摘要:

Primary isolated nodular pulmonary amyloidosis is a rare condition of unknown aetiology. The disease runs a benign course but offers a diagnostic problem since it often simulates neoplasm. A case is reported in which the initial diagnosis of a suspected squamous cell carcinoma was made on the basis of material obtained by transthoracic needle biopsy. Lobectomy was performed and the histopathological and histochemical examinations gave the diagnosis of amyloidosis. Re‐examination of the aspiration biopsy material demonstrated the possibilities of making a cytological diagnosis of amyloidosi

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1970.tb02122.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

摘要:

1. Intravenous injection of anti‐angiotensin II causes a transient fall in the mean blood pressure ofanaesthetized normal rats, showing that the angiotensin content in the blood plays a role for the normal blood pressure level. The subsequent return of the blood pressure to its initial level is probably caused by the cardio‐accelerator and pressor reflexes. The function of the baroreceptors is also thought to be the cause why a depressor effect of anti‐angiotensin is lacking inconscious normalrats. Lack of effect onanaesthetized nephrectomizedrats conforms to the lack of angiotensin in their blood. The somewhat increased depressor response to anti‐angiotensin in rats withacute severe constrictionof the renal arteries and the still more pronounced response in many (but not all)renal hypertensiverats conforms to increased plasma angiotensin in these rats. The somewhat decreased depressor response of ureterligated rats corresponds to their decreased sensitivity to angiotensin and renin. 2. Anti‐angiotensin causes adecreased response to injected angiotensinboth in conscious normal and anaesthetized normal, nephrectomized, ureterligated and renal hypertensive rats, the sensitivity in several cases being reduced to less than 1 per cent. If angiotensin iscontinuously infusedin doses of 9 ng/min, anti‐angiotensin will cause a fall of the blood pressure which in one half of the cases reaches the initial level, in the other half stops at a level above the initial, even when a second dose of anti‐angiotensin is injected. When anti‐angiotensin is given between two periods of continuous infusion of angiotensin, the second rise in blood pressure will be smaller, being up to 50 per cent of the first. 3. Anti‐angiotensin causes adecreased response to renin, but the above‐mentioned groups of rats do not react in the same way. In anaesthetizednormalrats the sensitivity is reduced to about 5 to 10 per cent.Nephrectomizedandureterligatedrats are still able to react with a pressor response to doses of renin which are without effect on the blood pressure of anti‐angiotensin pretreated normal rats. The maximum response of rats belonging in these two groups is, however, only up to 50 per cent of that found in non pretreated nephrectomized or ureterligated rats. If given shortlyafterrenin, anti‐angiotensin injection will cause a rapid fall in the blood pressure to the initial level in normal and ureterligated rats, while there is only a partial return to a level markedly above the initial

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1970.tb02123.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

摘要:

The relevant literature on the occurrence of epithelioid‐cell granulomas without a demonstrable infectious genesis in malignant systemic diseases—in particular Hodgkin's disease—is briefly reviewed. Six cases of Hodgkin's disease with epithelioid‐cell granulomas are reported and the aetiology discussed. It is concluded that a consistent explanation of the phenomenon is not afforded by the material available up t

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1970.tb02124.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

摘要:

Two cases of proliferative myositis are described with gross and microscopic photographic reproductions. It is stressed that the condition, which is benign, should not be confused with sarcoma.

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1970.tb02125.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

摘要:

One hundred and fourteen colon specimens were examined in order to analyse how often a number of previously defined pathological‐anatomical findings, with relation to morbus Crohn and ulcerative colitis, were present. By different combinations of the histological findings, the material was divided. Groups, based on wide and narrow definitions of the two diseases, were made. It was shown that a varying number of specimens could not fit into the groups, and—if not very limited criteria were used—some specimens disclosed signs of both diseases. When the macroscopic findings were related to the histological groups the number of specimens in the groups were always reduced. Transmural inflammation, an important sign of morbus Crohn, was divided in two parts: Focal lymphocyte collections and diffuse transmural inflammation. It was demonstrated thatdiffusetransmural inflammation fits better with findings usually accepted as characteristics of ulcerative colitis than with characteristics of morbus Crohn. A similar reasoning was carried out with a group of fissure shaped ulcers designated horizontal fissures. It was suggested that transmural inflammation and fissure shaped ulcers may have been differently interpreted in the literature, thereby being responsible for the reported differences in the ratio between morbus Crohn and ulcerative colitis. If the occurence of granulomas, transmural arranged focal lymphocyte collections and fistulas justify the diagnosis morbus Crohn, this disease could be demonstrated in a smaller or larger part of the colon in 29 out of the 114 patients (25 per

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1970.tb02126.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

摘要:

Male weanling rats were supplied a standard mixed diet (SIFF Norsk Standard) and were given tap water containing 0.02 ppm of F (control group) or water containing 45 ppm of F (fluoridated group) for 4 weeks. At this time the right hind leg of all animals was paralysed by severing the sciatic and femoral nerve. The rats were then continued on the same food and water regimen for 3 weeks. The specific gravity, ash weight and calcium content of the dry, defatted femora were measured. The differences in ash and calcium content in the paralysed and the normal legs were found to be similar in both groups. In the fluoridated animals, however, the normal limbs showed significantly higher mean values of ash content and specific gravity than the corresponding legs of the control animals. The mean ash content of the paralysed limbs of the fluoridated animals was slightly higher, and the mean calcium content and specific gravity were similar to the values observed in the normal limbs of the control animals. Apparently, the high fluoride intake was associated with an increased rate of bone formation, eliminating the effects of disuse atrophy of bone in the paralysed femora.

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1970.tb02127.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

摘要:

On the second day after the removal of a part of an adult rat's kidney mass, a mitotic wave is released among the tubule cells of the remaining kidney. This wave proceeds synchronously throughout the cortex and may be followed by a second but much smaller wave on the third day. The removal of increasing amounts of kidney tissue (a half, a whole or a kidney and a half) is paralleled by the release of mitotic waves of growing size. The peak of a larger wave occurs sooner after the resection than that of a smaller wave. The bisection of a kidney initiates more cell divisions than those expected by the diminution of kidney mass alone. This increase of the mitotic wave appears not to be caused by the presence of the transectional wound. As a working hypothesis it is proposed that the bisection leads to a relative increase in blood flow through the diminuted organ, thereby affecting a more effective drainage of growth‐inhibitor(s) and a corresponding enhancement of the mitotic wave. This latter is always preceded by a non‐mitotic period of slightly less than 30 hr. It is proposed that about the first 2/3 of this period may be taken for the inactivation of an organ‐specific growth inhibitor that suppresses the growth of the convoluted tubules of the intact adul

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1970.tb02128.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

摘要:

The high degree of synchronization of the mitoses produced in the kidney cortex during the second day after the resection of a kidney and a half formed the basis of a method for the estimation of the mitotic time in vivo. The latter was obtained directly as the span of time between the maxima of an early part of the prophase and of late telophase. On an average the mitotic time of the epithelial cells of the convoluted tubules was 44 min.

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1970.tb02129.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

摘要:

A case of rhabdomyosarcoma of the right atrium is presented. Fits of dyspnoea and cyanosis, provoked by postural changes, and pulmonary embolism were the most typical symptoms. Abnormal features were: the long history and the unspecific findings at auscultation and x‐ray examination. Histologically the part of the tumour contiguous with the atrial wall was composed of fairly well differentiated rhabdomyoblasts, while the part protruding into the atrium was anaplastic and necrotic. There were multiple pulmonary emboli, which originated from the anaplastic par

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1970.tb02130.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY

摘要:

An analysis is made of the patterns of bacterial endocarditis in a Norwegian autopsy material from the period 1939–67. This material is compared with that of Harbitz from 1894–97. The main findings include a decreased frequency, an increased average age, a greater variety of aetiologic agents, a lesser importance of rheumatism as predisposing factor, and a very high incidence of embolic phenom

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1970.tb02131.x

出版商:Blackwell Publishing Ltd    

年代:1970

数据来源: WILEY