摘要:

SummaryPreliminary investigation suggests that some asthmatic patients find it difficult to synchronize the release of a metered dose from a pressurized aerosol with the correct phase of inspiration. An automatic device has been developed to overcome this problem. Information is presented outlining the physical characteristics of the unit and the methods used to establish its performance in patients. It is suggested that the device may have a place in the management of asthma.

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1976.tb01406.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

SummaryLymphocyte reactivity to pigeon antigens was demonstrated in a patient with severe symptomatic pigeon breeder's disease (PBD). The reactivity of the lymphocytes declined subsequent to cessation of exposure to antigen and in parallel with clinical improvement. Lymphocyte reactivity was also demonstrated in another patient with PBD, in a pigeon breeder with no evidence of PBD, and in a laboratory investigator with a history of exposure to birds other than pigeons. Lymphocyte reactivity in the latter subject increased following cutaneous injection of pigeon serum with the development of delayed‐type cutaneous reactivity. Although lymphocyte reactivity to pigeon antigens may be a necessary immunologic feature for production of PBD, this reactivity does not occur only in symptomatic subject

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1976.tb01407.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

SummaryMaterials associated with the induction of farmer's lung were incubated with fresh normal human serum in the presence of magnesium ethylene glycol tetra‐acetic acid (MgEGTA) or ethylene diamine tetra‐acetic acid (EDTA) and results compared with material known to activate the alternative pathway of complement—zymosan. Results show thatMicropolyspora faeniorganisms are as active as zymosan in reducing complement (C) levels in the presence of MgEGTA, with a 50% reduction in CH50 at approximately 140 μg/ml.Thermoactinomyces vulgarisorganisms produced a 50% CH50 reduction at approximately 1.25 mg/ml and two samples of respirable mouldy hay dust (MHD) at approximately 5.6 mg/ml whereas extracts ofM. faeniandT. vulgarisreduced the CH50 titre by 17% and 39% respectively at 16 mg/ml in the presence of MgEGTA. Organisms and extracts did not reduce the CH50 titre in the presence of EDTA even at the maximum concentration quoted by more than 3%, thus it is considered that alternative pathway activation was responsible for C utilization in the presence of MgEGTA.Respirable MHD used less than 4% available C at 4 mg/ml in the presence of EDTA but at 8 mg/ml dust 11% and 28% available CH50 were used compared with 79% and 81% respectively in the presence of MgEGTA. The elution of immunoglobulin binding material from MHD may be responsible for apparent CH50 consumption in the presence o

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1976.tb01408.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

SummaryIncrease of serum IgE with frequent localization of IgE in the germinal centres, mast cell hyperplasia in lymph nodes and changes of specific granules in the infiltrated eosinophils, such as roughness of the matrix and appearance of tubular structures together with fusing and disappearance of the core, were demonstrated in eosinophilic granuloma of the soft tissue, so‐called Kimura's disease, in association with increase ofanti‐CandidaIgE antibody.It is suggested that this disease may be due to atopic allergy toCandida albic

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1976.tb01409.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

SummaryImmediate, type I, prick test reactions in man to purified fractions ofCandida albicansgroup A were mediated by different classes of antibody. The allergens were the cell‐wall polysaccharide, mannan, and a ‘purified’ cytoplasmic protein fraction, free of mannan, prepared by passage through Sepharose‐concanavalin‐A. Passive transfer tests in the monkey gave immediate reactions, (1) to the purified, cytoplasmic, protein mediated by heat‐labile long‐term sensitizing antibody, and (2) to the polysaccharide, mannan, mediated by heat‐stable short‐term sen

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1976.tb01410.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

SummarySerum IgE was estimated in 226 healthy children aged 0–14 years without obvious atopic disease in their first degree relatives. A paper disc radioimmunoassay technique (PRIST) was used. A number of criteria for selection of cases were established. This led to the exclusion of forty‐two potentially atopic children. The remaining group of 184 children is considered representative of normal children and may therefore be used for reference purposes. The IgE levels were found to be lower than in previous investigations, and this is attributed to the refined technique and the method of select

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1976.tb01411.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

SummaryAlthough clinical reports on the prevalence of summer hay fever in different parts of Europe have been published, comparative studies on atmospheric pollen concentrations appear to have been rarely undertaken. The present paper describes observations on the grass pollen content of the air at Bologna, Brussels, London, Munich and Strasbourg and is the first of a series involving international collaboration between workers in cities of the European Economic Community*.

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1976.tb01412.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

SummarySerum levels of total and specific immunoglobulin E (IgE) have been determined by radioimmunoassays in sixty‐nine allergic subjects. The forty‐one subjects with mild symptoms were the most difficult to diagnose, since nine had IgE levels less than 50 U/ml and nineteen had no detectable specific IgE antibodies. Samples of nasal secretions were collected from these nineteen subjects and five were found to have specific IgE antibodies, and in a further eight increased amounts of total IgE. The possibility of locally produced IgE antibodies should therefore be considered when usingin vitrotests to diagnose mild or recently acquired allergies, especially when serum IgE levels are less than 50 U

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1976.tb01413.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

SummaryThe radioallergosorbent test (RAST) has been adapted to measure specific IgE antibodies in bloodstains. By incubating several allergen discs simultaneously with one stain extract, an allergy profile can be readily obtained from less than 50 μl of dried blood

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1976.tb01414.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

SummaryThe prevalence of immediate positive reactions to prick testing with house dust mite (Dermatophagoides pteronyssinus) and grass pollen allergens was determined in a random sample of 303 children aged between 8 and 14 years from two Southampton schools. One hundred and two (33.7%) showed positive reactions, fifty to bothD. pteronyssinusand grass pollen, thirty toD. pteronyssinusonly and twenty‐two to pollen only. Allergic symptoms were present in fifty‐one of the 102 children with positive skin tests; amongst thirty children withD. pteronyssinusskin sensitivity by itself, only six had symptoms suggestive of allergic disorder. Significantly more children with positive than with negative tests were reported by their parents to have suffered from recurrent bronchitis during early childh

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1976.tb01415.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY