摘要:

Fourteen epithelial thymomas and eight granulomatous thymomas were studied in order to clarify the clinicopathological relationship of these diseases. The age distribution, histological picture and clinical course of granulomatous thymoma were quite different from those of epithelial thymoma but similar to those of the nodular sclerosing type of Hodgkin's disease. Granulomatous thymoma should therefore be distinguished from epithelial thymoma and perhaps called Hodgkin's disease of the thymus.

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1973.tb00469.x

出版商:Blackwell Publishing Ltd    

年代:1973

数据来源: WILEY

摘要:

A standardized silver impregnation method coupled with Alcian blue staining is described. The method purports to differentiate between acid carbohydrates, reticulin fibres and collagen fibres. It is suggested that the method could be used in the study of transition zones between reticulum fibres and collagen fibres.

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1973.tb00470.x

出版商:Blackwell Publishing Ltd    

年代:1973

数据来源: WILEY

摘要:

A description of artefactual staining in 156 needle biopsies of the liver is given. The following representative methods were employed: Alcian blue'basic fuchsin mixture pH 3, fast green FCF pH 8, azure A'eosin Y mixture pH 5, gallocyanin'chromalum, Feulgen procedure and aluminium'haematein. Changes in stainability were seen in the 3–15 most peripheral cell layers and affected both cell nuclei and cytoplasm as well as sinusoidal lining. A dissociation of nucleoprotein and denaturation of protein in the outermost layers of the biopsy effected by the needle is suggested as being the cause of the altered stain‐ability. The consequences of these findings for the evaluation of needle biopsies is discus

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1973.tb00471.x

出版商:Blackwell Publishing Ltd    

年代:1973

数据来源: WILEY

摘要:

It is well known that the pre‐operative treatment of thyrotoxic patients influences the histology of surgical specimens. However, a description of the exact relationship between the type of pre‐operative treatment and the histology is not available. The aim of the present investigation was to obtain some information on this point. It was found that the histology of thyrotoxic glands varied considerably and that the “classical” picture was seen only in about one third of the cases. Thyroids from patients treated only with iodine showed more variation within the specimen, taller cells, larger nuclei and nucleoli, more marginal vacuolization, and more germinal centres, but less vascularization of the stroma than thyroids from patients treated with sulphur‐containing thy

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1973.tb00472.x

出版商:Blackwell Publishing Ltd    

年代:1973

数据来源: WILEY

摘要:

The course of alloxan diabetes during 19 months was studied in 62 duct‐ligated and 26 sham‐operated female rats. Nine additional rats were used as buffer‐injected sham‐ operated controls. Alloxan was administered 5–6 weeks after duct ligation. The mortality among the alloxan‐treated rats was high and many animals died during ether anaesthesia a t glucose tolerance tests or from late sequelae of alloxan‐induced kidney lesions. In duct‐ligated rats, both the hypoglycaemic phase 4–8 hours after alloxan administration and the subsequent hyperglycaernia during the first 4 days were distinctly marked. After these days during which signs of instability were observed, the fasting blood glucose level in the duct‐ligated rats returned within the normal range after 5 months a t which stage the only 3 surviving sham‐operated controls still were hyperglycaemic. The latter showed, how‐ ever, varying degrees of alloxan‐induced kidney lesions. The pancreas was studied by light microscopy in 29 duct‐ligated and in the 3 surviving sham‐operated alloxan‐diabetic rats. From the first week and onwards, signs of regenerative phenomena of the islet tissue, consisting of large, clear, sparsely granulated cells of the so‐called “agranular” type, were observed in the islets of the alloxan‐treated animals. Furthermore, some evidence was ob‐ tained that the large, sparsely granulated cells had the ability to differentiate into β‐cells. Despite this normalization of the fasting blood glucose level of the alloxan‐diabetic duct‐ligated rats and despite these morphological signs of β‐cell regeneration, no alloxan‐ treated animals showed a complete recovery from their diabetes, as glucose tolerance tests, performed 8 months after alloxan administration, were still of diabetic type. However, histological examination of the pancreas in 2 rats 19 months after alloxan administration were by light microscopy found to present mainly normal islet cells in both the atrophied and the intact parts of the pare

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1973.tb00473.x

出版商:Blackwell Publishing Ltd    

年代:1973

数据来源: WILEY

摘要:

In 3 renal transplanted patients perirenal fibrosis developed within one year after transplantation. The kidney function slowly decreased and uremia and hypertension developed in spite of intensive immunosuppressive treatment. The characteristic morphological changes in kidneys with perirenal fibrosis were atrophy and fibrosis localized in the superficial cortex. At biopsy this condition could easily be separated from immunologic and infective lesions of the parenchyma, as well as from vascular complications causing decrease in kidney function and hypertension. The clinical histories indicate that the perirenal fibrosis was caused by complicating perinefritis and/or perirenal hemorrhage in all three cases. In rats a closely similar lesion could be experimentally produced. It is concluded that perirenal fibrosis should be considered as an alternative diagnosis to chronic rejection and vascular complications in transplanted patients with late graft failure and hypertension.

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1973.tb00474.x

出版商:Blackwell Publishing Ltd    

年代:1973

数据来源: WILEY

摘要:

The course of alloxan diabetes was studied ultrastructurally during 19 months in duct‐ligated and control rats. During the first days after alloxan administration, selective degeneration was observed in most β‐cells of both atrophic and intact pancreatic parenchyma. New formation of islet cells was found from about one week. Two different kinds of cells without characteristic granulation were seen: those which seemed to be precursor cells to granulated islet cells, and those which appeared to represent hypertrophic, de‐granulated β‐cells. The number of α2‐cells was increased during the first months after the injection of alloxan. At 19 months a normal fine structure was found i

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1973.tb00475.x

出版商:Blackwell Publishing Ltd    

年代:1973

数据来源: WILEY

摘要:

The occurrence of reticulum cell neoplasms in normal and benzene treated hairless mice (hr/hr) was investigated. 39 per cent of a group of untreated mice had these neoplasms at a mean age of about 20 months. The same tumour yield was also found in another group of mice which were painted twice weekly on the back skin with benzene up to a mean age of 20 months. The histological patterns of reticulum cell neoplasms characteristic of these mice are described.

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1973.tb00476.x

出版商:Blackwell Publishing Ltd    

年代:1973

数据来源: WILEY

摘要:

In bronchial epithelium of human foetuses, cells containing fluorogenic amine were observed to take up amine precursors and to synthesize and store further amounts of amine. Other cells apparently devoid of a cellular store of amine were capable of taking up amine precursors. The possibility of distinguishing two cell types is discussed. In human adults, no aminecontaining cells were observed in the epithelium of the main bronchi. However, a few cells with a specific fluorescence were obtained after treatment with the precursor amino acid L‐DOP

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1973.tb00477.x

出版商:Blackwell Publishing Ltd    

年代:1973

数据来源: WILEY

摘要:

Biopsy specimens from 20 leprosy patients have been studied. Adjacent sections were in each case both stained by the ordinary Ziehl‐Neelsen method and after oxidation with periodic acid (Nyka's method). Sections from tuberculoid, indeterminate and lepromatous lesions all revealed an increased number of acid fast bacilli after oxidation. In ten examinations of tuberculoid and indeterminate cases the increase observed was in average four‐fold. It is concluded that there is a considerable higher number of bacilli present in leprous tissue than revealed by the ordinary Ziehl‐Neelsen m

ISSN:0365-4184    

DOI:10.1111/j.1699-0463.1973.tb00478.x

出版商:Blackwell Publishing Ltd    

年代:1973

数据来源: WILEY