ISSN:1072-4109    

出版商:OVID    

年代:2000

数据来源: OVID

摘要:

Summary:Pathologists seeking clinicopathologic definition of papillary squamous cell carcinoma may, at times, feel as if they have been given a pathologic salmagundi to digest. Why the definition of the carcinoma is so elusive is unclear. Perhaps one way to address the problem is to relate what the papillary squamous cell carcinoma is not. It is not the verrucous carcinoma nor is it the exophytic, conventional squamous cell carcinoma, which is usually broad‐based, well‐to‐moderately differentiated, most often keratinizing, and with an easily defined invasive (endophytic) component. To date, however, the few reports dealing with papillary squamous cell carcinoma have muddied diagnostic waters by definitely not excluding these other forms of squamous cell carcinoma.Three different perceptions of papillary squamous cell carcinoma of the upper aerodigestive tract are presented in the commentary. Not only are the descriptions and depictions of the cytomorphology different among the three, so too are the biologic courses and responses to therapy. We believe the papillary squamous cell carcinoma is a separable and definable clinicopathologic entity. The reader is left to choose.

ISSN:1072-4109    

出版商:OVID    

年代:2000

数据来源: OVID

摘要:

Summary:There are at present very few well‐characterized molecular alterations that occur at high frequency in prostate cancer. Recent evidence suggests that alterations in the pp32 family of nuclear phosphoproteins may be a common event in prostate cancer. Individual members of this gene family appear to function as either tumor suppressors or oncogenes.

ISSN:1072-4109    

出版商:OVID    

年代:2000

数据来源: OVID

摘要:

Summary:One of the challenging areas in genitourinary pathology is the recognition of early invasion in urothelial neoplasia. Not uncommon, the patterns of invasion into lamina propria are subtle because a desmoplastic response is absent. Tangential sectioning due to inability to orient transurethral resection of bladder tumor specimens, crush and cautery artifacts further compound this problem. This review is presented to familiarize surgical pathologists with the criteria and different patterns of lamina propria invasion by urothelial carcinoma. Problems and pitfalls associated with the recognition of invasion and the clinicopathologic significance of lamina propria invasive urothelial cancer are also discussed.

ISSN:1072-4109    

出版商:OVID    

年代:2000

数据来源: OVID

摘要:

Summary:Recently, there have been a number of new devices introduced for stereotactic biopsy of nonpalpable, mammographically detected lesions. The vacuumassisted core biopsy (VACB) (Minimal Invasive Breast Biopsy (MIBB), U.S. Surgical, Norwalk, CT; Mammotome, Biopsys Medical, Cincinnati, OH) obtains multiple tissue cores (11‐gauge) in a circumferential manner around the biopsy probe, inserted under stereotactic guidance. It provides more complete sampling of mammographic lesions than the conventional 14‐gauge stereotactic core biopsy, reducing the number of unsatisfactory biopsies. The advanced breast biopsy instrumentation (ABBI) (United States Surgical Corporation, Norwalk, CT) system utilizes stereotactic technique and an oscillating blade‐cutting mechanism to obtain a single large diameter (5mm to 20mm) tissue core, with the aim of obtaining an intact lesion in its entirety for histologic assessment. Its potential as a treatment option is still under investigation. Suggested protocols for specimen handling are presented together with a review of the recent literature. Close liaison with radiologists and surgeons performing these biopsies will allow the collection of further outcome data to evaluate the strengths and weaknesses of each technique.

ISSN:1072-4109    

出版商:OVID    

年代:2000

数据来源: OVID

摘要:

Summary:Nasopharyngeal angiofibromas (NA) are rare tumor‐like lesions characterized by architecturally irregular vessels set in a fibrous stroma. The unique morphology, the strong predilection for male adolescents, and the uncertainty about its etiology contributes to significant confusion regarding the classification of NA, which still has not been solved today. Based on immunohistochemical and electron microscopic examinations, we demonstrate in detail the various unusual vascular architectural features of NA. They represent discontinuous vascular basal laminae, focal lack of pericytes, and pronounced irregularity of the smooth muscle layers. In thick smooth muscle layers and pads, the orientation of muscle cells is frequently disturbed, and the individual cells differ in size and shape. Occasionally, the muscle layers disperse peripherally into individual cells, creating the impression of vessel‐independent smooth muscle cells within the stroma. The summation of all morphological irregularities demonstrated in this paper allows the conclusion that NA represent vascular malformations.

ISSN:1072-4109    

出版商:OVID    

年代:2000

数据来源: OVID

摘要:

Summary:In this review article the benign tumors and tumor‐like lesions of the adult kidney are discussed. The incidence of benign renal tumors is low, especially when compared to renal cell carcinomas, as most are detected incidentally or at autopsy. Some of these tumors, as their names imply, are unique to the kidney, e.g., renal adenoma, metanephric adenoma, renal oncocytoma, nephrogenic adenofibroma, mesoblastic nephroma, capsuloma, juxtaglomerular cell tumor, renomedullary interstitial cell tumor (medullary fibroma), cystic nephroma, cystic partially differentiated nephroblastoma, and cystic hamartoma of the renal pelvis, while others, such as angiomyolipoma, leiomyoma, hemangioma, lipoma, etc., are not unique to the kidney and show similar morphologic features in the other sites they affect. Of the tumor‐like lesions, xanthogranulomatous pyelonephritis, malakoplakia, and renal cysts are the most common. The other entities, such as fibroepithelial polyp, are rare, most having been the topic of case reports. In Part I of this paper the benign epithelial tumors of the kidney were previously discussed. This paper (Part II) is devoted to the benign mesenchymal tumors, mixed mesenchymal and epithelial tumors, and the tumor‐like lesions.

ISSN:1072-4109    

出版商:OVID    

年代:2000

数据来源: OVID

ISSN:1072-4109    

出版商:OVID    

年代:2000

数据来源: OVID