ISSN:1660-8151    

DOI:10.1159/000179601

出版商:S. Karger AG    

年代:1967

数据来源: Karger

ISSN:1660-8151    

DOI:10.1159/000179602

出版商:S. Karger AG    

年代:1967

数据来源: Karger

摘要:

Une ponction biopsie rénale a été faite chez 33 malades ayant une protéinurie strictement isolée. Chez douze d’entre eux, les lésions frappent avant tout le réseau artériel. Une endartérite fibroélastique isolée des artères interlobulaires est observée dans quatre cas. Huit fois, I’atteinte est faite de dépôts fibrinoïdes et hyalins dans les artérioles juxta et pré-glomérulaires, parfois associés à une hyalinose du floculus. A ne considérer que la morphologie, il n’y a aucune difference entre ces derniers cas et ceux de sujets atteints de néphroangiosclérose. Ces faits suggèrent que les lésions artériolaires rénales ne sont pas obligatoirement la conséquence de I’élévation tensionnelle et qu’un certain pourcentage de protéinuries relèvent d’une néph

ISSN:1660-8151    

DOI:10.1159/000179568

出版商:S. Karger AG    

年代:1967

数据来源: Karger

ISSN:1660-8151    

DOI:10.1159/000179604

出版商:S. Karger AG    

年代:1967

数据来源: Karger

摘要:

An experiment was designed to compare the effects of chlorothiazide, furosemide, ethacrynic acid and MK870 on cortico-medullary gradients of sodium and urea in the rat kidney. The sodium concentration gradient did not fall significantly after treatment with chlorothiazide and there was no increase in the water content of the papillary tip. Furosemide, ethacrynic acid and MK870 reduced the sodium concentration but not the sodium content of the outer medulla and papillary tip. This effect was shown to be due to a marked increase in the water content of these tissues. The results are not consistent with the theory that furosemide and ethacrynic acid block sodium reabsorption in the ascending limb of the loop of Henle of the rat. Furosemide and ethacrynic acid had similar effects on the gradients, yet, of the two, only furosemide produced a significant natriuresis in the rat. All the diuretics produced a marked depletion of medullary urea.

ISSN:1660-8151    

DOI:10.1159/000179569

出版商:S. Karger AG    

年代:1967

数据来源: Karger

ISSN:1660-8151    

DOI:10.1159/000179605

出版商:S. Karger AG    

年代:1967

数据来源: Karger

摘要:

The effect on the intrarenal vascular architecture of the graft-reaction when modified by administration of Imuran has been examined by a combination of stereomicro-angiographic and histologic methods on 14 canine renal allografts. When removed 13–140 days after the operation the grafts displayed varying micro-angiographic and histologic pictures, from largely normal morphology to a marked graft reaction with subsequent scarring and organisation or resorption. In specimens with little or no histological alterations the micro-angiographic pattern was normal, while the kidneys displaying rejection evidenced pathologic arteriovenous communications. The results suggest that because of the variability of the graft-reaction the renal grafts associated with the administration of Imuran can develop pathologic arteriovenous anastomoses with the same appearance as those seen in allografts when no Imuran has been given. On the other hand, the drug would seem to be able to retard this vascular damage, or even induce healing of these arteriovenous communication

ISSN:1660-8151    

DOI:10.1159/000179570

出版商:S. Karger AG    

年代:1967

数据来源: Karger

ISSN:1660-8151    

DOI:10.1159/000179606

出版商:S. Karger AG    

年代:1967

数据来源: Karger

ISSN:1660-8151    

DOI:10.1159/000179571

出版商:S. Karger AG    

年代:1967

数据来源: Karger

ISSN:1660-8151    

DOI:10.1159/000179607

出版商:S. Karger AG    

年代:1967

数据来源: Karger