ISSN:1660-8151    

DOI:10.1159/000180760

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

Plasma levels of testosterone-like substances (TLS) were depressed in seven patients with chronic renal failure. Intramuscular testosterone (as Sustanon 250® once a week) elevated plasma TLS levels to above normal throughout the week with an initial high peak. Sublingual testosterone produced a high but brief peak in TLS. Results were similar in renal failure patients and normal controls. A controlled trial of weekly Sustanon 250 in 24 regular dialysis patients produced a significant increase in haemoglobin from 6.8 to 8.2 g/dl. Side effects were mainly mild and acceptable but one patient developed priapism and another a large haematoma. The discriminate use of androgens is recommended for anaemic male patients on regular haemodialysis

ISSN:1660-8151    

DOI:10.1159/000180761

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

In patients with renovascular hypertension, a significant decrease in glomerular filtration rate (GFR) and in renal plasma flow (RPF) in the stenotic kidney was accompanied by a significant homolateral decrease in extraction of PAH (EPAH) and in net tubular reabsorption of sodium (RNa)· There was a highly significant correlation between differences in RNa and differences in either GFR or RPF, while no correlation between differences in RNa and in Epah was noted. It is suggested that the nature of the relationship between GFR and RNa is essentially the same in unilateral renal artery stenosis in man, as in acute constriction of the renal artery or the aorta in the experimental animal

ISSN:1660-8151    

DOI:10.1159/000180762

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

Hypercalcemia was induced in 5/6 nephrectomized rats fed a low calcium diet by administering pharmacologic doses of vitamin D. The degree of hypercalcemia was greater in uremic rats than in sham-operated rats both of which were given vitamin D. Bone resorption was marked in both groups but differed in distribution. Increased osteoclasis in uremic rats was limited to diaphyseal cortical bone while metaphyseal trabeculae were relatively unaffected compared to sham-operated rats administered vitamin D. Ultrastructurally thyroid C cells were degranulated and in an active stage in both groups of rats receiving vitamin D. Urinary calcium excretion was greater in sham-operated rats given vitamin D than in uremic rats. The greater renal retention of calcium in uremic rats given vitamin D was felt to contribute to the development of hypercalcemia. These studies suggest that although trabecular bone was resistant to pharmacologic levels of vitamin D in renal failure, hypercalcemia developed due to selective resorption of cortical bone and impairment of renal calcium excretion.

ISSN:1660-8151    

DOI:10.1159/000180763

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

The purpose of this study was to examine the effect of hypotonic saline diuresis on two patients with cystinosis, trying to localize the site of renal sodium loss. At the same time, we have performed the same hypotonic saline infusion under hydrochlorothiazide administration. Results seem to prove the proximal tubular localization of the salt-wasting syndrome in cystinotic patients. On the other hand, these results suggest that hydrochlorothiazide effect can be related to the hypovolemia due to the distal tubular action of hydrochlorothiazide that could inhibit the ‘third’ natriuretic factor, thus increasing the proximal tubular sodium reabsorpt

ISSN:1660-8151    

DOI:10.1159/000180764

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

A new immunochemical procedure was introduced to estimate the nephritogenic activity of collagenase and pronase digests of various rat organs. A glycoprotein isolated from collagenase digests of various rat organs showed the nephritogenic activity as well as the antigenic activity that induces nephrotoxic antibody, which were nearly identical to those of a glycoprotein isolated from trypsin digests of the rat organ concerned. A glycoprotein isolated from pronase digests of various rat organs was proved to have no antigenic activity that induces nephrotoxic antibody, but the existence of nephritogenic activity was proved in this glycoprotein. These results were supported firmly by the assay experiments for nephritogenicity. Ouchterlony gel diffusion test and the assay experiments demonstrated the existence of a common nephritogenic substance among the glycoproteins isolated from trypsin, collagenase and pronase digests of rat organs.

ISSN:1660-8151    

DOI:10.1159/000180765

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

Proteinuria was studied in ten renal allograft recipients; it was defined as: (a) glomerular – characterized by predominant albumin excretion; (b) tubular – significant excretion of both albumin and low molecular weight (LMW) proteins; and (c) glomerulo-tubular or mixed type, a combination of the two. LMW protein and albumin were quantitated by polyacrylamide gel electrophoresis with sodium dodecyl sulfate. In the immediate posttransplant period, LMW protein and albumin excretion, expressed as a percentage of creatinine clearance, were high, revealing a mixed pattern, and excretion of both protein classes was higher than during both acute tubular necrosis and acute rejection crisis. Tubular proteinuria was observed in acute tubular necrosis; a glomerulo-tubular or mixed pattern of protein excretion in acute rejection cri

ISSN:1660-8151    

DOI:10.1159/000180766

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

Parathyroid hormone (PTH) and catecholamines (CA) increased cAMP levels in isolated tubules of rat renal cortex. A rise in cAMP could be detected 10 sec after the addition of agonists, and it reached the peak in 30–60 sec and then decreased despite the presence of active agonists. Direct relationships exist between theophylline concentrations and cAMP levels in response to agonists. Three- to fivefold rises in cAMP levels were observed with a maximal dose of PTH compared with that of CA, and there was no additive effect. Both PTH and CA stimulated renal gluconeogenesis; when added together with each maximal dose, no additive effect was observed. These results suggest the important role of phosphodiesterase to control tubular cAMP in response to hormonal stimuli, and there is a tubule cell group responding to both PTH and C

ISSN:1660-8151    

DOI:10.1159/000180767

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

The prevalence of pancreatic disease was determined in 21 autopsied uremic patients who had died during the course of maintenance hemodialysis, as compared with 60 autopsied patients without kidney or pancreatic disease. Histologic criteria of pancreatic disease included. (1) duct ectasia; (2) periductal fibrosis; (3) ductular proliferation; (4) acinar ductalar metaplasia, and (5) interstitial inflammation or fibrosis. Significant pancreatic disease was present in 56% of the uremic patients and only 11.8% of the controls (p < 0.01). Two uremic patients had abscesses in the tail of the pancreas. The clinical significance of the high prevalence of pancreatic pathologic alterations in uremia remains to be assessed.

ISSN:1660-8151    

DOI:10.1159/000180768

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

We have in vitro and in vivo tested the new Gambro Lundia Mini-Minor pediatric dialyzer with the 17 µm membrane. By utilizing blood tubing sets of different volumes in conjunction with the Lundia Mini-Minor we feel that this dialyzer is well suited to use in pediatric patients weighing less than 16–23 kg. During the last 4 years, with the development of improved equipment and techniques, it has become increasingly easier to hemodialyze children and infants with end-stage and acute renal failure [1,2]. We have previously reported our experience with hemodialyzers designed especially for children and babies [1–5,13,14]. This report concerns our experience with a new disposable pediatric hemodialyzer, the Lundia Mini-Minor, which has been designed for the smaller pediatric patient weighing less than 1

ISSN:1660-8151    

DOI:10.1159/000180769

出版商:S. Karger AG    

年代:1977

数据来源: Karger