摘要:

AbstractThe lifespan of BDF mice with ascitic L1210 leukemia is more than doubled when they are treated with a single subcutaneously or intraperitoneally implanted sustained release cytosine arabinoside capsule. These capsules are drug‐polymer composites, with dimensions of 1.0 cm in diameter and 0.15 cm in thickness, and a drug content of 17 ± 3 mg each. Blank silicone rubber discs implanted intra‐peritoneally or subcutaneously in the leukemic mice produced no beneficial effects. Control healthy mice receiving the ARA‐C releasing capsules continued to live with no obvious signs of drug toxicity. In vitro release of ARA‐C from the discs was measured. Drug release was maintained above 20 micro‐grams per day for more than 35 days. ARA‐C extracted from discs recovered from implant studies showed that less than 16% of the total drug content was rele

ISSN:0022-4790    

DOI:10.1002/jso.2930100102

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1978

数据来源: WILEY

摘要:

AbstractAn aneurysmal bone cyst is a benign, locally aggressive bone process which frequently recurs after excochleation. Excochleation can be extended without loss of bone tissue by making use of cryosurgery. This combined technique was used in the treatment of 5 patients, without complications. None of the patients described had a demonstrable recurrence 12–60 (average 35) months after this combined therap

ISSN:0022-4790    

DOI:10.1002/jso.2930100103

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1978

数据来源: WILEY

摘要:

AbstractPCO, an aqueous‐alcoholic extract of the yeast, Saccharomyces cerevisiae, was found to inhibit mitoses of 4 different ascites tumors removed from mice. Carried as established in vitro lines 6 tumors and 4 established lines of non‐neoplastic cells could not be inhibited by PCO. Primary cultures (diploid) of mouse embryo tissue cells and granulocytic blast cells from adult mice also could not be mitotically inhibited by

ISSN:0022-4790    

DOI:10.1002/jso.2930100104

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1978

数据来源: WILEY

摘要:

AbstractThe evaluation and treatment of an intraoral lesion over a period of 8 years is presented. Clinical appearance and course, microscopic findings, and response to treatment were consistent with a diagnosis of basal cell carcinoma of the mucous membrane. Current theories of histogenesis and the biological behavior of basal cell lesions are discussed.

ISSN:0022-4790    

DOI:10.1002/jso.2930100105

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1978

数据来源: WILEY

摘要:

AbstractDuring the 10‐year period from 1966–1975, 250 patients with various head and neck cancers were treated by intra‐arterial chemotherapy using single agents or various combinations. Only 15 patients showed response of I‐C category according to Karnofsky's criteria, and 100 patients had I‐B response. Another 100 patients showed I‐A category of response and 35 patients had progressive disease out of which 5 patients exhibited excessive toxicity to drugs, eventually succumbing to it. A majority of patients in nonresponding (O‐O) category and I‐A category were earlier treated by radiotherapy, and intra‐arterial chemotherapy was given for recurrent disease. The responses were relatively good whenever chemotherapy was given as a primary treatment before surgery and radiotherapy. Again response was additive when chemotherapy was given concurrently

ISSN:0022-4790    

DOI:10.1002/jso.2930100106

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1978

数据来源: WILEY

摘要:

AbstractSerum fucose determinations were performed on 19 patients with “stable” or “inactive” malignancies, 33 patients with “active” malignancies, and 14 “normals.” A significant difference in the values between “normal” and “stable” patients and those with “active” cancer is shown. A role for this relatively simple serological test for diagnosing and following met

ISSN:0022-4790    

DOI:10.1002/jso.2930100107

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1978

数据来源: WILEY

摘要:

AbstractSix children with grade II astrocytomas were treated with combination chemotherapy consisting of 1,3 bis(2‐chloroethyl) 1‐nitrosourea (BCNU), Vincristine (VCR), intrathecal Methotrexate (i.t. MTX), and Dexamethasone. Of the children, 3 showed a partial remission, and 1 other showed clinical improvement. Our data suggest that chemotherapy is effective in low‐grade astrocytomas, and there is now a need for larger trials in low‐grade astrocytomas to document the role of chemotherapy accurately in these tumors. It is suggested that trials of chemotherapy as adjuvant to surgery and radiotherapy should be in

ISSN:0022-4790    

DOI:10.1002/jso.2930100108

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1978

数据来源: WILEY

摘要:

AbstractWe dwell upon the importance of percutaneous biopsy in the diagnosis of endothoracic masses, comparing the results of the cutting needles to those of the fine needle aspiration biopsy.We began utilizing the Vim‐Silverman needle with good results (73.7% diagnoses) and a small number of complications, only 1 of which needed treatment, but in the light of the severe and lethal complications described in the literature, we came to prefer the use of the fine needle aspiration technique, which provided good results, too, (74% diagnoses) and enlarged the diagnostic range of the percutaneous biopsy of the lung in cases of deep, or mediastinal masses.We also hold that the use of cutting needles should not be given up: in fact when a technically good smear from an aspiration biopsy does not allow a diagnosis, we usually repeat the biopsy using a cutting needle, if there is no contraindicatio

ISSN:0022-4790    

DOI:10.1002/jso.2930100109

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1978

数据来源: WILEY

摘要:

AbstractExcretory urography was performed routinely in 504 patients with sarcoma, melanoma, pelvic, head and neck, or other localized tumors over a 5‐year period. There were benign abnormalities in 14.4% of the patients examined, tumor associated abnormalities in 10.7%, and 1.4% false positives. The diagnosis of a benign lesion did not change cancer therapy in any patient. Findings on excretory urography were valuable in the management of patients with pelvic and intra‐abdominal tumors. In these patients ureteral obstruction was always caused by tumor. There was a high rate of false positivity in non‐abdominal tumors. No second primary tumors were

ISSN:0022-4790    

DOI:10.1002/jso.2930100110

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1978

数据来源: WILEY

摘要:

AbstractA study of the effectiveness of preoperative radiation as an adjuvant for surgery for patients with invasive bladder carcinoma revealed a subpopulation of patients having advanced disease who could not benefit from radiation treatment. The effect of such a group of patients on the efficiency of 2 common nonparametric tests is investigated here. Both Gehan's tests and Greenwood's tests were shown to have a very low efficiency when compared with a parametric test when this group of patients is present.

ISSN:0022-4790    

DOI:10.1002/jso.2930100111

出版商:Wiley Subscription Services, Inc., A Wiley Company    

年代:1978

数据来源: WILEY