摘要:

Investigations with dihydroergotoxine methane sulfonate (DHET, the active substance of Redergine®) indicate that DHET acts on the sleep-wakefulness cycle of the cat by increasing wakefulness and slow-wave sleep and decreasing rapid eye movement sleep. DHET was administered intraperitoneally at a dose of 1.0 mg/kg for 5 successive days. The effects were fairly stable, although with a tendency to diminish with time. Such alterations in the sleep-wakefulness cycle are discussed as possible indices of the beneficial effects seen in elderly patients treated with DHET

ISSN:0304-324X    

DOI:10.1159/000212442

出版商:S. Karger AG    

年代:1981

数据来源: Karger

摘要:

The turnover rate of catecholamine in the cerebral cortex and caudate of adult Wistar rats was estimated after inhibition of synthesis by means of α-methyl-p-tyrosine in animals treated with dihydroergotoxine (1 mg/kg body weight daily) for 1, 3 and 10 days. Following single as well as repeated treatments with the drug, blockade of norepinephrine receptors, as indicated by the increased catecholamine turnover rate, was found in both brain structures. The turnover rate of dopamine was changed only after repeated treatments; it was decreased in the cortex and increased in the caudate, indicating both agonistic and antagonistic effects of dihydroergotoxine on dopamine receptors

ISSN:0304-324X    

DOI:10.1159/000212443

出版商:S. Karger AG    

年代:1981

数据来源: Karger

摘要:

In adult caged house flies, maintained on a complete diet of powdered whole milk, cane sugar and water, the median longevity, maximal longevity, and percentage that exhibit complete wing retention at death are increased as the number of individuals per cage is correspondingly decreased from 240 to 10 flies per cage. These effects are more marked for the shorter-lived males than for the females. Female longevities at all population densities are more significantly reduced by a restricted diet of sugar and water only. Under conditions of individual confinement, the life expectancy of the female house fly is no greater than that of the male. These results are in agreement with earlier suggestions that increased physical activity including interaction among individuals in a restricted population decreases longevity.

ISSN:0304-324X    

DOI:10.1159/000212444

出版商:S. Karger AG    

年代:1981

数据来源: Karger

摘要:

The variations of heritability as a function of parental age are studied in Koekelaere pines [Pinus nigra Arnold, subsp. laricio (Poiret) Maire, cv. Koekelaere]. The age of the parental trees varies between 26 and 101 years. 16 different traits are analysed. It is shown that heritability does not vary as a function of parental age. These results are discussed in relation with the problems of ageing in trees and of the theories of ageing.

ISSN:0304-324X    

DOI:10.1159/000212445

出版商:S. Karger AG    

年代:1981

数据来源: Karger

摘要:

Alloxan-decreased percentage solubility level of collagen in bone, skin and tendon following 4 and 28 days of treatment showed an almost complete recovery to normal levels in bone and skin after a 20-day recovery period. Alloxan effect is still maintained in tendon after repeated doses, suggesting tissue specificity of the recovery process.

ISSN:0304-324X    

DOI:10.1159/000212446

出版商:S. Karger AG    

年代:1981

数据来源: Karger

摘要:

The effect of dietary fat, carbohydrate and protein on tail tendon collagen ageing was studied in male Wistar rats. When rats were fed low-calorie diets there was no evidence that the content of carbohydrate, fat or protein affected the ageing of collagen. However, on high-calorie diets there was evidence that high-fat diets (21%) either saturated or unsaturated aged collagen fibres at a faster rate than low-fat diets (7%). Isolated housing of rats, which is necessary to control food intake, was found to slow the rate of collagen ageing. This effect was associated with reduced tail tendon temperatures.

ISSN:0304-324X    

DOI:10.1159/000212447

出版商:S. Karger AG    

年代:1981

数据来源: Karger

摘要:

In our morphological and kinesiological study, degenerative changes of the human cervical spine became more frequent and severe with advancing age. Disk splits and diarthrodial cartilage loss were the first lesions to appear. Apophyseal osteophytes arose approximately two decades after apophyseal cartilage loss, paradiscal osteophytes two decades after disk splits and irregularity of the vertebral end-plates 10–15 years after the appearance of paradiscal osteophytes. Because all these degenerative lesions are associated with loss of mobility, advancing age is correlated with decreasing cervical mobility as well. In the absence of progression of any degenerative lesion, however, no change in mobility was foun

ISSN:0304-324X    

DOI:10.1159/000212448

出版商:S. Karger AG    

年代:1981

数据来源: Karger

摘要:

The subcellular distribution of estradiol following the in vivo administration of 3Hestradiol, cytosol and nuclear estrogen receptor after in vitro incubation with 3H-estradiol were studied in young adult female rats (3–6 months old) and old female rats (over 18 months old). After intravenous injection of 3Hestradiol, with or without diethylstilbestrol pretreatment, significantly higher cytosol uptake of estradiol in the pituitary, dorsal hypothalamus and corticomedial amygdala (AMYG) with concomitant significantly lower nuclear uptake in the preoptic area (POA) and basomedial hypothalamus (BMH) and a tendency of lower nuclear uptake in AMYG and pituitary of old noncyclic (NC) rats as compared with young adult female rats were observed. The uterus of NC rats had a low ratio of milligrams of protein per milligram wet weight as compared with young rats and the nuclear binding 1 h after the injection was significantly lower than that of young rats when the value was expressed as disintegrations per minute per milligram weight but not when expressed as disintegrations per minute per milligram protein. Assays of cytosol and nuclear estrogen receptor after in vitro incubation with 3Hestradiol revealed that old prolonged vaginal cornification (PVC) rats did not react estradiol priming with increased nuclear receptors in the pooled brain tissues of AMYG, POA and BMH, anterior pituitary and uterus. These results indicate that there seems to be an impaired translocation of estradiol from cytosol to nucleus in old PVC rat

ISSN:0304-324X    

DOI:10.1159/000212449

出版商:S. Karger AG    

年代:1981

数据来源: Karger

摘要:

Hypophysectomy performed in 25- to 26-day-old Wistar rats leads within 1 year to the formation of ovarian testis-like tubes and epithelial cellular cords which are typical structures in the senile ovaries of normal 24-month-old rats. Testis-like tubes represent an unusual late stage of follicular degeneration; the origin of the cords is more complex; the revival of cell differentiation from stroma and/or rete ovarii in the absence of the pituitary is hypothesized. At 16 months of age, cords proliferate and are responsible for ovarian weight increase to almost twice the minimal weight seen 4 months after the operation. Variability in cord proliferation is considerable from one rat to another, but also between the two ovaries of the same animal. Thus, an intrinsic age-related ovarian factor is implicated in cord proliferation. From this study, it is inferred that during intact rat senescence, intrinsic ovarian aging is responsible for the proliferation of cords, whereas their induction depends on a hypothalamic-hypophyseal imbalance occurring at about 1 year of age.

ISSN:0304-324X    

DOI:10.1159/000212450

出版商:S. Karger AG    

年代:1981

数据来源: Karger

摘要:

Autopsy renal findings were correlated with clinical data during life in 100 aged people. An indwelling catheter in life was associated with raised serum creatinine and also infected renal pathology. Urinary infection itself did not correlate with serum creatinine level, systolic or diastolic blood pressure or infected renal pathology. The presence of any form of renal pathology correlated with elevated serum creatinine and elevated systolic but not diastolic blood pressure.

ISSN:0304-324X    

DOI:10.1159/000212451

出版商:S. Karger AG    

年代:1981

数据来源: Karger