摘要:

Ascending infection of the rat kidney was produced by the injection of various amounts of a culture of E. coli up the urethra coupled in some instances with gentle compression of the bladder. Quantitative bacterial and histological studies were made at different time intervals in order to study the evolution of the lesion. Acute inflammation occurred in the pelvis, calyx and peri-hilar cortex in most animals but in some it was restricted to the pelvic and calyceal mucosa. The natural history is towards healing although considerable destruction of renal parenchyma may occur before this is achieved. In the early stages local injury to the kidney in the forniceal region caused an accentuation of the infective process. The main route by which organisms reach the kidney is up the ureters although some degree of infection by the blood stream is conceivable because of the frequency with which bacteremia occurs and the way in which small numbers of organisms can reach a kidney whose ureter has been obstructed. The distribution of infection is different from that in the experimental model where intravenous injection of organisms is coupled with temporary occlusion of the ureter.

ISSN:1660-8151    

DOI:10.1159/000179321

出版商:S. Karger AG    

年代:1964

数据来源: Karger

摘要:

The injection of normal or ínfarcted homologous renal tissue induced hypertension in the rat comparable to that which follows unilateral infarction of the kidney. The serum of such rats exhibited precipitin reactions against trypsinized digests of isologous kidney and arterial tissues. The presence of anti-kidney and anti-artery components in the serum was also indicated by the binding of fluorescein-conjugated globulins to the glomerular and basement membranes and arterial components of normal kidney. Globulin was localized in the small arteries of kidneys exhibiting endarteritis and damage to the elastic membrane. Suppressants of antibody reactions (cortisone and 6-mercaptopurine) inhibited the development of hypertension following infarction of the kidney. The demonstration of the presence of anti-kidney components in the sera of certain patients with hypertension and those with renal disease suggests that this phenomena of an autoimmune reaction against renal tissue which has been induced experimentally in the rat may also play a role in human disorders. When this process affects that part of the nephron normally concerned in the maintenance of the normotensive state, hypertension ensues

ISSN:1660-8151    

DOI:10.1159/000179322

出版商:S. Karger AG    

年代:1964

数据来源: Karger

摘要:

The stop-flow technique has been applied to the dog in an attempt to rule out tubular secretion of phosphate and to locate the site of action of parathyroid hormone (P.T.H.) on the renal tubule. Under the experimental conditions used, no significant inward transtubular movement of P32 could be demonstrated, ruling out tubular secretion of phosphate. Stop-flow experiments performed in parathyroidectomized dogs before and after P.T.H. administration demonstrated inhibition of phosphorus reabsorption by the hormone. In addition, the stop-flow pattern indicated that this phenomenon took place mainly in the distal part of the proximal tubules.

ISSN:1660-8151    

DOI:10.1159/000179323

出版商:S. Karger AG    

年代:1964

数据来源: Karger

ISSN:1660-8151    

DOI:10.1159/000179324

出版商:S. Karger AG    

年代:1964

数据来源: Karger