ISSN:1051-2144    

出版商:OVID    

年代:1991

数据来源: OVID

ISSN:1051-2144    

出版商:OVID    

年代:1991

数据来源: OVID

ISSN:1051-2144    

出版商:OVID    

年代:1991

数据来源: OVID

摘要:

Osteoporosis and its consequences are a major public health problem. Osteoporosis is a difficult therapeutic challenge for the endocrinologist. The questions of who needs treatment and what the treatment should be are unresolved. This short review will examine the available therapies for osteoporosis. Based on a mechanistic understanding of a specific therapy indications will be developed for each. A scheme for evaluating the osteoporotic patient and planning a treatment strategy will be proposed.

ISSN:1051-2144    

出版商:OVID    

年代:1991

数据来源: OVID

摘要:

To determine the nature and frequency of acute complications associated with the use of insulin infusion devices, we followed approximately 200 patients with Type I diabetes using insulin pumps over a period of five years. Nearly all data were collected prospectively as we managed patients in a clinical practice setting. Our findings indicated that when patients changed from conventional injections to pump therapy, glycated hemoglobin concentrations were improved without an increase in frequency of severe hypoglycemia. Infections at infusion sites were a unique problem with insulin pump therapy, and discomfort at infusion sites was the most common reason cited by patients for discontinuation of treatment with an insulin pump. The frequency of ketoacidosis increased when patients changed from conventional injections to pump therapy. Interruption of insulin delivery by plugging of infusion tubing or leakage from the tubing assembly was a common occurrence and was probably related to some of the episodes of ketoacidosis during pump therapy. Data from selected related studies are included in this review.

ISSN:1051-2144    

出版商:OVID    

年代:1991

数据来源: OVID

ISSN:1051-2144    

出版商:OVID    

年代:1991

数据来源: OVID

摘要:

Diet is the primary therapy for hyperlipidemia of any cause. This review will examine the effects of the various components of the diet on the plasma cholesterol concentration and, thereby, develop a foundation upon which to devise a rational dietary strategy for the treatment of one of America's most prevalent health care problems.

ISSN:1051-2144    

出版商:OVID    

年代:1991

数据来源: OVID

摘要:

The TRH test has played an important role in the -diagnosis of subtle or-subelinical-hyperthyroidism. This use of the test has now been largely supplanted by the new sensitive TSH assays. The TRH test still has a role in identifying patients with suppressed serum TSH concentrations secondary to nonthyroidal illness, and may prove to- be useful in monitoring surgical success in patients with acromegaly.

ISSN:1051-2144    

出版商:OVID    

年代:1991

数据来源: OVID

摘要:

The most common cause of death for older American women is cardiovascular disease. Before menopause, women are protected against cardiovascular disease by an estrogen-dominant milieu. This is evidenced by a favorable lipoprotein profile. After menopause the circulating lipoproteins move toward a more atherogenic profile. Estrogen replacement therapy in the postmenopausal years is associated with a 50|X% (ever-users) to 70|X% (current users) reduction in the risk of coronary heart disease and stroke. The mechanism for this protection against cardiovascular disease by estrogen is partly through a beneficial impact on the lipoprotein profile and partly through a direct effect on arterial vessels. The addition of a progestational agent to an estrogen replacement program is necessary to prevent endometrial cancer. A contemporary method of hormone replacement uses a daily combination of estrogen with a small dose of progestin. This method improves compliance by avoiding withdrawal bleeding. Evidence is accumulating that this small progestational dose can protect the endometrium and avoid a significant negative impact on lipids and the lipoprotein profile.

ISSN:1051-2144    

出版商:OVID    

年代:1991

数据来源: OVID

摘要:

Because treatment with thyroid hormone has been reported to reduce bone mineral density, health care providers and patients alike have become confused and alarmed in regard to risks of osteoporosis and potential bone fracture. In this review, the available data bearing on this issue are briefly described and a rational approach to management is proposed. When considering thyroid hormone treatment, the clinician must weigh the indications for such therapy against possible adverse effects on bone mineral, and be cognizant of the distinction between replacement and suppressive therapy, since there is accumulating evidence to indicate that even mild degrees of chronic excess of thyroid hormone therapy may accelerate the natural course of osteoporosis. Current and future experimental protocols in patients tak-potential benefit of adjunctive agents that inhibit bone resorption such as calcitonin or organic biphosphonates. For the time being, however, enlightened use of the new highly sensitive thyrotropin assays will allow the physician to lower the risk of osteopenia in patients taking thyroid hormone.

ISSN:1051-2144    

出版商:OVID    

年代:1991

数据来源: OVID