摘要:

AbstractForty-four patients with previously untreated advanced lung cancer were randomized to receive radiochemotherapy (RC) or radiochemotherapy plus MER/BCG (RCM). Prior to immunotherapy administration cutaneous reactivity to 5 log dilutions of MERIBCG was determined starting at 100μg per injected site to 10 sites. Reactive patients were injected with 10, 1.0, or 0.1μg while anergic patients were given 200 or 100μg to each of 10 cutaneous sites, the dose being inversely related to the strength of the pretreatment reaction. Injected doses were subsequently further increased or decreased to achieve tolerable local erythema and induration. This modification resulted in a marked reduction in cutaneous toxicity previously observed, and made it possible to nearly double the mean number of MER courses per patient. It is suggested that intrademl MER/BCG may prove to be a considerably more useful therapeutic agent if doses are adjusted to patients' individual cutaneous responsiveness.

ISSN:0735-7907    

DOI:10.3109/07357908709020299

出版商:Taylor&Francis    

年代:1987

数据来源: Taylor

摘要:

AbstractTumor tissue samples from 25 patients with adenocarcinoma of the colon, twelve related samples of normal colons as well as five serum specimens from the same patients were analyzed for ferritin. The average ferritin content of the tumor tissue was 788 ng/mcp1with a range of 47–1,745 ng/mcp. The average ferritin content of normal colon mucosa was 115 ng/mcp with a range of 32–230 ng/mcp. Two specimens of metastatic colon cancer taken from the retroperitoneal space and liver, respectively, contained 3,867and 2,827 ng/mcp of ferritin. The ferritin content of the tumor tissue was higher than that of the normal colon in 8 of 9 patients who had specimens obtained from both sites. me amount of ferritin found in tumor tissue was independent of sex, age, and the site of the original tumor. This study shows that the ferritin content of colon neoplasms is elevated and indicates that the tumor tissue may be the direct source of elevated serum levels of ferritin previously observed in cancer patients.

ISSN:0735-7907    

DOI:10.3109/07357908709020300

出版商:Taylor&Francis    

年代:1987

数据来源: Taylor

摘要:

AbstractEight beagle dogs received [3H]VP 16–213 at 2 mg/kg administered intravenously (IV) or intra-arterially (IC) through a catheter inserted into the internal carotid artery. Blood, urine, bile, and cerebrospinal fluid (CSF) samples were collected at intervals. At 1, 6, 24 hr, and 2 weeks after drug administration the dogs were sacrificed and the major organs analyzed for drug concentration. VP 16–213 concentration was determined by radiochemical assay and high pressure liquid chromatography. The plasma t1/2in the IC group of dogs was 1.0 hr, the volume of distribution was I.7 L/kg and the clearance was 1.5 ml/hr/kg. In the IV group the values were 1.7, 3.9, and 1.6, respectively. The CSF concentration peaked at I hr by both routes, but was higher at all time points in the IC group. At 24 hr and 2 weeks after IC VP 16–213, drug concentration in brain tissue was at least four times higher in the IC group compared with the IV group. In extracranial organs the reverse was true, with the bone marrow cell concentration 1.6 times higher by IV compared to IC (267.2 ng/g and 164.5 ng/g, respectively). Two major and one minor metabolites were found in plasma, urine, bile, and tissue by both routes, however, not all metabolites were found in all organs and body fluids. No acute neurologic toxicity was noted in the IC group and no histopathologic changes by light microscopy were found in the brain or other organs. IC VP 16–213 produced higher drug concentration in the brain of dogs compared with IV administration and was well tolerated at the dosage used.

ISSN:0735-7907    

DOI:10.3109/07357908709020301

出版商:Taylor&Francis    

年代:1987

数据来源: Taylor

摘要:

AbstractHuman tumor cell lines, a rhabdomyosarcoma (RD), and ajbrosarcoma (HT-1080) were distinguished from normal human jbroblasts by tumorigenicity in athymic nude mice and immunosuppressed rats and hamsters, secretion of different types of collagen and procollagen molecules, and reduced amounts ofjbronectin. The jbronectins secreted by both normal and tumor cells did not show any signijcant structural difference and were phosphorylated only on senne residue(s). However, Fibronectin secreted by the tumor cells exhibited decreased electrophoretic mobility and was associated with as yet unidentified phosphorylated macromolecules.

ISSN:0735-7907    

DOI:10.3109/07357908709020302

出版商:Taylor&Francis    

年代:1987

数据来源: Taylor

摘要:

AbstractIn malignant cells the amino groups of cellular proteins are alkylated by homocysteine thiolactone, forming homocysteinyl peptide bonds. In nonnal cells the sulfur atom of homocysteine thiolactone is converted to homocysteic acid, phosphoadenosine phosphosulfate, and sulfate ester. N-substituted derivatives of homocysteine thiolactone synthesized from arachidonic acid, pyridoxal, and maleimide were previously found to have antineoplastic activity. Another N-substituted derivative, the rhodium trichloride complex of oxalyl homocysteine thiolactone, was synthesized and tested for antineoplastic activity. Mice with transplanted rhabdomyosarcoma were injected with solutions of the complex dissolved in lipids. Doses of 50 and 100 mg/kg per day for two weeks produced 50% inhibition of tumor growth. At doses of 100 and 200 mg/kg per day in tumor-free inice there was decreased survival, peritoneal reaction, pigment deposition in lung, jibrocalcijc pericarditis, and leiomyosarcoma of colon (in one animal). The conclusion is that the complex of rhodium trichloride and oxalyl homocysteine thiolactone possesses antineoplastic activity.

ISSN:0735-7907    

DOI:10.3109/07357908709020303

出版商:Taylor&Francis    

年代:1987

数据来源: Taylor

ISSN:0735-7907    

DOI:10.3109/07357908709020304

出版商:Taylor&Francis    

年代:1987

数据来源: Taylor

ISSN:0735-7907    

DOI:10.3109/07357908709020305

出版商:Taylor&Francis    

年代:1987

数据来源: Taylor

ISSN:0735-7907    

DOI:10.3109/07357908709020306

出版商:Taylor&Francis    

年代:1987

数据来源: Taylor

ISSN:0735-7907    

DOI:10.3109/07357908709020307

出版商:Taylor&Francis    

年代:1987

数据来源: Taylor

ISSN:0735-7907    

DOI:10.3109/07357908709020308

出版商:Taylor&Francis    

年代:1987

数据来源: Taylor