ISSN:1660-8151    

DOI:10.1159/000185561

出版商:S. Karger AG    

年代:1989

数据来源: Karger

ISSN:1660-8151    

DOI:10.1159/000185562

出版商:S. Karger AG    

年代:1989

数据来源: Karger

摘要:

β2-Microglobulin (β2M) plasma levels and levels of a second low-molecular-weight protein (myoglobin) were studied during a 2- to 4-hour sham dialysis period (no dialysate flow, no weight loss) and during a 4- to 5-hour hemodialysis (HD) with a Cuprophan® capillary dialyzer. While no rise of the β2M or myoglobin levels occurred during sham dialysis, a rise of 22.1 ± (SD)8.5% (β2M) or 19.9 ± 12.1% (myoglobin) was seen during regular HD. The increases of both molecules showed a significant correlation (r = 0.44; p < 0.03). Both rises could not be completely abolished using correction factors for hemoconcentration. The rises occurred irrespectively of the dialysate buffer. The results suggest that neither the Cuprophan membrane nor the extracorporeal circuit were responsible for the rise of both molecules during HD. It seems more likely that changes of the extracellular volume and extra- to intracellular water shifts are involved and account for the majority of the rise. However, the possibility of minor increase in the extracellular mass of β2M or myoglobin cannot be excluded com

ISSN:1660-8151    

DOI:10.1159/000185232

出版商:S. Karger AG    

年代:1989

数据来源: Karger

ISSN:1660-8151    

DOI:10.1159/000185564

出版商:S. Karger AG    

年代:1989

数据来源: Karger

摘要:

We measured serum urate in 3,258 Japanese outpatients. Five of them had persistent hypouricemia. Three also had microhematuria. Four of the five patients were proven to have renal uricosuria with hypouricemia, but otherwise normal tubular function. When tested with both pyrazinamide and benzbromarone, 1 patient had a presecretory reabsorption defect, 2 had postabsorption defects, and 1 an enhanced renal tubular secretion of urate. These results suggest that persistent hypouricemia in outpatients is of very low incidence, is usually caused by an isolated metabolic error of urate transport, and is not related to drug ingestion or systemic disease.

ISSN:1660-8151    

DOI:10.1159/000185233

出版商:S. Karger AG    

年代:1989

数据来源: Karger

ISSN:1660-8151    

DOI:10.1159/000185565

出版商:S. Karger AG    

年代:1989

数据来源: Karger

摘要:

Renal biopsies from 12 patients with idiopathic membranous glomerulonephritis (IMGN) were investigated by immunofluorescence microscopy for the localization of C4d and C4-binding protein (C4bp). Although C1q and C4 deposits were found in only 2 of 12 cases (16%), C4d and C4bp deposits were identified in 11 cases (92%) in close association with IgG deposits in the glomeruli. The results suggest that complement activation through the classical pathway usually occurs in IMGN. The detection of C4d and C4bp in the glomeruli appears to be a sensitive indicator of the classical pathway activation in IMGN.

ISSN:1660-8151    

DOI:10.1159/000185234

出版商:S. Karger AG    

年代:1989

数据来源: Karger

ISSN:1660-8151    

DOI:10.1159/000185566

出版商:S. Karger AG    

年代:1989

数据来源: Karger

摘要:

Fibrinopeptide A (FPA), a sensitive index of in vivo thrombin activity, β-thromboglobulin (βTG) and platelet factor 4 (PF4), specific markers of platelet intravascular activation, have been measured in plasma by radioimmunoassays in 23 patients with nephrotic syndrome and in 32 normal subjects. FPA concentration was 2.40 ± 1.42 ng/ml (mean ± SD) in nephrotic patients and 1.16 ± 0.58 ng/ml in normal controls (p < 0.001); βTG concentration was 57.9 ± 33.2 ng/ml in nephrotic patients and 25.7 ± 7.4 ng/ml in controls (p < 0.001); PF4 level was not different from controls. These data indicate in vivo blood hypercoagulability and platelet hyperfunction in nephrotic syndrome. Moreover, we have documented a slow in vitro FPA generation pattern (ΔFPA): 0.97 ± 0.51 ng/ml/l0 min; this suggests that thrombin activity is predominan

ISSN:1660-8151    

DOI:10.1159/000185236

出版商:S. Karger AG    

年代:1989

数据来源: Karger

ISSN:1660-8151    

DOI:10.1159/000185567

出版商:S. Karger AG    

年代:1989

数据来源: Karger