摘要:

SummaryFive nurses aged 31–55 years old had a history of asthmatic symptoms after being exposed to psyllium that they prepared and distributed to patients. They had been nurses for 9–20 years and had reported asthmatic symptoms related to work in the past 3–12 months. They reported symptoms of rhinoconjunctivitis and all were atopic but only one had a previous history of asthma. Four of the five tested subjects had an immediate skin reaction to a commercial psyllium extract. All had IgE antibodies to psyllium. At the time that they were investigated, four out of the five had a significant increase in bronchial responsiveness to methacholine (PC 20<8 mg/ml). Inhalation challenges with psyllium caused isolated immediate (one subject) and dual reactions (three subjects). One subject exposed for only 1 min to the psyllium powder experienced a severe immediate bronchospastic reaction, which required intubation for 3 h with complete functional recovery thereafter. This experience illustrates the precautions necessary, with the inclusion of a cautious dose‐response approach, even with an‘occupation‐type’challenge in t

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1987.tb02313.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY

摘要:

SummaryA survey of the house dust mite population was carried out in the homes of fifty asthmatic Liverpool individuals with strongly positive skin tests toDermatophagoides pteronyssinus.As expected,D. pteronyssinuswas the commonest species found. However,Euroglyphus mayneimade up 37% of the total adult mite count and was the predominant species in 48% of beds examined. There was a good correlation between increasing numbers ofE. mayneiand decreasing social class, but only a weak one with percentage relative humidity. Ionic sodium levels in bed dust were found to correlate with decreasing social class and increasingE. mayneilevels. In nineteen beds, mites were sampled at 4‐monthly intervals for 1 year—this showed a relative decrease in the proportion ofE. mayneicompared with other mites in the autumn, when relative humidity was high. A further twenty beds underwent intensive house dust eradication (including the use of plastic covers) for 1 year—these beds showed a progressive fall in the proportion ofE. mayneirecovered, suggesting that this mite is more vulnerable to anti‐house dust mite measures.Euroglyphus mayneiis a common house dust mite and further work needs to be done to assess its antigenic nature and clinical signi

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1987.tb02314.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY

摘要:

SummaryA group of nineteen normally healthy subjects in a microprocessor factory reported various degrees of work‐related respiratory and systemic symptoms that in some were suggestive of humidifier fever (HF). They all had normal serology against a variety of infectious agents, but serum‐precipitating antibody against antigens in the factory humidifier water was present in twelve subjects, primarily those with symptoms most in keeping with HF. There was extensive serological identity between the antigens from this and other confirmed sources of HF. The antibody‐positive subjects were all nonsmokers and had significantly raised serum IgG. Nine months later, following modification of the humidifier system, the symptoms had resolved in fourteen of the nineteen subjects, the precipitins were reduced in seven but persisted in five subjects, and the total IgG levels were significantly reduced in all subjects. The measurement of total, as well as specific, IgG may be of value in assessing this di

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1987.tb02315.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY

摘要:

SummaryThe allergenic cross‐reactivity between storage mites (Lepidoglyphus destructor, Glycyphagus domesticus, Tyrophagus putrescentiaeandAcarus siro) and the house dust miteDermatophagoides pteronyssinuswas studied with the radio‐allergo‐sorbent test (RAST) and the RAST inhibition technique. RAST‐positive sera were obtained from fifty‐three farmers who were positive to at least one of the four storage mites. Sera from twelve of these farmers, eight of whom were also positive toD. pteronyssinus, were investigated with the RAST inhibition technique. No significant correlations were found between IgE‐antibody levels to any single storage mite andD. pteronyssinus.There was no correlation between the RAST results toA. siroandG. domesticus, whereas a significant correlation was found betweenL. destructor, G. domesticusandT. putrescentiae.The RAST inhibition studies confirmed the greater allergenic similarity betweenL. destructor, G, domesticusandT. putrescentiaethan betweenA. siroand the other three storage mites. The results of our studies support the hypothesis that each of the storage mites andD. pteronyssinuspossess their own unique allergen or allergens. Furthermore,L. destructor, G. domesticusandT. putrescentiaeseem to be allergenically more closely related to each other tha

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1987.tb02316.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY

摘要:

SummaryEighty highly atopic patients were selected for study because they had either atopic eczema (fifty cases) or atopic reactivity to foods, as judged by a positive skin‐prick test (thirty cases). In all, sixty‐five out of eighty subjects (81%) described symptoms of some kind provoked by foods, but correspondingly positive skin tests were found in only half of these, thirty‐three out of eighty (41%). The symptoms experienced by thirty‐one of the thirty‐three patients with positive skin tests were immediate in onset (within 1 hr) and were at first confined to the upper gastrointestinal tract, the most frequent symptoms being oral irritation and throat tightness. In a proportion of these patients, further symptoms such as urticaria, asthma or anaphylaxis developed following the initial oral symptoms, which suggested the term‘oral allergy syndrome’. In the absence of the oral allergy, symptoms such as asthma, urticaria, migraine or eczema starting later than 1 hr after food were seldom associated with positive skin tests. In the oral allergy syndrome, the characteristic symptoms (strong association with positive skin tests and RAST, time of onset and sites at which symptoms are expressed) suggest a causative relationship between exposure to food antigens and specific IgE‐induced release of mediators. In cases of food intolerance that lack a characteristic symptom pattern and a positive skin test or radio‐allergo‐sorbent test, it seems appropriate to consider non

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1987.tb02317.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY

摘要:

SummaryAn extract of dust from the outlet filters of a mouse isolator was used as a basis for determining the source of inhalant allergens for subjects sensitive to this species. The antigenic components, identified by crossed immunoelectrophoresis (XIE), were compared to those found in extracts of other mouse‐derived source materials, i.e. urine, fur, dander and saliva. Of the eight dust components, one (Ag 1) was identified as antigenically identical to the major urinary pre‐albumin whilst the others were detected in fur, and to a lesser extent dander and saliva. None of the dust antigens was detected as a component of food or bedding.Crossed radio‐immunoelectrophoresis (XRIE), performed using sera from a group of fifteen mouse‐allergic subjects (positive by RAST to mouse extracts), identified seven of the dust antigens as IgE‐binding components. Antigens 1 and 3 were reactive with all the sera tested and have, therefore, been termed the‘major’allergens. Varied responses were obtained to the other‘minor’antigens.Ag 1 (urinary pre‐albumin) and Ag 3 were detected in all samples of mouse dust studied. RAST and RAST inhibition also indicated the presence of urinary prealbumin. These findings suggest that the major mouse inhalant allergens may be derived predominantly from urine and secretions originating in the skin and

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1987.tb02318.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY

摘要:

SummaryThirty‐one patients with isocyanate‐induced asthma were studied 6–54 months after diagnosis. Four had the same work conditions and unchanged or worse respiratory symptoms; seven had an alternative job or safer work conditions at the same workplace and suffered from mild to severe symptoms. The remaining twenty subjects were definitely removed from exposure; of these, ten (50%) remained symptomatic after being removed from exposure for an average of 19 months. Asymptomatic patients appeared to be younger and to have shorter durations of total and symptomatic exposures, while symptomatic patients were more reactive to acetylcholine at diagnosis. For patients removed from isocyanate exposure and for those re‐employed at the same work‐place, quality of the new work site seems to play a role in the evolution of isocyanate‐ind

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1987.tb02319.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY

摘要:

SummaryHistamine‐induced suppressor cell function was measured in a group of twenty‐five hay fever suffers and sixteen non‐atopic controls. No difference was found in the suppression index between sufferers and controls. There was, however, a significant relationship between the suppression index and nasal sensitivity to grass pollen, whether measured pre‐ or post‐season, but no correlation between specific or total IgE levels and the suppression index. Histamine‐induced suppressor cell function may influence pollen sensitivity in the most sensitive subjects, but not via an effect on IgE

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1987.tb02320.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY

摘要:

SummaryA single dose double‐blind crossover study was performed to compare the efficacy of nedocromil sodium (4 mg) and placebo administered from pressurized aerosols against bronchoconstriction induced by the inhalation of ultrasonically nebulized distilled water (fog) in twelve asthmatic subjects. Neither active nor placebo pre‐treatment produced any significant change in baseline FEV1and SRaw. Nedocromil sodium significantly attenuated fog‐induced falls in FEV1(P<0.001) and increased specific airways resistance (SRaw,P<0.01). The results provide further evidence of the potential therapeutic usefulness of nedocromil sodium in the management of chronic obstructive airways di

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1987.tb02321.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY

摘要:

SummaryA passive cutaneous anaphylaxis test (PCA) for determination of the allergenicity of bovine whey proteins and peptides was developed in mice. Antisera against whey proteins raised in rabbits and in mice, using a procedure for high IgE titre mixed with Freund's incomplete adjuvant, were applied intradermally, and various whey proteins and whey protein hydrolysates were tested for positive PCA reaction. Unhydrolysed whey and peptides larger than 6500 Da were found to react positively, peptides between 6500 Da and 3400 Da reacted weakly, whereas peptides smaller than 3400 Da were unable to initiate a reaction. The studies indicate that guinea‐pigs, widely used by tradition, may be successfully replaced by mice in determination of the allergenicity of various compounds. The sensitivity of the two species is similar, but the husbandry and handling of mice is more convenient, and they are less expensiv

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1987.tb02322.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY