摘要:

AbstractSynthesis and organ distribution of the oxidation products of methylruthenocene up to ruthenocene acid and of various derivatives of hydroxymethylruthenocene labelled with103Ru are described. Hydroxymethylruthenocene and ruthenocenecarboxaldehyde show like ruthenocene acid a comparable organ distribution and a high affinity to the kidneys. Probable hydroxymethylruthenocene and the aldehyde are oxidizid in vivo and then excreted as acid or as conjugate via kidneys. The benzoic acid ester of hydroxymethylruthenocene enriches in the adrenals with high contrast to kidneys. Tumor affinity of all compounds tested was low.

ISSN:0362-4803    

DOI:10.1002/jlcr.2580170102

出版商:John Wiley&Sons, Ltd.    

年代:1980

数据来源: WILEY

摘要:

AbstractThe preparations of nicotin[2′,4′,6,‐2H3]anilide, 4′‐Cl‐nicotin[2′,6′‐2H2]anilide, 4′‐X‐nicotin[ar‐3H]anilide, (X = H−, CH3‐, Cl‐ or No2‐) and[6‐14C]

ISSN:0362-4803    

DOI:10.1002/jlcr.2580170103

出版商:John Wiley&Sons, Ltd.    

年代:1980

数据来源: WILEY

摘要:

AbstractThe preparation of a tritium labelled alpha‐adrenergic agonist, 2‐(4‐amino‐2,6‐dichloro 3,5‐ditritio‐phenylimino)‐imidazolidine, suitable for alpha‐adrenergic receptor membrane binding stud

ISSN:0362-4803    

DOI:10.1002/jlcr.2580170104

出版商:John Wiley&Sons, Ltd.    

年代:1980

数据来源: WILEY

摘要:

Abstract3‐(1,2‐Diphenylethyl)‐1,4,5,6‐tetrahydro‐1,2,4‐triazine‐3‐14c hydrochloride (6) with a specific activity of 25.53 mCi/mmole was prepared in a 66.1% yield from benzyl cyanide‐1‐14C via a

ISSN:0362-4803    

DOI:10.1002/jlcr.2580170105

出版商:John Wiley&Sons, Ltd.    

年代:1980

数据来源: WILEY

摘要:

AbstractMethyl‐N‐carbobenzoxy‐β‐131I‐D‐alaninate (2) was synthesized by the melt method. Partial hydrolysis of compound2gave methyl β‐131I‐D‐alaninate (3). Hydrolysis of2with2N HCl gave β‐131I‐D‐alanine. The123I and125I labelled compounds were synt

ISSN:0362-4803    

DOI:10.1002/jlcr.2580170106

出版商:John Wiley&Sons, Ltd.    

年代:1980

数据来源: WILEY

摘要:

AbstractThe different parameters of11C formaldehyde synthesis from11CO2have been systematically studied in order to improve yields, reproductibility and specific radioactivity.With modifications brought to gas and reagents purity,11CO2trapping system, target and dehydrogenation catalyst treatment, 100 to 200 mCi of11C formaldehyde are obtained at EOB + 10 mn, with a specific activity on the order of 600 mCi/μmole (maximum 1 Ci/μmole

ISSN:0362-4803    

DOI:10.1002/jlcr.2580170107

出版商:John Wiley&Sons, Ltd.    

年代:1980

数据来源: WILEY

摘要:

AbstractA radiobrominated compound, 4,5,6,7‐tetrachloro‐2′,4′,5′,7′‐tetrabromofluorescein‐77Br4was prepared from resorcinol, tetrachlorophthallic anhydride and Na77Br by a two‐step synthesis. The precursor was identified by spectrometry. Final purification utilized column chromatography. The product was identified by thin layer chromatography and spectrometry. The yield was 6

ISSN:0362-4803    

DOI:10.1002/jlcr.2580170108

出版商:John Wiley&Sons, Ltd.    

年代:1980

数据来源: WILEY

摘要:

AbstractA microscale synthesis has been developed for the preparation of 17β‐hydroxy‐2‐tellura‐A‐nor‐5α‐androstane. Reactorproduced123mTe has been used to prepare the123mTe labeled steroid. The radiochemical synthesis and purification of this potential prostate imaging agent are desc

ISSN:0362-4803    

DOI:10.1002/jlcr.2580170109

出版商:John Wiley&Sons, Ltd.    

年代:1980

数据来源: WILEY

摘要:

AbstractTritium labelled cyclohexene oxide, trans‐stilbene oxide and phenanthrene 9,10‐oxide were prepared with specific activities of 0.7 ‐ 1.1 mCi per mmole starting with monoor diketo compounds.Tritium was introduced by reducing the ketone precursors with tritiated complex metal hydrides.The resulting alcohols were transformed to the epoxides by methods described for the unlabelled compounds.The syntheses require only two or three steps and yield cyclohexene oxide, trans‐stilbene oxide and phenanthrene 9,10‐oxide, important substrates for the study of epoxide hydratase and glutathione S‐transferases in high radiochem

ISSN:0362-4803    

DOI:10.1002/jlcr.2580170110

出版商:John Wiley&Sons, Ltd.    

年代:1980

数据来源: WILEY

摘要:

AbstractTwo general schemes for the synthesis of isotope labelled monomethyl catecholamine metabolites are described. Catechol was converted to 2‐methoxy‐d3‐phenol (2) with deuteromethyl iodide and reacted with sodium glyoxylate to form 4‐hydroxy‐3‐methoxy‐d3‐mandelic acid (3). Hydrogenolysis of the methyl ester‐diacetate of 3 with excess sodium borohydride in water yielded 4‐hydroxy‐3‐methoxy‐d3‐phenylacetic acid (4). Reduction of 3 with diborane produced 4‐hydroxy‐3‐methoxy‐d3‐phenylethylene glycol (5). An alternative route was to alkylate 3,4‐dihydroxybenzaldehyde (6) and produce 3 or its 3‐hydroxy‐4‐methoxy isomer via the nitrile mandelic acid synthesis. Suitability of these isotopic and isomeric variants as internal standards for quantitation by gas

ISSN:0362-4803    

DOI:10.1002/jlcr.2580170111

出版商:John Wiley&Sons, Ltd.    

年代:1980

数据来源: WILEY