed during all alprenolol periods.Potassium substitution was given only during diuretic periods but despite this the serum potassium levels were higher during treatment with alprenolol. The combination provides a good alternative for the treatment of raised blood press

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1974.tb02512.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

AbstractFifty‐one patients with essential hypertension (WHO stage 1 and 2) were randomly allocated to two groups. One group of 27 patients was treated for six months with chlorthalidone (25 mg) in combination with alprenolol (400–800 mg). The other group, consisting of 24 patients was treated with chlorthalidone combined with α‐methyldopa (750‐1,500 mg). A significant and approximately similar reduction of the blood pressure was observed in both groups. In one patient in the alprenolol group the treatment was interrupted due to inadequate reduction of the blood pressure. Six patients in the α‐methyldopa group discontinued the treatment due to side‐effects. The results indicate that alprenolol is a good alternative to α‐methyldopa when combined with saluretic diuretics in the treatment

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1974.tb02513.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY

摘要:

AbstractSeventeen patients with moderate essential hypertension were included in a double‐blind crossover study, comparing the antihypertensive effect of a combination of alprenolol and hydralazine to that of alprenolol and placebo. Both treatments resulted in a significant decrease in blood pressure compared to initial values. The effects of the combination of alprenolol and hydralazine were significantly more pronounced than those of alprenolol alone.After the crossover study the patients were followed up for 12 months and despite dose reductions of the two drugs in several patients the blood pressure remained virtually unchanged, compared to the values of the crossover study.It is concluded that the combination of alprenolol and hydralazine is a good alternative to other drug treatment in hypertensio

ISSN:0001-6101    

DOI:10.1111/j.0954-6820.1974.tb02514.x

出版商:Blackwell Publishing Ltd    

年代:1974

数据来源: WILEY