摘要:

AbstractThe synthesis of dimethyl‐[35S]sulphide in high yield from the contact of hydrogen‐[35S]sulphide and methanol over a γ Al2O3.1% SiO2catalyst is described. The procedure produces high yields of dimethyl‐[35S] sulphide of low specific activity compared to that of the hydrogen‐ [35S]sulphide starting

ISSN:0362-4803    

DOI:10.1002/jlcr.2580200102

出版商:John Wiley&Sons, Ltd.    

年代:1983

数据来源: WILEY

摘要:

AbstractDans le but de réaliser des études de disposition et de métabolisme le CNCC a été marqué par35S,14C, et3H en trois positions:‐ on the two sulfur atom of the cystamine group‐ on the urea carbonyl‐ on the position 1 of the 2 chloro

ISSN:0362-4803    

DOI:10.1002/jlcr.2580200103

出版商:John Wiley&Sons, Ltd.    

年代:1983

数据来源: WILEY

摘要:

AbstractRadioactive methane of high specific activity was easily prepared using growing cultures or resuspended frozen cells ofMethanobacteriumthermoautotrophicum. This method gave a greater than 90% conversion of the substrate “14CO2”No distinctions are made between CO2, HCO3−and CO3=when the symbol “CO2” is used.into14CH4using H2as a reductant, and is also applicable to the productio

ISSN:0362-4803    

DOI:10.1002/jlcr.2580200104

出版商:John Wiley&Sons, Ltd.    

年代:1983

数据来源: WILEY

摘要:

AbstractA 20.4 mCi sample of 99% radiochemically pure 3,6‐dichloropicolinic acid‐2,6‐14C with a specific activity of 11.6 mCi/ mmole was synthesizedviaa five step process from glutarimide‐ 2

ISSN:0362-4803    

DOI:10.1002/jlcr.2580200105

出版商:John Wiley&Sons, Ltd.    

年代:1983

数据来源: WILEY

摘要:

AbstractStable isotope substituted spin labels increase the resolution and sensitivity of EPR measurements. An improved synthesis of15N‐(1‐oxyl‐2,2,6,6‐tetramethyl‐ 4‐piperidinyl)maleimide has been devised and utilized. This improved synthesis is accomplished in five steps instead of the normally required se

ISSN:0362-4803    

DOI:10.1002/jlcr.2580200106

出版商:John Wiley&Sons, Ltd.    

年代:1983

数据来源: WILEY

摘要:

Abstractβ‐casomorphin‐5, tyrosyl‐prolyl‐phenylalanyl‐prolyl‐glicine, labelled with14C and3H in the N‐terminal tyrosine residue, was synthesized by stepwise elongation, using [Dit]1‐β‐casomorphin‐5 as precursor for catalytic tritiation. The specific radioactivities of the two peptides were 1.6 mCi/mmol [59.2 MBq/mmol] and 44.1 Ci/mmol [1.63 /Bq/mmol], respectively. Both were biologically fully active as compared with a synthet

ISSN:0362-4803    

DOI:10.1002/jlcr.2580200107

出版商:John Wiley&Sons, Ltd.    

年代:1983

数据来源: WILEY

摘要:

AbstractSite specific deuterated primaquines were prepared. The attempts to prepare these by deuterolysis of bromoprimaquines were unsuccessful because the required bromoprimaquines could not be produced satisfactorily by alkylation of the various bromo‐6‐ methoxy‐8‐aminoquinolines. Instead primaquines deuterated at positions 2, 3 and 4 were obtained by alkylation of site specifically deuterated 6‐methoxy‐8‐aminoquinoline. 5‐Deuteroprima‐ aquine was obtained by deuterolysis of the corresponding 5‐bromo compound and 7‐deuteroprimaquine was obtained by ac

ISSN:0362-4803    

DOI:10.1002/jlcr.2580200108

出版商:John Wiley&Sons, Ltd.    

年代:1983

数据来源: WILEY

摘要:

Abstract21‐Fluoropregnenolone‐3‐acetate‐21‐18F (4b) and 21‐fluoropregnenolone‐21‐18F (8) were synthesized by nucleophilic substitution of the iodo group of the corresponding 21‐iodo analogs by F‐fluoride in an acetonitrile solution of 18‐Crown‐6. 21‐Fluoropregnenolone‐3‐acetate‐ 7‐3H (10b) and 21‐fluoropregnenolone‐7‐3H (9b) were synthesized by reacting 21‐ethoxalyl pregne

ISSN:0362-4803    

DOI:10.1002/jlcr.2580200109

出版商:John Wiley&Sons, Ltd.    

年代:1983

数据来源: WILEY

摘要:

AbstractA selective serotonin S2receptor antagonist, ketanserin, was prepared labeled with carbon‐11 by a rapid synthesis which uses no‐carrier‐added phosgene as the labeled precursor. The ring‐closure reaction in toluene of phosgene with the substituted 2‐aminobenzamide precursor gives a nearly quantitative yield of ketanserin. The 30 min procedure yields 150 mCi of HPLC purified ketanserin at a specific activity of 250 mCi/μ mol. The product's tissue distribution in mice shows a brain uptake and cerebrum to cerebellum ratio that encourages furtherin vivoreceptor bindi

ISSN:0362-4803    

DOI:10.1002/jlcr.2580200110

出版商:John Wiley&Sons, Ltd.    

年代:1983

数据来源: WILEY

摘要:

Abstract[1‐13C]1‐Cyanocyclohexene can be bisbrominated by N‐bromosuccinimide and then aromatized by triethylamine to give [1‐13C] benzonitrile in 90% yield. This allylic bisbromination‐dehydrobromination reaction is generally applicable to the transformation of other 1‐substituted cyclohexenes into benzenoid

ISSN:0362-4803    

DOI:10.1002/jlcr.2580200111

出版商:John Wiley&Sons, Ltd.    

年代:1983

数据来源: WILEY