摘要:

Summary:The spectrum of renal neoplasms has expanded in recent years. Although most of the work taking place in this field has concerned malignant neoplasms of the kidney, there have been significant improvements in our knowledge of benign renal tumors and tumor-like lesions, especially in renal cell adenoma, renal oncocytoma, and renal angiomyolipoma. Awareness and knowledge of these benign lesions is important because they are often included in the differential diagnoses of malignant tumors, with which they may be confused both clinically and pathologically. The authors review the topic of benign renal neoplasms and tumor-like lesions that occur in adults, emphasizing some of the newly described aspects of these lesions.

ISSN:1072-4109    

出版商:OVID    

年代:1999

数据来源: OVID

摘要:

Summary:Melan-A/MART-1 is a recently identified new melanocytic differentiation marker, which is recognized as an antigen on melanoma cells by cytotoxic Tlymphocytes. It is of interest for clinicians as potential immunotherapeutic target and it is relevant for pathologists as a novel diagnostic marker, since two antibodies (A 103 and M2-7C10) have become available to study Melan-A/MART-1 expression on archival material. Both antibodies are useful in the differential diagnosis of melanocytic tumors, especially metastatic tumors, since they are more sensitive than HMB-45. Both antibodies are also of diagnostic value in the recognition of perivascular epithelioid cell tumors (angiomyolipoma, lymphangioleiomyomatosis, and clear cell tumor). Since A103 has the unique property of staining many steroid hormone producing cells, this antibody is also of value for the recognition of tumors derived from these cells, such as adrenocortical carcinomas. Both antibodies are likely to be included in the routine diagnostic armamentarium of many immunohistochemical laboratories in the near future.

ISSN:1072-4109    

出版商:OVID    

年代:1999

数据来源: OVID

摘要:

Summary:This commentary addresses the nature of interstitial cells of Cajal (which can now be conveniently demonstrated by immunostaining for c-kit) and their possible role in the genesis of various motility disorders of the gastrointestinal tract. The evolution of the concept on the nature of gastrointestinal stromal tumors is discussed, with emphasis on the recent finding of a very high frequency of c-kit immunoreactivity in these tumors, suggesting that they might exhibit differentiation toward interstitial cells of Cajal. The practical immunohistochemical applications of antibodies to c-kit in diagnostic pathology are also discussed.

ISSN:1072-4109    

出版商:OVID    

年代:1999

数据来源: OVID

摘要:

Summary:This commentary summarizes the clinicopathologic features of the reported and personally observed cases of benign mesothelial cells in lymph node. This condition occurs most commonly in the setting of chronic effusion, serosal inflammation, or reaction to adjacent lymphoma. The differential diagnosis from metastatic mesothelioma is discussed.

ISSN:1072-4109    

出版商:OVID    

年代:1999

数据来源: OVID

摘要:

Summary:This commentary discusses the variety of nonneoplastic proliferations, putative preneoplastic lesions, and benign neoplasms of type 2 pneumocytes; the nature and differential diagnosis of micronodular pneumocyte hyperplasia; and the pulmonary manifestations of tuberous sclerosis complex.

ISSN:1072-4109    

出版商:OVID    

年代:1999

数据来源: OVID

ISSN:1072-4109    

出版商:OVID    

年代:1999

数据来源: OVID

ISSN:1072-4109    

出版商:OVID    

年代:1999

数据来源: OVID

ISSN:1072-4109    

出版商:OVID    

年代:1999

数据来源: OVID

ISSN:1072-4109    

出版商:OVID    

年代:1999

数据来源: OVID

ISSN:1072-4109    

出版商:OVID    

年代:1999

数据来源: OVID