摘要:

SummarySix workers with a diagnosis of occupational asthma and one with chronic bronchitis were examined for sensitivity to epoxy resin systems and certain of their components. In six cases the chemical agent responsible for their symptoms was identified by careful inhalation challenge testing, simulating their exposure at work and thus providing a precise aetiological diagnosis. In one worker asthma followed exposure to triethylene tetramine fume; four were sensitive to acid anhydrides, three to phthalic acid anhydride as a fume or powder and one to trimellitic anhydride. One worker thought to be sensitive to toluene di‐isocyanate gave negative reactions to this and positive reactions to a phthalic acid anhydride epoxy resin and another thought to have asthma from acid anhydride fumes was found to be sensitive only to toluene di‐isocyanate. Immediate, non‐immediate or combined asthmatic reactions were eli

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1977.tb01418.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

SummaryA patient with occupational asthma caused by phthalic anhydride is described. Inhalation challenges under laboratory control produced immediate and delayed asthmatic responses. Repeat exposure to phthalic anhydride after treatment with cromolyn sodium showed inhibition of the late but not the early bronchoconstrictive, asthmatic response.

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1977.tb01419.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

SummarySera from 204 patients with acute or former reactions following penicillin treatment were investigated by RAST with specificity for benzylpenicilloyl and phenoxymethyl‐penicilloyl. The IgE antibody levels were followed up for of more than 2 years. Positive results could be observed at the time of the acute reactions and the weeks following; later on the amounts of specific IgE decreased, with negative RAST results after months or years in many cases. Occasionally negative RAST results occurred within 30 days; on the other hand high levels of specific IgE persisted for years in some patients. Total serum IgE measured by RIST and the RAST results showed similar patterns, with mean levels of 568 u/ml between 0 and 30 days after the penicillin allergic reaction, 286 u/ml between 30 days and 1 year, and 195 u/ml in cases after 1 year corresponded well with the observed decline in specific IgE.Skin tests performed with penicilloyl‐polylysine in 118 patients showed an overall correlation of 91.5% with the RAST results. Differences between the two test systems were observed in patients with a long interval between the test and the last allergic attack. None of the patients with proved penicillin allergy had atopic diseases or a history of atopy.On the basis of these findings it is suggested that the determination of both circulating specific IgE and total IgE should be of great value for diagnostic purposes during acute drug reactions and in the months immediately afterwa

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1977.tb01420.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

SummaryA total of 476 patients with respiratory allergy were interviewed to establish whether the season of birth influenced the type of allergy experienced. Patients with perennial symptoms did not differ from the general population of the U.K. in the distribution of their months of birth. Patients with summer seasonal symptoms attributable to grass pollen sensitivity were more likely to have been born in December to February than in August to November. This trend was most significant in female patients who did not have associated perennial symptoms and who developed symptoms early in life. Other significant differences were also noted between groups of patients complaining of the same symptoms. More males than females had summer seasonal symptoms whereas more females than males had perennial symptoms. Patients who had both perennial symptoms and summer seasonal exacerbations had a higher incidence of a positive family history of atopy and developed symptoms earlier in life than those patients who had summer seasonal or perennial symptoms only.

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1977.tb01421.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

SummaryTwenty‐four patients with chronic urticaria resistant to conventional therapy were treated orally with terbutaline, a specific β2stimulant. This therapy was much more effective than antihistamines. At the dose of 1.25 mg three times a day, there were few side effects. The efficacy was independent of the IgE levels; it seemed greater in idiopathic cases than in cholinergic or pressure induced urticar

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1977.tb01422.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

SummaryThree antigenic preparations were obtained from a non‐capsulated strain ofHaemophilus influenzaeby ultrasonic disintegration, hot phenol extraction and from a fluid culture. They were designatedH. influenzaecytoplasmic antigen (H(1–5));H. influenzaecell wall antigen (HCW); andH. influenzaeculture filtrate antigen (HCF).Studies showed that H(1–5) antigen contained heat stable and heat labile components. The heat stable fraction stained positively for polysaccharide, had a positive limulus lysate test and there was immunological cross‐reactivity between this and heat stable fractions of HCW and HCF. Limulus lysate assay indicated the presence of endotoxin in HCW and HCF preparations.Heat stable as well as heat labile antigens ofH. influenzaeshould be given consideration in future studies regarding the pathogenicity of this organism in the lower respiratory tree. The specificity of the heat stable antigen ofH. influenzaeneeds to be det

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1977.tb01423.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

SummaryThe effect of Paragerm spray from either a hand pressurized can or from a general room mist device (MCR device) on mattress mite populations was compared with the effect of a control spray. After 1 month a reduction in mite population due to the cleaning procedures was evident in the control treated mattresses; Paragerm treated mattresses had significantly fewer mites, notably those treated with the aerosol can spray, nine out of fifteen of which were mite free. Dissection of the mattresses showed that some mites survive and they could form the nucleus from which reinfestation could occur.

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1977.tb01424.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

SummaryTwo allergen pools of commercial detergent enzymes were prepared as skin test reagents: (1) Carlsberg type, composed of three products containing subtilopeptidase A, and (2) BPN type, composed of two products containing subtilopeptidase B and α‐amylase.In 100 non‐exposed controls a reaction suggesting primary irritancy was found at protein concentrations greater than 1 μg/ml intradermally or 1 mg/ml by prick test. Intradermally at 10 μg/ml weals were accompanied by less pronounced flare reactions than observed in specifically sensitized enzyme workers. At 100 μg/ml the reactions were like strong specific reactions. False positive prick test reactions occurred irregularly at 10 mg/ml. In 100 sensitized enzyme workers, reactions were elicited at concentrations from 1.0 to 10‐5μg/ml intradermally and from 1000 to 1 μg by prick test. Intradermal and prick tests correlated well (rs= 0.84,P<0.001). Ratings of symptom severity upon exposure obtained from questionnaires were significantly correlated with skin test reactivity (P<0.01). RAST performed on sera collected simultaneously also correlated significantly with symptom scores. PCA tests in monkeys were less sensitive.Standardized test reagents allow diagnostic skin testing by either intradermal or prick test inB. subtilisenzyme sensitive patients. A clear distinction between primary irritant reactions and true sensitization was made on the basis of the concentration required to elicit

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1977.tb01425.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

SummaryThe effect of a corticosteroid drug on type I reactions in the nose was studied in eighteen hay fever patients. They were treated with a daily dosage of 800 μg beclomethasone dipropionate intranasally for 1 week, in a double‐blind, placebo‐controlled cross‐over trial. Allergen challenge on the last day of each treatment period showed that steroid treatment diminished sneezing and rhinorrhoea, but the effect was not statistically significant (P= 0.10). Immediate nasal blockage was unaffected. There is a marked discrepancy between the minor protection offered by beclomethasone dipropionate in type I allergy, as suggested in this study and the marked efficacy of the drug in the treatment of hay fever. It is suggested that two factors may account for this discrepancy. First, the significance of ‘delayed’ reactions for hay fever symptoms. Second, the difference between a single allergen provocation and continuous exposure. It is suggested that a slight steroid inhibition of immediate reactions following allergen provocation is potentiated during natural exposure due to inhibition of the priming of the

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1977.tb01426.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

SummaryPurified house dust allergen has been employed for screening the susceptibility to inactivation of haemolytic complement in the blood serum of atopic children and control subjects. Fluid phase complement in the control group of children was more sensitive to allergen‐induced inactivation than observed in a normal adult population. Though the mean complement sensitivity indices in all groups of patients were below the value for the control group, there was considerable statistical overlap. The serum complement sensitivities were in no way related to the clinical manifestations. The results of the complement test were not correlated to the total IgE levels, the RAST scores nor the skin reactions with house dust allergen.Some evidence for thein vivoinvolvement of the complement system in childhood atopic allergy was provided: the mean C3proactivator level was significantly lower in atopic children, than in the control group; the mean C4level in children with bronchial asthma and in children with atopic dermatitis was significantly depressed.A significant positive correlation between the serum C4levels and allergen–complement sensitivities in children with both bronchial asthma and atopic dermatitis was obser

ISSN:0954-7894    

DOI:10.1111/j.1365-2222.1977.tb01427.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY