ISSN:0022-4790    

DOI:10.1002/jso.2930580102

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1995

数据来源: WILEY

摘要:

AbstractA retrospective study was conducted of 993 malignant tumors of the lung in 977 patients. The male‐female sex ratio was 2.6:1. The age distribution of the males did not differ from that of the females and the overall mean age was 64.3 ± 9.5 years (range, 13–85 years). Forty‐three percent of the patients were in their seventh decade. The location was peripheral in 81% of the tumors and central in 19%. Of the central tumors, 85% were squamous cell (epidermoid) carcinoma (SCC), while 58% of the peripheral tumors were adenocarcinoma (ADENO). In males, 49% of all tumors were SCC and 36% ADENO, while in females 76% were ADENO. The incidence of positive lymph node metastasis increased in parallel with the pT status in both central and peripheral carcinomas. However, it was noted that, of peripheral lung carcinomas, no SCC with a diameter of 15 mm or less had lymph node metastasis, whereas 18.9% of the ADENO of this size were positive for lymph node metastasis. These results indicate that lymph node metastasis can occur even in small‐sized peripheral ADENO less than 15 mm. Thus, early detection and surgery together with mediastinal lymph node dissection are necessary even for small‐sized tumors to improve the prognosis in patients with peripheral ADENO of the lung. © 1995 Wile

ISSN:0022-4790    

DOI:10.1002/jso.2930580103

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1995

数据来源: WILEY

摘要:

AbstractTwenty‐three patients with liver metastases from soft tissue sarcoma were reviewed.Patients with metastases to the liver first had poorer survival than those who developed spread to other sites first (P=.0035). The median time from diagnosis of the primary tumor to diagnosis of liver metastases was 14 months; the median time from diagnosis of liver metastases to death was 7 months. The median survival from diagnosis for four patients who underwent liver resection was 54 months compared to 20 months for those who did not undergo resection (NS).Soft tissue sarcomas rarely metastasize to the liver; when this occurs it is usually late in the course of the disease and after it has spread to other sites. The opportunity for successful liver resection is infrequent but may prolong survival. © 1995 Wiley‐Liss,

ISSN:0022-4790    

DOI:10.1002/jso.2930580104

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1995

数据来源: WILEY

摘要:

AbstractA human signet ring gastric carcinoma cell line TSGH9201 was established in vitro. The cells grew in vitro as a monolayer with polygonal morphology and had a population doubling time of 34 hours. The cells secreted tumor markers CEA and CA 125. They were, however, not tumorigenic in athymic nude mice. Karyotypic analysis demonstrated a near tetraploidy with a modal chromosome number of 98. Northern blotting and immunocytochemical analysis revealed the expression of both transforming growth factor α and high levels of epidermal growth factor receptor. Cell growth was inhibited by the epidermal growth factor in vitro. The cell line may be a useful tool to study autocrine growth regulation through the epidermal growth factor receptor. © 1995 Wiley‐Liss,

ISSN:0022-4790    

DOI:10.1002/jso.2930580105

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1995

数据来源: WILEY

摘要:

AbstractImmunoproliferative small intestinal disease (IPSID), most common in Mediterranean countries, is characterized by lymphomatous infiltration of the small intestine and is usually associated with the synthesis of anomalous immunoglobulin alpha heavy chains. Flow cytometric analysis of DNA content, S phase fraction, and quantitative analysis of the proliferation‐associated nuclear antigen, P105, were performed in 23 patients with IPSID to determine if they could be used as prognostic indicators in this disease. Eighteen patients had low‐grade, two had intermediate‐grade, and three had high‐grade lymphoma. Eight patients had clinical stage IE disease, 12 had stage IIE, and three had stage IIIE disease. Eleven patients survived>5 yr (good prognosis), four survived between 2–5 yr (intermediate prognosis), and eight survived 2 yr or less (poor prognosis). The S phase fraction of patients with poor prognosis was significantly higher than those with intermediate or good prognosis (P<0.004). Flow cytometric evaluation of S phase fraction may offer important prognostic information in patients with IPSID and could be useful in the clinical management of patients with this highly variable clinical syndrome. Further studies evaluating the value of DNA flow cytometry in larger groups of patients with IPSID are warranted. © 1995 Wiley

ISSN:0022-4790    

DOI:10.1002/jso.2930580106

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1995

数据来源: WILEY

摘要:

AbstractThe aim of our study was to evaluate the clinical efficacy of preoperative injection of activated carbon in delineation of cancer location in laparoscopic colectomy. Activated carbon particles were injected during endoscopy into the normal colonic wall surrounding cancer lesions in five cases of early colon cancer, prior to laparoscopic surgery. The carbon‐stained area was clearly recognizable as a blackened patch on the serosal surface of the colon. Using the carbon‐stained area as a reference point, partial colectomies were successfully performed on all five patients. The preoperative injection of activated carbon assisted in the intraoperative delineation of early colonic cancer lesions. This method is recommended for the rapid and accurate delineation of early colonic cancers in laparoscopic surgery. © 1995 Wiley‐Lis

ISSN:0022-4790    

DOI:10.1002/jso.2930580107

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1995

数据来源: WILEY

摘要:

AbstractSurgeons in Poland are very skeptical about the positive role of adjuvant irradiation in patients with gastric cancer. A retrospective study of 21 patients with operable gastric cancer referred for irradiation to Cancer Centre in Warsaw between December 1984 and December 1991 was performed. Patients were qualified to receive adjuvant treatment because of bad prognostic factors—nonradical surgery (10 patients), infiltration of entire thickness of gastric wall (13 patients), and metastases in regional lymph nodes (9 patients). All patients were in good condition.They were treated by either telecobalt 60 unit or linear accelerator using 9–15 MeV photons. The total dose to the gastric bed and lymphatic was 46–50 Gy in 25 to 28 fractions, 5 days a week. The tolerance of treatment was good. None of these patients received 5‐FU either during irradiation or as maintenance therapy.We have obtained more than 50% overall survival rate at 3 years. Median survival was 27 months and median recurrent‐free interval 27 months. Local recurrence was found in four patients, distant metastases in five patients. In the group of 10 patients with nonradical surgery, 5 are alive without evidence of disease from 2 up to 7 years after treatment.Our preliminary results and good tolerance of treatment seem to support the beneficial role of adjuvant radiotherapy after gastrectomy in patients with risk factors of locoregional cancer recurrence. © 1995 Wiley

ISSN:0022-4790    

DOI:10.1002/jso.2930580108

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1995

数据来源: WILEY

摘要:

AbstractPlatelet‐derived growth factor (PDGF) in the resected pulmonary adenocarcinoma tissue of 88 patients was detected immunohistochemically by the avidin‐biotin‐peroxidase technique to determine whether or not it is a prognostic parameter. The 88 patients were divided into PDGF (‐) and PDGF (+) groups according to the stainability of the factor. The PDGF (‐) group included 39 patients and the PDGF (+) group 49. The 5‐year survival rate was 53% for the PDGF (‐) group and 17% for the PDGF (+) group (P<0.01). These findings indicate that the stainability of PDGF can be a prognostic parameter for pulmonary adenocarcinoma. © 1995 W

ISSN:0022-4790    

DOI:10.1002/jso.2930580109

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1995

数据来源: WILEY

摘要:

AbstractLymphokine‐activated killer (LAK) cells generated by culture of regional lymph node cells (LNC) with interleukin 2 (IL 2) for 4 and 11 days were examined for their functional capabilities in comparison with those of peripheral blood mononuclear cells (PBM) in 25 patients with gastric carcinoma. The cytotoxic activity of LAK cells induced from LNC for 4‐day culture with IL 2 was significantly lower than that from PBM. However, the LNC‐LAK cytotoxicity was markedly increased up to almost the same level as that of PBM after 11‐day culture. The production of interferon‐γ (INF‐γ) and tumor necrosis factor‐α (TNF‐α) from nonadherent LAK cells in LNC was also significantly reduced as compared to that from PBM 4 days after culture, when stimulated with or without tumor target, Raji cells. After 11‐day culture with IL 2, however, the levels of these cytokines produced by LNC‐LAK cells either with or without stimulation by tumor target were comparable to those by PBM‐LAK cells, although the release of these cytokines was markedly reduced when compared to that after 4‐day culture. Phenotypic analysis revealed decreased proportion of cells mediating NK activity in LNC before and 4 days after culture. CD56+and CD57+cells in LNC were increased after 11‐day culture, although the percentages of these cells were still low as compared to those in PBM. The proportions of OKIal+and CD25+cells were uniformly increased after 4 and 11‐day culture in both cell populations. Changes in subpopulations of CD4+and CD8+cells in LNC were not apparently different from PBM. These results indicated the differential LAK cell function of cells from regional lymph nodes from PBM in patients with gastric ca

ISSN:0022-4790    

DOI:10.1002/jso.2930580110

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1995

数据来源: WILEY

摘要:

AbstractTwenty‐four previously untreated patients with primary inoperable squamous cell carcinoma of the esophagus showing no evidence of hematogenous metastasis were treated with concurrent chemotherapy and radiation therapy (CRT) followed by surgical resection if possible. The chemotherapy regimen consisted of 5‐fluorouracil 750 mg/m2on days 1–4 and 21–24, and cisplatin 70 mg/m2on days 1 and 21. Radiation therapy was administered over days 1–26 (200 cGy/day five times per week with an initial planned dose of 40 Gy). Five patients (8%) showed complete response (CR), 14 patients (58%) had partial response (PR), and 19 had good local control (CR 2, PR 17). Eleven cases (48%) underwent esophageal resection with no operative mortality. Curative resection was accomplished in eight cases (35%). Toxicities observed in CRT were leukopenia (grades 3 and 4) 38%, nausea and vomiting (grades 2 and 3) 67%, esophagitis 42%, and fever 42%. The median survival time (MST) for 11 neoadjuvant cases was 349 days (P<0.05) compared to 212 days for palliative treatment (six cases) and 126 days for no treatment (six cases) after CRT. The MST of eight patients who received curative resection had not been reached after a 17‐month median follow‐up time. Concurrent chemotherapy with 5‐fluorouracil plus cisplatin and radiation proved to be a safe regimen yielding a satisfactory response and minimal toxicity in this particular group of patients. Extensive surgery was thus determined to be feasible after CRT and to contribute to prolonging survival. © 1995

ISSN:0022-4790    

DOI:10.1002/jso.2930580111

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1995

数据来源: WILEY