摘要:

A case of simultaneous occurrence of a thymoma and Hodgkin's disease of the thymus is described.

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1980.tb02458.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

A scoring system for judging the aggressiveness of basal cell carcinomas of the head and neck is devised, based upon 258 tumours from 123 patients. This system is discussed, and we suggest using the depth of growth, the degree of palisading and the narrow epithelial strand formation (narrow strands) as a scoring basis. It is shown that tumours located on the ear are more aggressive than tumours in other places. Tumours on the nose often recur, even though their histological picture is not that aggressive. This phenomenon is also discussed. For proper scoring, an excisional biopsy should be performed unless the tumour is very small. Recurrent tumours and tumours treated with X‐ray also have a higher scor

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1980.tb02459.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

The effect on the growth and spread of tumours by methoxy‐substituted glycerol ethers incorporated into the feed has been tested on a broad spectrum of tumour‐host systems. Inhibitory effects on tumour growth were noted mainly by 1‐0‐(2‐methoxy‐hexadecyl) glycerol and on Melanoma B16, Lewis Lung Tumour, MCA‐sarcoma MCG101 and the lymphomas LAA and P1534. Spontaneous metastasis formation from Melanoma B16 and two MCA‐sarcoma

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1980.tb02460.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

Inner ear disease is extremely rare in the old English sheepdog. The present case would constitute the second known case in Scandinavia and the first one observed in Norway. The morphological investigation revealed complete degeneration of the organ of Corti. A single layer of cells was covering the anatomical location of the stria vascularis. The dog did not show clinical signs of vestibular dysfunction. Hair cells were present in the cristae ampullares and macula utriculi. The histopathological features support a genetic basis for the sensorineural hearing loss, though other (rare) causes of exogenically induced inner ear degeneration cannot be completely excluded on the morphological findings alone. The brain revealed signs of chronic meningitis.

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1980.tb02461.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

The ultrastructure of plasma cells from 65 consecutive bone marrow specimens from 13 patients with multiple myeloma is described. Biopsies were taken from 12 of the patients prior to and after initiation of treatment. The study was undertaken with the aim of correlating ultrastructural characteristics of the myeloma cells with biochemical and clinical parameters, including the survival time after treatment of the patients with cytostatics. Intranuclear inclusions were only seen in the cells of four patients, all of whom had rather long survival times. Two of these are still alive and, furthermore, their plasma cells are characterized by a low mean number of mitochondria in each sectioned cell studied,i.e.7 and 14, respectively. Nuclear bodies were found in about 7 per cent of the plasma cells in biopsies taken before treatment was initiated. During treatment this percentage increased significantly to about 16 (2P = 0.004). A nuclear/cytoplasmic asynchrony was a characteristic feature of the ultrastructure of the myeloma cells. During treatment a significant increase from 34 to 54 per cent (2P = 0.03) was observed in the number of plasma cells with slight asynchrony. No correlation could be established between any ultrastructural features and the values obtained with clinical tests considered of major prognostic significance at the time of diagnosis,e.g.the concentrations of serum creatinine, haemoglobin, serum albumin and serum calcium.

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1980.tb02462.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

Female pigs, fed diets in which 42% of the caloric intake came from either rapeseed oil, fish oil, partially hydrogenated fish oil, partially hydrogenated soybean oil or lard, were killed after one week, five weeks, six months and one year. Type of fat or length of feeding did not affect the cardiac content of total fat which was normal in all animals. The fatty acid pattern of tissue triglycerides only partly reflected the fatty acid pattern of diets. The relative amounts of C22:1 and C20:1 were greatest after six months and levelled off during the following six months. The content of C22:1 in cardiac triglycerides never exceeded one fifth of the dietary concentration. Microscopic lipidosis was found in some pigs after one week, five weeks and six months. Minor heart lesions consisting of focal necrosis of muscle cells were found after one week and more frequently after six months and one year. No relationship between incidence and severity of the heart lesions and any particular type of fat in the diet could be found.

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1980.tb02463.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

The occurrence of CEA was studied by radioimmunoassay and the triple‐bridge immunoperoxidase technique in tissues of human fetuses and by radioimmunoassay in fetal and maternal serum. The antiserum to CEA was extensively adsorbed to eliminate cross‐reactions with CEA‐related antigens. After the first trimester of pregnancy CEA was found throughout the gastrointestinal tract by both techniques, whereas the other fetal tissues and fetal serum did not contain detectable amounts of CEA. The CEA‐level of all 69 sera of pregnant women was below 2.5 ng/ml. The excretory nature of CEA was suggested by the localization of CEA in the luminal border of the alimentary tract and by the finding that the CEA concentration in the content of fetal gastrointestinal canal was higher than in the surrounding tissue. Gel filtration on Sepharose 4B showed that molecular weight of CEA immunoreactive material of the fetal gut was similar to that of CEA purified from colon cancer, but a minor component with a higher molecular weight was eluted in the void volume. When tested in radioimmunoassay, the CEA immunoreactive material in both peaks gave an inhibition curve parallel to that of purif

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1980.tb02464.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

Cartilage and fibrous capsular tissue from the hip joints of 30 unselected autopsies have been examined for the presence of congophilic substance with green dichroism (CS‐GD). Ninety‐three per cent of the cases had CS‐GD in the joint cartilage and 43 per cent contained amyloid deposits in the capsule. The relation of these substances to age and the relation of CS‐GD to the upper and lower parts of the femoral head cartilage have been studied, as well as the inter‐relationship between the presence of CS‐GD in the cartilage and amyloid deposits in the capsule within

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1980.tb02465.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

On histologic and statistic basis a new classification of ductal breast carcinoma is proposed. One group consists of five types, representing different stages in a continuous progression from tubular carcinoma to pure »ductal« type. Another group is comprised by invasive »comedo« carcinoma which is derived from intraductal carcinoma. The development of tubular carcinoma from sclerosing lesions is stres

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1980.tb02466.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

The distribution of chondroitin sulphate and keratan sulphate in osteoarthritic cartilage is analysed in a histochemical study, using Safranin O, Alcian Blue‐CEC and Toluidin Blue O at different pH values. The material consisted of six femoral heads obtained during replacement surgery from patients with osteoarthritis and six control femoral heads from patients who were operated on because of either fracture or tumour. The heterogeneous distribution of glycosaminoglycans in the matrix of cartilage from the osteoarthritic and control patients is described. In addition to the depletion of glycosaminoglycans, which first was seen at the surface, osteoarthritic cartilage was characterized by increasing territorial staining of chondroitin sulphate, especially around the cell clusters. This was a constant finding, even in cartilage with only slight osteoarthritic changes. In the control patients, this phenomenon was found only in the weightbearing area in very old cartilage, or in cartilage with morphological signs of osteoarthritis. Finally, the cartilage of osteophytes contained practically only chondroitin sulphate. These histochemical findings are in accordance with the increase in the rate of35SO4incorporation despite the loss of glycosaminoglycans in osteoarthritis, as described by others, and they reflect probably an accelerated synthesis of glycosaminoglycan

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1980.tb02467.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY