摘要:

Ultrastructural morphology of the rabbit aortic intima is described for areas demarcated or not demarcated by spontaneousin vivouptake of the azo dye Evans Blue. Intimal foci taking up Evans Blue are characterized by endothelial and subendothelial cells showing various degrees of degenerative changes, appearance of young cells and subendothelial fibromuscular thickening. It is concluded that dye uptake is a marker for regions subjected to hemodynamic ‘stress’ due to turbulence or increased flow load, and that the morphologic changes in normal animals are part of appropriate regeneration processes which keep the artery functionally intact. Such foci may represent predilection areas for atherogenesis in pathological situations, such as hypertension or hypercholesterole

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1981.tb00179.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

Mycoplasma contamination of cultured cells may cause considerable interference with their behaviour and metabolism. Whether or not mycoplasma are actually taken up by cells in vitro has long been a matter of dispute. In the present study mycoplasma were shown to be phagocytosed by feline lung fibroblasts and to end up in the lysosomal vacuome of the cells, where the organisms were only partially degraded by the hydrolytic enzymes leading to a rapid (within a few days) accumulation of secondary lysosomes of the residual body variety. It is thus obvious that studies on the structure and function of the lysosomal vacuome in cultured cells are possible only if precautions are taken to avoid that the cultures become contaminated by mycoplasma.

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1981.tb00180.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

Various types of mineral dust can induce interstitial pulmonary fibrosis, but there is no definite correlation between lung X‐ray findings, tissue lesions and the type of dust. In this paper, we report on the post mortem verification of talcosis by lung tissue analysis, using light microscopy, scanning electron microscopy, energy dispersive x‐ray microanalysis and x‐ray diffracto

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1981.tb00181.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

Thirty‐nine severely calcified aortic valves surgically removed were studied for amyloid deposits using the alkaline Congo red stain. Amyloid deposits were found in all the valves, in such quantities that they could be demonstrated using screening magnification (X 40). A close topographic relationship was found between amyloid and calcium deposits. In addition, histological evidence was found of prolonged fibroblast proliferation. In the light of more recent studies, which identify Congophilic cytofilaments in fibroblasts, as well as demonstrating fibroblast degeneration and decomposition in senile aortic valves, the following pathogenesis is suggested for “calcific aortic stenosis”; Mechanical injury of malformed aortic valves leading to fibroblast proliferation; fibroblast degeneration and decomposition with extracellular accumulation of cellular degradation products (among others Congophilic cytofilaments); calcium deposits in the cellular degradation products resulting in “calcific aortic st

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1981.tb00182.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

The ultrastructure of a complex membranous structure, the labyrinth, is described. This structure was found in bone marrow plasma cells from patients with multiple myeloma as well as from other groups of patients. It is concluded that the labyrinth may represent a rare route of secretion by which plasma cells are able to excrete waste products and simultaneously secrete intracellularly synthesized material.

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1981.tb00183.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

The detailed localization of early atherosclerotic lesions in arterial bifurcations was studied in 33 brachiocephalic arteries obtained from autopsies of young persons who had suffered a violent and sudden death. Drawings of the sudanophilic lesions in the vessel wall were fed to a computer, scaled to a standardized size and shape, and added together. The results are presented as contour lines connecting points with equal frequency of early lesions. The distribution of the early lesions reveals a distinct pattern: The early lesions start to develop on the outer walls of the bifurcation, while the inner walls downstream from the flow divider are kept free as are also the lateral walls. These results are clearly in conflict withFry'sshear stress hypothesis, while they seem to supportCaro'shypothesis of inhibition of local diffusional transport. The results are also at variance with results obtained in most animal models, suggesting that the process which takes place in the vessel wall in these animals may be different from human atherosclerosis.

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1981.tb00184.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

The morphology of two cases of prolactin (PRL) secreting pituitary tumours was analyzed at the light and electron microscopic level. Prior to surgery both patients had been treated with bromocriptine. In both tumours, groups of cells revealed considerable morphological changes but these were not confined to the whole adenoma. In fact, most cells still appeared ultrastructurally intact. Pieces from both adenomas were explanted to anin vitrosystem. These specimens secreted mainly PRL though smaller amounts of growth hormone (GH) were also produced. The cell morphology of the cultured specimens often showed a large number of preserved cells.

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1981.tb00185.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

In order to determine the incidence of different morphological types of thyroid cancer in the Nordic countries, all cases of thyroid cancer reported to the national cancer registries of Finland, Iceland, Norway and Sweden over periods ranging from 1 to 14 years were re‐examined (a total of 706 cases) by one or two pathologists from each country. The age‐adjusted incidence rate for Iceland was clearly higher than those for the other Nordic countries. The rate for Finland was the lowest, and a five‐fold difference was seen between Iceland and Finland. The differences in the incidence rates applied to all age groups and to both sexes. The differences also concerned all histological types and were most pronounced for papillary and medullary carcinomas. In papillary carcinoma, an almost 10‐fold difference was found between Finland and Iceland. The causes of the differences are not known. There has been and probably still is some endemic goitre in Finland, Norway and Sweden, but no endemic goitre occurs in Iceland. Thus, no positive association was found between the presence of endemic goitre and the risk of follicular carcinoma. There was a marked negative association between endemic goitre and the risk of papillary ca

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1981.tb00186.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

A single intraperitoneal injection of Compound 48/80 in rats causes mast cell activation which is followed by a proliferation in fibroblasts and mesothelial cells in the mesentery. The same is true of organ‐cultured rat mesentery, but in cultured guinea‐pig mesentery Compound 48/80 has no morphological effects on mast cells and does not induce proliferation. The relationship between mast‐cell secretion and cell proliferation in surrounding cells was studied further in the investigation now presented. Proliferation was estimated (a) by cytophotometric Feulgen DNA measurements in individual fibroblast and mesothelial cell nuclei; (b) by measurements of incorporation of3H‐TdR into DNA; (c) and by estimation of mitotic frequency. Mast‐cell secretion was studied morphologically and by biochemical quantitation of histamine release. Compound 48/80 is a potent mast cell activator in the rat, stimulating mast cells to secretion. The results of this study suggest that Polymyxin B, another powerful mast‐cell activator, apparently chemically unrelated to Compound 48/80, also stimulates the mesenterial cells to proliferation in the rat. In the guinea‐pig Compound 48/80 does not induce mast‐cell secretion or proliferetion in fibroblasts and mesothelial cells in the mesentery. The results give further evidence that the cell proliferation induced by Compound 48/80 and Polymyxin B in rat mesentery is causally related to mast

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1981.tb00187.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

In 15 fetuses with congenital nephrosis, distinct colloid‐filled cystic tubular dilations were seen scattered in the renal cortex. Similar structures were not present in the controls. It is suggested that these structures are pathognomonic of congenital nephrosis in the fetus and make diagnosis possible even without electron microscop

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1981.tb00188.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY