摘要:

Within 1–4 days after kidney transplantation mononuclear cell infiltration developed in rabbit homotransplants. The early cells aggregated around interlobular vessels and gradually infiltrated the cortex during the next few days, spreading predominantly through inter‐tubular connective tissue. Swelling of endothelial cells lining medium sized vessels was noted and in transplants surviving for more than 10 days these vessels showed intimal proliferation. Glomerular changes were not prominent. A few immunoglobulin‐containing cells could be detected by fluorescence microscopy in most of the transplants at the time of rejection. The morphological changes are compared with observations made by others, and differences in the results of immunofluorescence studies are pointed out. It is concluded that the results of immunohistological investigations are not comparable as long as no standardization of immunofluorescence reagents and methods e

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1971.tb00505.x

出版商:Blackwell Publishing Ltd    

年代:1971

数据来源: WILEY

摘要:

A 47‐year‐old man with clinical manifestations of hyperparathyroidism was shown to have a parathyroid adenoma which in light‐microscopy chiefly consists of oxyphilic cells and transitional forms of chief cells and oxyphilic cells. Electron‐microscopy shows that the oxyphilic cells contain tightly packed mitochondria and that the transitory cells are rich in mitochondria. In these latter cells there are signs of stimulated protein synthesis. It is probable that these cells produce the excess of parathyroid hormone. Oxyphilic cells would seem to be developed from the chie

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1971.tb00506.x

出版商:Blackwell Publishing Ltd    

年代:1971

数据来源: WILEY

摘要:

Damaged mesenteric arterioles from rats made hypertensive with intravenous injections of angiotensin showed a production of Van Gieson positive connective tissue which was proportional to the infiltration of mononuclear cells (lymphocytes and monocytes). Rats treated with antithymocyte serum before hypertensive damage of the arterioles showed no or only a very sparse cellular reaction and corresponding to this decreased cellular reaction no production of connective tissue fibrils was observed. As some fibroblast‐like cells contained carbon particles in their cytoplasm it is highly probable that they were transformed lymphocytes and/or monocytes, which had phagocytized carbon particles from the hypertensively damaged arteriole

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1971.tb00507.x

出版商:Blackwell Publishing Ltd    

年代:1971

数据来源: WILEY

摘要:

Hypertensive vascular disease was studied in acute experimental angiotensin induced hypertension. If the hypertension was induced in rats pretreated with injection of thoracic duct lymphocytes the quantity of the mononuclear inflammatory cellular reaction in the damaged arterioles was 2–9 times higher and more prolonged than in control rats. This difference in the cellular reaction is in agreement with the cellular reaction in cases of hypersensitivity of the delayed typ

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1971.tb00508.x

出版商:Blackwell Publishing Ltd    

年代:1971

数据来源: WILEY

摘要:

On comparison of histological qualities in two consecutive series of liver biopsies all exhibiting cirrhosis and fatty change, one with and one without Mallory bodies, the morphological activity (measured by the number of disintegrated liver cells and inflammatory reaction) is found convincingly greater in the series with Mallory bodies. While the degree of cirrhosis measured by the degree of fibrosis is not significantly different in the two series, the degree of destroyed architecture is more pronounced in biopsies with Mallory bodies. The possible reasons for this difference are discussed.

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1971.tb00509.x

出版商:Blackwell Publishing Ltd    

年代:1971

数据来源: WILEY

摘要:

Mast cells in the periosteal callus of healing experimental fractures in rats were shown to incorporate35S‐Iabelled substances. During the first two weeks after fracture,i. e.the organic phase of repair, the uptake of label reached a maximum. As mineralization of the fractures proceeded, the labelling became less intense and the total number of mast cells decreased. It is discussed whether the mucopolysaccharides of the mast cells undergo metabolic changes in the process of repai

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1971.tb00510.x

出版商:Blackwell Publishing Ltd    

年代:1971

数据来源: WILEY

摘要:

Thymus weight and cortico‐medullary size ratio were studied at autopsy in 49 infants between two weeks and two years and a half of age, who died either from sudden unexpected and unexplained death (SUD), or from accidents or other explained non‐infectious causes (ACC), or from acute infections of less than two weeks' duration (ILL). Thymus weight was slightly lower in the SUD group than in the ACC group. Approximate normal curves for absolute and relative thymus weights and for cortico‐medullary ratio as estimated from planimetric measurements on histological sections were drawn on the basis of the combined SUD and ACC groups. Thymus weights and ratios in the ILL group were expressed as per cent of the normal curves and related to the duration of disease. Cortico‐medullary size ratio showed less individual variation than thymus weight and may give a more useful estimate of the functional state of the organ. When disease has lasted for from one to two days, thymus weight and cortico‐medullary ratio may or may not be within normal range. When disease has lasted for more than two days, the values are below normal range. Little or no significant deviation from normal can be expected when disease has lasted for less than 8

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1971.tb00511.x

出版商:Blackwell Publishing Ltd    

年代:1971

数据来源: WILEY

摘要:

Following treatment with phenylbutazone the acute inflammatory response to subcutaneous transplants‐of Ehrlich carcinoma cells was shown to be biphasic. It is suggested that both phases of the inflammatory response may be a sequel to immunological lysis of the tumour cells by humoral antibody and complemen

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1971.tb00512.x

出版商:Blackwell Publishing Ltd    

年代:1971

数据来源: WILEY

摘要:

A case of advanced heart amyloidosis with rupture of the right ventricle is reported.

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1971.tb00513.x

出版商:Blackwell Publishing Ltd    

年代:1971

数据来源: WILEY

摘要:

At different stages of gestation, 104 mice were treated with fluorodeoxyuridine (FUDR). 34 pregnant mice served as controls. The experimental mice were examined at varying intervals after the FUDR injection. At term, the young exhibited the malformations of the limbs and skull so well‐known after administration of FUDR. In addition, there was an increased number of resorptions. 24 hours after the injection on the 9th—12th day of gestation, vascular dilatations and fresh haemorrhages were found at the sites of predilection of malformations. Foetuses removed 2 or more days after the injections showed characteristic, saccular haematomas in the limbs and tail as well as flat, widespread haematomas in the skull. At increasing intervals after the injections, the haematomas decreased in number and were rarely present in foetuses at term. As the number of haematomas decreased, the number of malformations increased. Daily laparotomies, from the 12th to the 18th day, on 5 mice treated on the 11th day with FUDR revealed extremity haematomas which disappeared on the 13th—18th day. Electron microscopic pilot studies of 2 foetal limbs showed, 24 hours after the injection of FUDR, red blood cells in an extra‐vascular situation. The control mice had 354 normal foetuses and 8 per cent spontaneous resorptions. This study, which was a screening experiment, showed that FUDR induces vascular injury with haemorrhages and formation of haematomas, resulting in congenital malformations. The vascular injuries are interpreted as the primary action of FUDR on the cellula

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1971.tb00514.x

出版商:Blackwell Publishing Ltd    

年代:1971

数据来源: WILEY