摘要:

Abstract:In order to investigate the sympathetic nervous function of the aged, the skin potential reflex (SPR) and serum dopamine‐β‐hydroxylase activity (SDBH) were examined in 25 healthy aged and 25 healthy young subjects. In the case of the SPR, the reflex to sound stimuli was analyzed and the following results were obtained: (1) the aged group habituated more rapidly than the young group, (2) the amplitude of the SPR in the aged group was lower than that of the young, and (3) the negative wave of the SPR appeared more dominantly in the aged than in the young group. These results indicated that the sympathetic activation level of the aged decreased in comparison with that of the young. On the other hand, SDBH showed no difference between the aged and young. This discrepancy between the SPR and SDBH is discu

ISSN:1323-1316    

DOI:10.1111/j.1440-1819.1981.tb00196.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

Abstract:With SEPs recorded from age‐matched normal human subjects, 100 males and 100 females, 22.34 ± 1.69 years, it was confirmed that the Group Mean SEP of each sex each converges to a given waveform which significantly differed from each other. The waveform of the Group Mean SEP for females consisted of the 12 components, and was approximately tetraphasic within 500 msec in latency, while that for males consisted of the same components except for N4and P4. There was a high convex arch with P4(82 msec) between P2and N6for females, but a low hollow slope without the peak for males. With Scaled SEPs, which were converted from SEPs by Amplitude Scaling, the results similar to those with SEPs were obtain

ISSN:1323-1316    

DOI:10.1111/j.1440-1819.1981.tb00197.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

Abstract:With 200 SEPs of normal human subjects, the differences in the Group Mean SEP between sexes were denned, removing those attributable to the peripheral factor, the statures.The differences in baseline amplitude in the sections roughly 1) between 29–110 msec, where there were the most remarkable differences in the waveform of the Group Mean SEP, between P2and N6, with a high convex arch peaking at P4(80 msec) for females but not for males, 2) around 320 msec, and 3) behind 400 msec in latency, were verified, not attributable to the different statures, and might be the central origin.With Scaled SEPs, which were converted from SEPs by the Amplitude Scaling, results similar to those with the unsealed SEPs were obtaine

ISSN:1323-1316    

DOI:10.1111/j.1440-1819.1981.tb00198.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

Abstract:A 51‐year‐old male has suffered the gradual onset of difficulty with memory, concentration and cognition at age 50. He has progressively developed severe dementia accompanied by muscle wasting and fasciculation prominent in the upper arms and shoulders and the bulbar muscles. EMG and muscle biopsy revealed denervation patterns and a CT‐scan showed moderate cerebral atrophy. Cases of presenile dementia with motor neuron disease reported in Japan have been reviewed and the possibility of a new clinico‐pathologic entity is di

ISSN:1323-1316    

DOI:10.1111/j.1440-1819.1981.tb00199.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

Abstract:An adolescent girl showed the apparent Capgras syndrome in the course of wake‐amine induced psychosis. The patient, then 18, committed homicide in close connection with the syndrome and also with the distorted judgment due to personality immaturity. As far as the syndrome was concerned, the extension was so extreme that it involved her neighbors and even her dwelling city. The detailed case history was reported along with a discussion about the psychodynamis

ISSN:1323-1316    

DOI:10.1111/j.1440-1819.1981.tb00200.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

Abstract:The brains of 55 schizophrenic patients and 65 controls were examined using computerized tomography scans. The width of the inter‐hemispheric fissure and the third ventricle, and the volume of the lateral ventricles in the schizophrenic patients were significantly larger than those obtained in the controls. The extension of the width of the interhemispheric fissure and the increase in the volume of the lateral ventricles in the schizophrenic patients were assumed to be caused not by aging but by the schizophrenic illness itself. The increase in the volume of the lateral ventricles and the area of the anterior horns of the lateral ventricles in the schizophrenic patients was assumed to be related to the schizophrenic pathogenesi

ISSN:1323-1316    

DOI:10.1111/j.1440-1819.1981.tb00201.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

Abstract:A survey of inpatient alcoholics was conducted in Okayama and Kochi prefectures in 1977 and 1979. The total number of inpatient alcoholics was 230 in Okayama and 401 in Kochi, corresponding to 5.5% and 10.7% of the total number of inpatients in psychiatric hospitals, respectively. The percentage of female alcoholics was 6.6% in Okayama and 6.5% in Kochi. By age distribution, the percentage of elderly alcoholics was high, but young alcoholics in their 20's were extremely few. As for the marital state, the spouseless situation showed a high percentage. Regarding the defrayment of medical expenses, half of the patients were on relief. Alcoholics staying in hospital for a year or longer accounted for nearly one‐half of the cases. Classification of the subtypes of alcoholism revealed that the problem drinking group accounted for the majority with over 60%, indicating that many cases of social problems were brought to the hospita

ISSN:1323-1316    

DOI:10.1111/j.1440-1819.1981.tb00202.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

Abstract:The effects and side‐effects of psychotropic drugs are determined by many variables, and the host factor is one of the most important. A lower sensitivity of schizophrenics than normals to the sedative effect of chlorpro‐mazine and of manic depressives to imipramine were demonstrated quantitatively by a higher percent time of waking EEG following medication. The mean therapeutic dose of chlorpromazine for the manic state was found to be much lower in Japanese than in Western populations in a controlled study comparing the antimanic efficacy of carbamazepine and chlorpromazine. A lower therapeutic dose in Asian populations has been reported also on other antipsychotic drugs, lithium, and tricyclic antidepressants. The lower therapeutic dose level was discussed from the standpoint of transcultural psy‐chopharmac

ISSN:1323-1316    

DOI:10.1111/j.1440-1819.1981.tb00203.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

Abstract:A neuropathologic study, chiefly cerebrovascular lesions and degenerative changes, was conducted on the brains of 233 subjects 50 years of age and over among 557 autopsy cases of RERF‐ABCC Hiroshima in 1972–1974. There were some discrepancies between the principal clinical diagnosis and principal pathologic diagnosis in cerebrovascular disease. For cerebral hemorrhage, 8.6% were accounted for in the clinical diagnosis of the entire subjects while only 2.1% were accounted for in the pathologic diagnosis of the same subjects. The degenerative changes in the central nervous system have been increasing with age and these changes were seen more in the females than in the males. Intracerebral arteriosclerosis of a moderate extension or more existed in 36.5% of the subjects and the frequency of this disease increased with age. The frequency of cerebral infarct increased with age. The location of the infarcts was most often seen in the basal ganglia and cortex of cerebrum, the size of the cortical infarct was within 0.5 cm in diameter and multiple. The vascular lesions or degenerative changes were seen in about 74% of the brains of 50 years and o

ISSN:1323-1316    

DOI:10.1111/j.1440-1819.1981.tb00204.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

Abstract:The experimental epileptogenic focus produced by cobalt‐gelatine stick implantation in the cerebral cortex of rabbits has been studied by electron microscopy. Since our cobalt focus was latent, the bemegride maneuver was intravenously performed to identify the cobalt lesion of the cortex as an epileptogenic focus. The cobalt lesion comprised three different zones. Of the three zones, the reactive zone showed a glio‐mesenchymal scar and prominent ultrastructural changes. The major change of this zone was found in the neurons, neuropils and astrocytes. Electron‐lucent neurons deprived of the usual neuropils surrounding them, widening of extracellular spaces and swollen dendrites in neuropils, and proliferating astrocytes were observed constantly throughout the experimental period. These findings may be significant for the genesis of this type of epi

ISSN:1323-1316    

DOI:10.1111/j.1440-1819.1981.tb00205.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY