摘要:

With a view to investigating some of the causes why the size of liver cell nuclei increase in virus hepatitis, the nuclear size and the nuclear contents of DNA, nucleic acid and protein were measured by cytophotometry. The liver cell nuclei could be grouped in classes according to their contents of DNA, nucleic acid, and protein and, as in control livers, diploid nuclei were always most frequent. Nuclei with intermediate DNA values, probably S‐phase nuclei, were more frequent in hepatitis livers than in controls. The average size of nuclei from patients with hepatitis was significantly larger than that from controls, whereas the DNA content was the same. A significant, positive correlation between nucleic acid content, protein content and nuclear area was found. The high correlation between nuclear protein content and nuclear size simultaneously with the increased nuclear size during hepatitis is assumed to reflect an increased nuclear functio

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1976.tb00103.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

In 32 experiments involving transplantation of human malignant melanomas to the mouse mutant nude, tumourtake was observed in 14 instances. The tumour tissue which took and grew after inoculation was derived from malignant melanoma metastases of the skin (10 takes from 13 transplantations), and from primary malignant melanomas of the eye (4 takes from 6 transplantations). Not one of 13 attempts to transplant primary tumours of the skin was successful. In 7 instances serial transfers of transplanted tumour were successful, the degree of success ranging from 3 to 41 passages. Some passages were wilfully interrupted but two are continuing. The transplanted tumours grow locally. Neither lymph node metastases nor organ metastases have been observed. Histological appearances of the transplanted tumours, also after serial passages, were identical with those of the original human donor material. The human tumour/nude mouse system is contrasted and compared with other heterotransplantation models.

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1976.tb00104.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

Ethylene‐1‐hydroxy‐1, 1‐diphosphonate (EHDP) was administered intraperitoneally to one‐day old rats at a concentration of 30 and 40 mg/kg body weight/injection. Two groups of animals received four doses, respectively, over a 44‐hour‐period and a third group received two high doses with a 15‐hour interval, the total amounts corresponding to 30, 40 and 20 mg/P/kg body weight. Animals in the first two experimental groups showed increased width of the hypertrophic zone as compared with normal controls and lack of calcified septa within the zone of provisional calcification. In the calcification zone, persistent atypical chondrocytes were present and in the septa a large number of matrix vesicles which hardly ever contained any crystals. The ground substance of these septa contained fine precipitates, probably representing proteoglycan complexes which were not seen normally in this zone. In the third group, the septa of the calcification zone were calcified and the hypertrophic zone was not clearly widened. In the metaphysis, remnants of cartilage or osteoid were observed as “islands” covered with osteoblast‐like cells which showed signs both of collagen and apatite formation, the latter evidenced by the appearance of crystals within the matrix vesicles. It is suggested that the complex effects observed in calcifying cartilage after administration of high doses of EHDPin vivoare not restricted solely to the stage

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1976.tb00105.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

In slices of non‐pregnant rabbit uterus, renin was gradually inactivated during incubationin vitroat 37°C., for 44 hours. The percentual rate of inactivation (40 per cent/44 hours) was, however, only about half of that found in uterine slices from pregnant and post‐partum animals despite the fact that the endogenous renin concentration was much lower in the non‐pregnant uteri. In control experiments with kidneys with the same high renin content as in the pregnant uteri only about 30 per cent of the renin was inactivated in 44

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1976.tb00106.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

The histochemical enzyme pattern in normal, extra‐hepatic bile ducts from rabbits was studied. A difference between the duct epithelium and the crypt epithelium was noted mainly in the activity of gamma‐glutamyl‐transpeptidase and alkaline phosphatase which only stained positively in the crypts. No difference from the normal enzyme pattern was noted after diversion of the bile flow for up to 30

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1976.tb00107.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

Rats were injected with paraquat, 35 mg/kg, and killed 8 or 12 hours later. Electron microscopic studies of the lungs revealed degenerative changes in alveolar epithelium and alveolar capillary endothelium after 8 hours. After 12 hours, the alveolar lining layer was contaminated with cellular debris from disintegrating alveolar epithelium. This contamination is probably responsible for the inactivation of lung surfactant that can be demonstrated in early stages of experimental paraquat poisoning.

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1976.tb00108.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

Generalized lipodystrophy (Berardinelli‐Seip's syndrome) was diagnosed in a boy at the age of 81/2 months. Ten months later he died because of aspiration of food. Necropsy with special reference to the CNS revealed hypothalamic lesions, probably of a malformative or hamartomatous nature. The findings lend additional support to the view that hypothalamic dysfunction is responsible for the signs and symptoms of generalized lipodystroph

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1976.tb00109.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

Biopsies from the temporal arteries of 62 out of 80 patients presenting the clinical picture of temporal arteritis and/or polymyalgia rheumatica showed morphologically active or healed arteritis. Fifty‐five of these biopsies revealed anti‐IgG activity as measured by the mixed agglutination test. In 21 of the 27 cases which could be completely studied, the anti‐IgG activity was connected with the presence of IgA, either alone, or together with IgG or IgM, or both, and complement. All of these 21 biopsies showed morphologically active granulomatous arteritis with signs of tissue destruction. In 6 biopsies, the active component appeared to be some type of Fc receptor in the tissue. Morphologically these biopsies showed either nongranulomatous mononuclear arteritis without definite necrosis or they represented various stages of healing arteritis with no or minor signs of tissue destruction. Weak anti‐IgG activity was often found in a morphological type characterized by minimal inflammatory activity. These lesions are easily overlooked and the mixed agglutination test proved to be a good diagnostic tool in such cases. Arteries without anti‐IgG activity showed no signs of active

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1976.tb00110.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

Numerous papers have emphasized the damaging effect of salicylic acid compounds on the stomach mucosa. The investigations here reported aimed at examining the effect on gastric and duodenal morphology of a moderate dose of aspirin. Oxidative enzymes were evaluated histochemically. To rats in groups of 16, aspirin tablets, placebo tablets, or the same with additional 1 cc of 0.1 N HCl, were administered twice a day for 6 weeks. Approximately 160 mg/kg/24 hrs. were ingested. Microscopy revealed severe hyperaemia along with focal gastritis in the aspirin treated animals. Chronic gactric ulcers were observed in 18 rats in the aspirin treated groups, particularly in the group where HCl was added. Ulcerations in the area of the pyloricgland occurred in the latter group only. A reduction in mucopolysaccharides was demonstrated and involved the acid as well as the neutral ones. NADH‐reductase and cytochrome oxidase were inhibited not only in the surface cells but also in those in the deeper layers. The reduction in oxidative enzymes in otherwise undamaged areas suggests an interference with the cellular metabolism, probably processes in the respiratory chain which might lead to reduction in energy‐rich phosphate bo

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1976.tb00111.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

The first case of central pontine myelinolysis in Scandinavia is presented. A premortem diagnosis was established on the basis of the history of chronic alcoholism, the picture of severe electrolyte disturbance and the development of the neurological syndrome. The postmortem findings verified the clinical diagnosis. A possible aetiological mechanism is postulated. The cause is believed to be a damage to the energy dependent electrolyte transport across the cell membrane, resulting in a cytotoxic oedema and death of the oligodendroglial cells of the brainstem which are particularly vulnerable.

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1976.tb00112.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY