摘要:

AbstractA methods of obtaining 2‐deuteromethyl ketones by deuteromethylation of the corresponding β‐ketosters. is described and proposed as a general method for β‐deuterium labeling of

ISSN:0362-4803    

DOI:10.1002/jlcr.2580120102

出版商:John Wiley&Sons, Ltd.    

年代:1976

数据来源: WILEY

摘要:

Abstract4‐Hydroperoxyisophosphamide (II), an effective antitumor agent has been labelled with carbon‐14. The carbon‐14 label was incorporated into the C‐6 position of the molecule to give (VII). The overall radiochemical yield was 4.4% based on barium carbonate‐14C. The labelled compound obtained was used for absorption and metabolis

ISSN:0362-4803    

DOI:10.1002/jlcr.2580120103

出版商:John Wiley&Sons, Ltd.    

年代:1976

数据来源: WILEY

摘要:

AbstractA new hepatoprotective agent, N‐(2‐hydroxyethyl)‐maleopimarimidyl morpholide (RU18492) has been synthesised labelled with tritium at C‐3, C‐4a, C‐10 and in the C‐isopropyl group. The incorporation of tritium relies on the acid‐catalysed isomerisation of levopimaric acid (4) to abietic acid (2), which was then converted in thre

ISSN:0362-4803    

DOI:10.1002/jlcr.2580120104

出版商:John Wiley&Sons, Ltd.    

年代:1976

数据来源: WILEY

摘要:

AbstractThe synthesis of14C‐desmethylene aldrin (I) from14C‐Ul‐hexachloro cyclopentadiene and cyclohexa‐l,4‐dieneviaa Diels‐Alder reaction and its conversion to desmethylene dieldrin (II) and desmethylenecis(III) andtrans(IV)‐dihydrodiols

ISSN:0362-4803    

DOI:10.1002/jlcr.2580120105

出版商:John Wiley&Sons, Ltd.    

年代:1976

数据来源: WILEY

摘要:

AbstractBenzyl chloride‐7‐14C is condensed with 2‐lithio 2‐methyl 1,3‐dithianes. Deprotection with cupric chloride‐copper oxide of the resulting 2‐benzyl 2‐methyl 1,3‐dithianes leads to 1‐phenyl‐2‐propanone‐1‐14C. The latter with L(‐)α‐methylbenzylamine in presence of molecuLar sieve gives rise to (‐)N‐(α‐phen‐ethyl)phenylisopropylimine which is catalytically reduced into the corresponding amine. Hydrogenolysis of this amine gives D(+) amphetamine‐7‐14C isolated as the sulfate with an overall yield of 10 % based on be

ISSN:0362-4803    

DOI:10.1002/jlcr.2580120106

出版商:John Wiley&Sons, Ltd.    

年代:1976

数据来源: WILEY

摘要:

AbstractA widely used herbicide, 2,2‐dichloropropionic acid (dalapon), was synthesized with14C‐labeling in the C‐1 or C‐2 positions. The carboxyl labeled material was prepared in 55% yield by carbonation of 1,1‐dichloro‐ethyllithium at approximately −104°. Starting with trichloroacetic acid, the C‐2 labeled product was prepared in an overall yield of 39% by means of a 4‐step reaction sequence which involved the removal of a chlorine atom and the addition

ISSN:0362-4803    

DOI:10.1002/jlcr.2580120107

出版商:John Wiley&Sons, Ltd.    

年代:1976

数据来源: WILEY

摘要:

AbstractA simple, efficient and relatively cheap procedure for synthesising radiolabelled PGF2αfrom arachidonate or PGE2is described. The method exploits the stereospecific enzymatic reduction of PGE2by PGE2‐9‐ketoreductase from rabbit renal co

ISSN:0362-4803    

DOI:10.1002/jlcr.2580120108

出版商:John Wiley&Sons, Ltd.    

年代:1976

数据来源: WILEY

摘要:

Abstract18O‐multilabeled anhydrous nitric acid (89 atom %18O) was prepared by exchange with H218O, neutralization with NH3, and distillation from methane sulfonic acid. The use of trifluoromethane sulfonic acid, sulfuric acid, and oleum was also investigated, but these acids were found unsuitable due to rapid oxygen exchange. The extent of exchange was. monitored by converting water to methanol, nitric acid to nitroanisole, and analyzing by field ionization mass spectrometr

ISSN:0362-4803    

DOI:10.1002/jlcr.2580120109

出版商:John Wiley&Sons, Ltd.    

年代:1976

数据来源: WILEY

摘要:

AbstractFour deuterium‐labelled compounds were prepared for use as internal standards in the quantification of methamphetamine, DOM, PCP, and methaqualone at low levels in body fluids by selected ion monitoring. The need for standards containing more than three deuterium atoms per molecule and having high isotopic purity is discusse

ISSN:0362-4803    

DOI:10.1002/jlcr.2580120110

出版商:John Wiley&Sons, Ltd.    

年代:1976

数据来源: WILEY

摘要:

AbstractEs wird die Synthese von Pulvinäure‐[14C], 4′‐Hydroxy‐pulvinäure‐[14C], ausgehend von Phenylacetonitril‐[2‐14C], bschrieben. Die Identität der markierten Verbindungen wurde durch dünnschichtchtomatographischen Vergleich mit den auf glechim Wege synthetisierten inaktiven substanzen sichergestellt, deren Struktur durch Elementaranalyse, MASSEN‐,1H‐NMR‐Spektern

ISSN:0362-4803    

DOI:10.1002/jlcr.2580120111

出版商:John Wiley&Sons, Ltd.    

年代:1976

数据来源: WILEY