ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1980.tb02074.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

SummaryFour patients suffered from chronic or recurrent angioedema, of sudden onset in adult life, associated with visceral pain and impossible to control by dietary means. In spite of normal complement function they respond very well to tranexamic acid therapy. Antiprotease drugs need not be restricted to cases of ClsINH deficiency.

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1980.tb02075.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

SummaryLocal exudation at the sites of allergic and histamine‐induced cutaneous reactions, was measured with anin vivodouble‐labelling procedure, based upon local serial simultaneous measurements of indium‐113 m (113mIn) labelled transferrin and technitium‐99m labelled red blood cells (99mTc RBC). Analyses depended upon the reaction index i.e. comparison of the ratio of113mIn/99mTc counts at the reaction site with the ratio of113mIn/99mTc at the corresponding unreacted site in the skin of the opposite arm.Reaction indices were initially significantly elevated at the sites of histamine and allergic reactions. After the first hour, there was a progressive reduction at histamine sites indicating a tapering of the local accumulation of indium‐labelled transferrin. By contrast allergic reaction sites showed a continuing increase in the reaction index after one hour. During the first hour the curves were comparable, but they diverge and were significantly different after one hour (0.05>P>0.02). This is consistent with the known occurrence of late cutaneous responses at the site of allergic but not histamine

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1980.tb02076.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

SummaryThe presence of castor bean allergens in castor wax products was determined byin vivoandin vitroanalysis of castor wax extracts. Allergens were detected in one extract of castor wax by the PCA reaction in mice, the RAST inhibition reaction, and skin prick test in castor bean sensitive individuals. However, these allergens in the wax were of much lower potency than those in the bean, and were not detectable in a deodorant product utilizing castor wax.

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1980.tb02077.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

SummaryIn ten patients with extrinsic asthma the effects of a new oral chromone FPL57787 and placebo were studied in a random double‐blind fashion to assess the effect of FPL57787 in preventing exercise‐induced asthma (EIA). Exercise testing consisted of steady state running on an inclined treadmill for up to 8 min. FPL57787 gave significant protection (P<0.01) compared to placebo from the maximum percentage fall in FEV1, FVC and MMEF after exercise. FPL57787 also produced a small but significant (P<0.01) percentage increase in FEV1, 2 hr after the drug compared to placebo, whereas no significant increase was seen in FVC or in M

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1980.tb02078.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

SummaryMeasurements by radiometric assay of specific IgE, IgA, IgM, igD and IgG antibodies, in fifty‐six patients with asthma, fifty‐six with rhinitis and twenty with allergic bronchopulmonary aspergillosis (ABPA), showed differences in the patterns of antibody response between the three patient groups, both in terms of levels of class specific antibodies and the proportion of patients giving positive results.Specific IgE antibody values were similar in all three groups and positive results were found in three‐quarters of the patients in each group. No other class of antibody toCandida albicansgave values which were similar in all three patient groups.Specific IgG and IgA antibody values were highest in ABPA and lowest in rhinitis; specific IgM antibody values were highest in asthma and lowest in ABPA; specific IgD antibody values were higher in rhinitis than asthma and very low in ABPA.Specific IgG1 and lgG2 antibodies to C.albicanswere higher in rhinitis than in asthma, whereas specific IgG3 and lgG4 values were significantly higher in asthma than in rhinitis.There was a greater number of positive results for IgG1, IgG2 and IgG4 in patients with ABPA than in the other two patient groups where values for IgG1 and IgG2 antibody toC.albicanswere mainly negative. Positive IgG3 antibody results occurred with greatest frequency in patients with asthma, half of them giving values greater than the mean + 2 s.d. of the control value; positive specific IgG4 antibody values occurred more frequently in asthma than in rhi

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1980.tb02079.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

SummaryA prospective study was made in France to determine the frequency, nature, causes and consequences of systemic reactions occurring during specific immunotherapy. One hundred and fifty five reactions were recorded in 151, 997, injections given to 19,739 patients; a percentage of 0.1. It was higher with pollen extracts (0.2%) and practically nil with other extracts (house dust, Dermatophagoides, insect body, bacteria). Asthma, spasmodic rhinitis and urticaria were the most frequent, 80% of systemic reactions. In 59% no explanation could be found. The main known causes of adverse reactions were excessive doses of antigen, improper timing of treatment or incorrect technique of injection. After appropriate treatment the immunotherapy was continued in nearly 90% of the cases. Specific immunotherapy with the majority of extracts now being used, namely adsorbed extracts, is not dangerous but it must be precisely and cautiously done because errors are responsible for nearly 50% of the recorded systemic reactions.

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1980.tb02080.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

SummaryAn open, parallel comparison of flunisolide and beclomethasone dipropionate nasal sprays is described. Sixty patients entered the study of whom fifty‐six completed the full 4 weeks' therapy. The dosage of flunisolide was two actuations (25 μg/actuation) into each nostril twice a day (total 200 μg). The dosage of beclomethasone dipropionate was one actuation (50 μg) in each nostril four times a day (total 400 μg).Both drugs produced statistically significant improvements compared with admission values in sneezing, stuffiness, runny nose, nose blowing and post‐nasal drip. Both drugs significantly decreased the interference by symptoms with routine life and sleep. At the end of the trial both treatment groups showed total or good control of symptoms in the majority of patients. No statistically significant difference was shown between the effects of the two drugs.Side‐effects did not cause withdrawal from the trial in any patient and were mostly confined to minor headache and nose and throat complaints, in neither treatment group was there any evidence of adrenal suppression or growths of Candida from na

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1980.tb02081.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

SummaryThe prevalence of asthma has been studied in Tokelauan children aged 0–14 years in two environments—Tokelau and New Zealand. Only 11.0% of the 706 children examined in Tokelau were classified as asthmatic, whereas 25.3% of the 1,160 children seen in New Zealand were asthmatic.For those children examined in New Zealand there was no significant difference in the prevalence of asthma between those children who were born in New Zealand and those who were born in Toke

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1980.tb02082.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

SummaryIn an industrial community, Linnavuori, (population 1000) over 100 people developed fever, cough, and dyspnoea 3 to 6 hours after sauna or bathing. This epidemic began in August of 1978 and ended gradually in December. The water source of the community was a small (0.4 km2) lake; in November it was found that the water was contaminated with several bacteria, fungi, and algae. Precipitating antibodies to these bacterial and fungal antigens were not found in the sera of symptomatic patients. To show that tap water, purified by the local waterworks, had provoked the symptoms, four clinically typical patients were each twice challenged. Two of the patients visited their usual public sauna, the two others took a bath at home. Two patients inhaled home tap water aerosol, one inhaled lake water vapor and one home tap water vapor in hospital. Three to six hours after seven of the eight challenges the patients showed two or more of the following symptoms and signs: chills, fever, dry cough, dyspnoea, and inspiratory crepitant râles. Six provocations increased the amount of segmented neutrophils and in each case the lung diffusion capacity decreased significantly. Although the clinical picture resembles extrinsic allergic alveolitis, it is possible that bacterial endotoxins have induced alternative pathway complement activation and release of leukocyte pyrogens.A respiratory syndrome much resembling exogenous allergic alveolitis, and caused by micro‐organism‐contaminated water from air humidifiers and ventilation systems, has become more commonly diagnosed in the 1970's. This disease is also called hypersensitivity pneumonitis or humidifier fever. Banaszak, Thiede&Fink (1970) described four office clerks whose symptoms were shown to be caused by contamination of the office ventilation system by a thermophilic actinomycete. Inhalation tests with the homologous antigen provoked similar symptoms. Finket al.(1971)

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1980.tb02083.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY