摘要:

Two cases of epidermoid carcinomain situof the portio/cervix and the endometrium of the uterine body of a 58‐year‐old and a 76‐year‐old woman are presented. The histology is described and the differentiation of the precancerous epithelium is discussed on the basis of the literature. The indifferent basal‐cell is suggested to be the cell of origin of physiological as well as pathological proliferations which to some extend may be influenced by the stroma

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1972.tb00261.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

A case of Crohn's disease of the colon coexisting with an alimentary, differentiated adenocarcinoma extending from cardia to the anus is reported. The criterions for the diagnosis morbus Crohn and the association between the two diseases are discussed.

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1972.tb00262.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

The morphological changes in 18 isografted and 108 allografted hearts have been studied in three inbred strains of rats. Focal cellular infiltrates were occasionally present in isografts in or near areas of infarction, and showed regressive tendency during the weeks after transplantation. Lymphoid cell infiltration in allografts was observed from the third day and increased progressively till a few days before terminal rejection, at which time extensive myocardial degeneration and oedema were the most prominent changes. Electrocardiograms from isografts remained almost unaltered for prolonged periods, while allografts gradually lost voltage of the R‐wave during rejection. Haemagglutinating red cell antibodies and lymphocytotoxic antibodies were regularly produced during rejection in the combinations investigate

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1972.tb00263.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

24 recently weaned Sprague‐Dawley rats were divided equally into 3 groups and given distilled drinking waterad libitumcontaining 0, 1 or 5 ppm F‐ (as NaF), respectively. Among the 13 animals that received the fluoridated water and survived the 2‐year experimental period, 4 developed macroradiographically demonstrable resorption cavities in their femurs. Three of these animals belonged to the 1 ppm group. No resorption cavities were seen in the 6 surviving, control rats. There was no sign of tooth changes, especially no striated depigmentation of the enamel of the inc

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1972.tb00264.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

Vesico‐venous anastomosis or urine‐infusion in rats resulted in a marked increase in renin substrate, which increase, however, on an average was less pronounced than that found in nephrectomized rats. These results do not allow an unambiguous answer to the question of the role of ceased urine excretion in the postnephrectomy increase in renin substrate in rats. Peritoneal dialysis did not affect renin substrate in normal rats, but increased it in uninephrectomized rats and in binephrectomized rats. The post‐binephrectomy increase in substrate was markedly more pronounced when both kidneys were removed simultaneously than when nephrectomy was performed in two

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1972.tb00265.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

While renin substrate is increased to values of about 2000–4000 ng 24 hours after simultaneous binephrectomy, the values obtained inpreviously uninephrectomizedorunilaterally ureter ligated ratsare only about 50 to 75 per cent as high (about 1000–2500 ng) 24 hours after removal of the remaining kidney. This decreased reaction is found as early as 30 minutes after uninephrectomy and is still found well over a month later. If the operations (binephrectomy or removal of remaining kidney) are preceded by 17 hourshypoxia, the values in rats whether binephrectomized in one step or in two steps are equally low (600–1700), while pretreatment withoestradiolin both groups results in about equally extremely high values (3500–6000). Previously uninephrectomizedrenal hypertensive ratsshow the same decreased response as normal rats if the untouched kidney is removed before the clipped, but if the clipped kidney is removed before the untouched, the values are as high as those found when both kidneys are removed at the same time. The effect of previous uninephrectomy seems neither related to the decrease in renal renin or to the retention of urinary constituents caused by the op

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1972.tb00266.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

Unilateral renal artery stenosis was produced in 60 rats. Hypertension developed in 46, and was allowed to persist for various lengths of time. Nine unoperated rats served as normal controls. The adrenergic innervation pattern of the kidneys was examined by the histochemical fluorescence method. In the stenosed kidney of the early hypertensive rat there was a reduction and disappearance of the nerve pattern, particularly at the juxtaglomerular level. Prolongation of the hypertension first led to normalization of the nerve pattern in the stenosed kidney, and later to the appearance of large numbers of intensely fluorescent nerve fibres in this kidney. The possibility that the innervation alterations are the result of a denervation of the stenosed kidney followed by a re‐innervation is discussed, but found less probable. It is alternatively suggested that the findings reflect a depletion of the adrenergic transmitter due to an angiotensin‐induced increase in the release of the substance during the developmental phase of the hypertension. The findings in the stenosed kidney of late hypertensive rats may either reflect an over‐loading by adrenergic transmitter or be a non‐specific feature secondary to the contraction of the kidney par

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1972.tb00267.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

A modification of Volet's filter imprint technique was applied to a number of cytological specimens. The imprint technique was compared with the original membrane filter technique with a view to cellular density, cell preservation and detail, as well as diagnostic accuracy. The result shows that the imprint method is quick, simple to perform, and in respect to diagnostic accuracy it is equal to or even superior to the standard membrane filter method. Lastly, as far as urinary specimens are concerned, both methods appear to give somewhat more accurate diagnostic results than the conventional centrifugation‐smearing technique, although this aspect was not thoroughly investigate

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1972.tb00268.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

Electron microscopic studies of the rat lung were carried out at various intervals after subcutaneous injection of paraquat. Within 12–18 hours after paraquat injection, capillary engorgement and interstitial oedema were noted in alveolar walls. After 24 hours there was, in addition, mitochondrial degeneration and cytoplasmatic vacuolization in granular pneumocytes, membraneous pneumocytes, and capillary endothelial cells. Desquamation of necrotic alveolar epithelial cells was a characteristic feature 48 hours after injection of paraquat. Many of these desquamated cells were identified as granular pneumocytes from their preserved lamellar inclusions. The severe ultrastructural lesions of the alveolar epithelium may serve to explain the derangement of pulmonary surfactant which has been observed in paraquat poisoning under similar experimental condition

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1972.tb00269.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY

摘要:

The chromosomes of 7 neurinomas and one neurosarcoma were studied. Three of the neurinomas had a normal, diploid stemline but the other four tumours had pseudodiploid‐hypodiploid stemlines. In the latter stemlines the chromosomal abnormalities were restricted to the groups B, C, E17–18 and G. The three, first mentioned chromosome groups also appeared to participate in the formation of markers, which were found in 3 of the 4 abnormal stemlines. The numerical and structural pattern in the neurinomas differed from that observed both in the meningomas and in the pituitary adenomas. The neurosarcoma had a hypertriploid mode, and the cells in the modal region usually had 12–14 markers. Due to the extensive chromosomal rearrangements in the sarcoma cells it was only possible to find a few karyological similarities between the neurosarcoma and the neuri

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1972.tb00270.x

出版商:Blackwell Publishing Ltd    

年代:1972

数据来源: WILEY