ISSN:0732-9482    

DOI:10.1089/cdd.1985.2.1

年代:1985

数据来源: MAL

摘要:

Polyclonal 131I rabbit antirat ferritin localizes in certain hepatoma models. The effect of intraperitoneal iron dextran on tumor and sera ferritin content and tumor and normal tissue localization with 131 I antiferritin was studied. Separate groups of 10-12 animals were injected with escalating doses of 131I-antiferritin 1gG, or nonspecific IgG, one week after injection with iron dextran or normal saline. The results demonstrate that tumor, serum, and normal tissue ferritin content was increased after iron dextran administration but tumor localization increased after administration of 131I-antiferritin in the H4II-E and 7800 models. The 3924A and 7777 models showed no tumor localization with or without iron dextran but did show an increase in normal tissue localization after iron dextran. Immunoperoxidase staining of tissues with anti-ferritin revealed increased staining in the liver and spleen and only a slight increase in the tumors after iron dextran was administered. The results demonstrate that tumor localization is a complex phenomenum that depends on normal tissue, sera, and tumor-antigen distribution

ISSN:0732-9482    

DOI:10.1089/cdd.1985.2.3

年代:1985

数据来源: MAL

摘要:

Both cytotoxicity and host toxicity were examined for the alkylating agents HN2, BCNU and L-PAM administered intravenously (IV) either as a single bolus injection or a 24-hour infusion. The bolus injection was more effective than the infusion schedule at a given dose for BCNU and L-PAM. Unexpectedly, the HN2 infusion schedule was more effective than bolus injection at a given dose. When host survival was the endpoint, both HN2 and L-PAM were shown to be more effective by the infusion schedule.

ISSN:0732-9482    

DOI:10.1089/cdd.1985.2.11

年代:1985

数据来源: MAL

摘要:

Previously reported analyses of autopsy data gathered from patients dying from the sequelae of adenocarcinomas of the upper rectum revealed a step-wise sequence in the development of distant metastases. First, dissemination via the portal vein led to secondary hepatic metastases. Cancer cells from these liver metastases (not the primary cancer) disseminated via the inferior vena cava to generate tertiary pulmonary metastases. Cancer cells from the lung metastases (not the primary or secondary cancers) then disseminated via the arterial route to give rise to metastases in other organs.We propose a protocol for the treatment of patients with upper rectal carcinomas, based on the expectation that, at different times after diagnosis, some patients will have no distant metastases, metastases in the liver only, or in the liver and lungs only. The protocol for therapy is based on currently available liposome technology, by means of which high doses of drugs can be targeted to the liver and lungs containing the metastases, yet distinct from the metastases. It is argued that selective local delivery of this type would increase the dose of cytotoxic agent delivered, thereby increasing the chances of overcoming the relative drug-resistance of the metastatic cancer cells and, at the same time, reduce the risk of nonspecific toxicity.Liver and lung-selective liposomes could, when necessary, be delivered at the same time, in the same systemic venous infusion.

ISSN:0732-9482    

DOI:10.1089/cdd.1985.2.19

年代:1985

数据来源: MAL

摘要:

Two patients with osseous malignant lesions were treated with the tourniquet infusion method. The first patient, with two metastatic lesions in the left femur resulting from a renal adenocarcinoma, had three courses of intra-arterial Adriamycin. Biopsies of these lesions showed that the distal lesion, which was perfused during each treatment, was histologically negative, whereas the proximal lesion, which was not perfused because of the position of the catheter, contained the viable tumor.The second patient, a 12-year-old girl with osteogenic sarcoma of the proximal portion of the right tibia, had three courses of intra-arterial chemotherapy with Adriamycin and cisplatinum, and then underwent open biopsy, which was histologically negative. Another open biopsy six months later was also histologically negative. She has normal use of her extremity and, at eleven months since the initiation of treatment, she remains disease free. The evaluation of the tourniquet infusion technique in greater numbers of patients with bone tumors under carefully controlled conditions, appears warranted.

ISSN:0732-9482    

DOI:10.1089/cdd.1985.2.35

年代:1985

数据来源: MAL

摘要:

Cisplatin (10 mg in 50 ml normal saline) was administered daily for five days directly into the pericardial cavity of a patient with metastatic nonsmall cell lung cancer and a malignant pericardial effusion. No systemic or local side effects were observed. A dramatic decrease in reaccumulation of pericardial fluid was noted which persisted until the patient's death four months later. On the basis of this experience, further investigation of the intrapericardial administration of cisplatin as treatment to control malignant pericardial effusions appears warrented.

ISSN:0732-9482    

DOI:10.1089/cdd.1985.2.49

年代:1985

数据来源: MAL

摘要:

The efficacy of Human6IFN (HLIFN) given in a pulse fashion was determined in a phase II study. Ninety-one cancer patients were evaluated (9 myeloma, 12 breast, 14 prostate, 9 melanoma, 4 renal, 6 astrocytoma, 7 ovarian, 9 large bowel, 7 gastric, 14 head and neck). They all had advanced progressive cancer that was resistant to chemotherapy and/or radiotherapy. Patients were treated by intramuscular injection of 6 × 102I.U./m2 for three consecutive days every four weeks. 84 patients were evaluable. Complete clinical response was obtained in 23 patients (4 myeloma, 2 breast, 5 prostate, 1 melanoma, 1 renal, 2 astrocytoma, 2 ovarian, 2 large bowel, 1 gastric, 3 head and neck).Partial responses were observed in 35 patients (3 myeloma, 7 breast, 6 prostate, 4 melanoma, 1 renal, 2 astrocytoma, 3 ovarian, 4 head and neck). Objective responses were related (P<0.01) to serum IFN level, with complete and partial responses (P<0.01) more commonly seen in those patients whose serum IFN levels at two hours were in the range of 1000 to 1650 I.U./ml. Side effects resulting from pulse IFN were acceptable for this group of patients and consisted of fever, transient chills, malaise and asthenia, and transient thrombocytopenia and leukocytopenia. The extent of fever was directly related (P<0.01) to response, and was most elevated in patients who achieved objective responses. IFN administered in a pulse fashion appears to be more effective than daily IFN and merits further evaluation

ISSN:0732-9482    

DOI:10.1089/cdd.1985.2.53

年代:1985

数据来源: MAL

摘要:

Clinical toxicities and pharmacokinetics of methotrexate (MTX), associated with reduced citrovorum factor (CF) neutralization, were studied on 279 infusions in 25 children with various malignancies. MTX, at 1000 - 8400 mg/m2, was infused during six to 24 hours with multiple schedules of reduced CF rescue. Plasma MTX levels ranged from 7.0 x 10-5to 7.0 x 10-4M during MTX infusion. The levels declined rapidly with a two-phase elimination pattern (t½ = 1.2-2.5 hours, t½ = 18-32 hours). The folate level in the plasma ranged from 5 x 10-7M to 1.4 x 10-6M when CF was administered every six hours or every three hours, respectively. Limited bone marrow suppression was seen in only seven percent of infusions, with moderate elevation of GOT and GPT in 20% of infusions, and stomatitis in only 2.6% of infusions, despite reduction in the total dose of CF from 225 mg to 105 mg and despite delaying CF initiation from nine hours to thirty-six hours after the start of MTX infusio

ISSN:0732-9482    

DOI:10.1089/cdd.1985.2.77

年代:1985

数据来源: MAL