摘要:

AbstractB16 melanoma was studied in syngeneic C57BL/6J mice as a therapeutic model of melanoma. The irregular behavior of tumor after trochar passage was eliminated by serial intraperitoneal passage, but abundant melanin production was maintained. Mean viability of dispersed suspensions was 56%. Median survival time after injection of 107cells intraperitoneally was 11‐16 days (average 13.20).In vivodoubling time was estimated at 3.24 days. Tenfold increase time was approximately 10.75 days. Preliminary studies with rabbit antiserum demonstrated possible enhancement after incubation with tumorin vitro, and a possible therapeutic effect after administrationin viv

ISSN:0022-4790    

DOI:10.1002/jso.2930030104

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1971

数据来源: WILEY

摘要:

AbstractKinetic studies of I131‐labeled rat anti‐Walker 256 antibodies are described. The anti‐tumor antibody is a 7S globulin. The presence of tumor diminishes the level of circulating antibody. When the tumor is removed, the antibody level rises to a measurable amount. Ouchterlony in‐gel diffusion studies as well as I131‐globulin uptake data on subcellular tumor fractions indicate that the antigen is probably located on the cell membrane. Whether the antigen studied is a transplantation rather than tumor‐specific type was not determined. It is felt that the techniques described are useful for studying the human patient with autochthonous tumor as well as the cross‐immunoth

ISSN:0022-4790    

DOI:10.1002/jso.2930030105

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1971

数据来源: WILEY

摘要:

AbstractThis study establishes that the liver catalase depression in Friend virus‐infected mice is caused by a spleen‐elaborated humoral factor which is not related to bacterial products. This was shown in experiments in Friend virus‐infected germfree mice in which splenectomy resulted in return of liver catalase levels to near‐normal values. The liver catalase‐depressing factor is shown to be a true toxohormone in that it induces thymic involution when injected into healthy mice and fails to inhibit the activity of a liver catalase preparationin vitro.These findings are briefly discussed in connection with work in which ‘toxohormone‐like’ substances have been isolated from nontumor sources. Further experimentation is suggested which may help to decide whether or not true toxohormones are unique

ISSN:0022-4790    

DOI:10.1002/jso.2930030106

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1971

数据来源: WILEY

摘要:

AbstractUrinary pseudouridine excretion, which may be used as a good index of RNA turnover in the body, was measured in 25 patients who underwent hypophysectomy for advanced prostatic carcinoma. The excretion of pseudouridine was markedly elevated during the first 4 postoperative days in 9 patients who underwent open surgical hypophysectomy, but it remained essentially unchanged after stereotactic cryohypo‐physectomy in 16 patients. No correlation existed between the urinary pseudouridine excretion and the degree of ablation of pituitary function or the duration of the symptomatic remission of the disease. The body turnover of RNA was apparently not affected by gross ablation of pituitary function (plus cortisone replacement) but was moderately increased by the trauma associated with an open surgical hypophysectom

ISSN:0022-4790    

DOI:10.1002/jso.2930030107

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1971

数据来源: WILEY

摘要:

AbstractFour percent of patients with acute pancreatitis develop an acute form of respiratory overwork and die within 24 hr. To elucidate the basic physiology of this respiratory failure in a group of dogs after production of acute pancreatitis, the respiratory functions and mechanics were studied and were compared with dogs undergoing sham operation. The results showed diminished pulmonary tissue recoil accompanied by deficiency in gas exchange after acute pancreatitis. The minute respiratory volume and oxygen uptake were increased in the presence of a large pulmonary venoarterial shunt. This was associated with hypoxemia and carbon dioxide retention which could be corrected with respiratory assistance by using a volume‐controlled respirator. In clinical states any evidence of respiratory overwork and decreasedPo2should be considered as a warning sign of this malignant complication of acute pancreatiti

ISSN:0022-4790    

DOI:10.1002/jso.2930030108

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1971

数据来源: WILEY

摘要:

AbstractThe radionuclides presently available for bone imaging include Sr87m, Sr85, and F18. With any of these, the entire skeleton can be surveyed for localized bone disease by profile scanning, whole body counting, rectilinear scanning, or with the Mark II whole body scanner and positron scintillation camera. Whole body counting and profile scanning rapidly eliminate normal areas and focus attention on suspicious sites which must then be studied with a conventional scantier. Rectilinear scanning requires considerable time. The Mark II whole body scanner can survey the skeleton rapidly but not so accurately as the positron scintillation camera. The positron camera is accurate but slow. The ideal method for accurately and rapidly surveying the entire skeleton would utilize F18as the radioactive agent and a large‐crystal positron scintillation camera as the imaging devic

ISSN:0022-4790    

DOI:10.1002/jso.2930030109

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1971

数据来源: WILEY

摘要:

AbstractFor many years, the Weber‐Fergusson incision has been the standard approach for removing part or all of the maxillary sinus. Exposure is excellent and cosmetic results are generally gratifying. As our experience with these procedures has increased, we have found that the lower half or two thirds of the maxilla can be just as easily resected transorally, avoiding any facial incision. The initial incision is made in the gingivo‐buccal sulcus and is extended beyond the midline to include some of the sulcus on the contralateral side. The nasal cartilages are cut and the soft tissues of the middle one third of the face can be lifted up like a curtain to expose the maxilla. For lesions of the entire maxilla involving the orbital plate and requiring orbital exenteration, the only facial incision required is a 6–8 cm transverse extension from the lateral angle of the palpebral fissure. The bridge of soft tissue bounded by the mouth below and the palpebral fissure plus the lateral extension above can be retracted up and down to expose the underlying maxilla during its excision. Any risk of poor reapproximation of the lip with notching is avoided. These approaches are especially valuable if heavy radiation predisposing to incisional breakdown has preceded oper

ISSN:0022-4790    

DOI:10.1002/jso.2930030110

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1971

数据来源: WILEY

摘要:

AbstractAnephric male and female patients maintained on chronic hemodialysis programs have significant levels of extrarenal erythropoietin (ESF) activity. This extrarenal ESF activity is responsive to sustained high‐dose androgen treatment. However, the response cannot be maintained, and this is also reflected in the hematocrit and hemoglobin levels. A rebound or ESF overshoot was observed after androgen therapy in renoprival patients as well as in a uremic patient with intact and diseased kidneys. Extrarenal ESF is not only detectable in plasma but also in thoracic lymph fluid from anephric patients subjected to androgen therap

ISSN:0022-4790    

DOI:10.1002/jso.2930030111

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1971

数据来源: WILEY

摘要:

AbstractStudies of Fe59incorporation into blood, liver, and spleens utilizing ‘cooked’ red blood cells labeled with 59‐ferrous citrate were undertaken to evaluate iron reutilization. Intraperitoneal transplantation of intact spleens was performed from mice both with and without turpentine abscess to similarly prepared mice. Presence or absence of abscess in the recipient mouse determined ‘compartmentalization’ of reutilizable iron between the recipient reticuloendothelial system (spleen and liver) and blood. Reduced iron reutilization induced by chronic inflammation seems to be predominantly due to alteration of reticuloendothelial system function as measured by Fe59incorporation into blood from labeled ‘cooked’ red blood cells. The model studied shows that chronic inflammation is sufficient systemic cause for reduced iron reutilization and thereby a major contributor to the anemia of chr

ISSN:0022-4790    

DOI:10.1002/jso.2930030112

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1971

数据来源: WILEY

摘要:

AbstractThirty female Lewis‐Wistar rats, each 150–200 g, received equal amounts of chemically induced transplantable mammary tumor. Fifteen of the rats received a daily intraperitoneal injection of 600 mg L‐fucose, while the remaining 15, serving as controls, received saline. The injections were begun the day of tumor implantation and continued for a total of 10 days. All animals were sacrificed on the fifteenth day, Tumor growth, as determined by mean diameter, was significantly suppressed in the experimental group. Serum and tumor levels of fucose were increased in the treated animals as compared to the control animals. These findings suggest retention of fucose, which may play a role in the inhibition of growth of this mammary

ISSN:0022-4790    

DOI:10.1002/jso.2930030113

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1971

数据来源: WILEY