摘要:

A suspension of red blood cells labelled with the fluorescent dye Thioflavine S was injected intravenously in hydropenic rats. The blood flow through the cortical and juxtamedullary glomeruli was compared by counting the number of fluorescent cells present per unit volume of glomerular tissue a short time after the injection. It was found that the number of fluorescent cells was significantly less in the juxta-medullary than in the cortical glomeruli and this is interpreted as indicating a diminished blood flow through the juxta-medullary glomeruli and thus through the vasa recta.

ISSN:1660-8151    

DOI:10.1159/000179612

出版商:S. Karger AG    

年代:1968

数据来源: Karger

摘要:

The presence of filtered hemoglobin in Bowman’s space of in vivo fixed glomeruli was ascertained by microspectrophotometry and special staining of sections for light microscopy. By electron microscopy, hemoglobin appeared as a finely granular material in the lumens of glomerular capillaries and in Bowman’s space. Filtration of hemoglobin was usually unassociated with morphologic alterations in endothelial or epithelial cells. During filtration, the hemoglobin molecules seemed to traverse the endothelium across the diaphragm closing the fenestrae. Following transport through the basement membrane, the molecules gained access to Bowman’s space by passing through the filtration slit membranes between the foot processes. Uptake of hemoglobin by glomerular epithelial cells was minimal or lacking. Fusion of foot processes was noted occasionally at late intervals after the induction of hemoglobinuria; it appeared to reflect focal damage of epithelial cells, rather than a general, immediate reaction of epithelial cells to filtration of the concentrated solution of hemoprotein mole

ISSN:1660-8151    

DOI:10.1159/000179613

出版商:S. Karger AG    

年代:1968

数据来源: Karger

摘要:

A patient with intrarenal arteriovenous fistula and the development of severe diastolic hypertension following percutaneous renal biopsy is presented in detail. The fistula was discovered by auscultation of the flank area and demonstrated by arteriography. Studies for renal underperfusion were unconclusive. The hypertension was cured by nephrectomy. The possibility of an arteriovenous fistula should always be suspected when a post-renal biopsy patient develops unexplained hypertension.

ISSN:1660-8151    

DOI:10.1159/000179614

出版商:S. Karger AG    

年代:1968

数据来源: Karger

摘要:

La polynévrite de 10 malades atteints d’urémie chronique terminale a été étudiée avant et après transplantation rénale. L’évolution des signes d’atteinte du neurone périphérique après restauration de la fonction rénale par transplantation d’un rein fut, dans ces dix observations, favorable. Les signes cliniques, les paresthésies, les troubles moteurs s’améliorèrent dès les premières semaines qui suivirent la transplantation pour disparaître apparemment de façon complète après un à deux ans d’évolution dans 3 de ces 10 cas. L’amélioration des signes électrologiques fut plus lente, dissociée, incomplète, la régression presque toujours totale des troubles de transmission de l’influx nerveux contrastant avec la persistance habituelle d’altérations du tracé électromyographique de la contraction volontaire. La mesure répétée de la vitesse de conduction nerveuse nous a paru constituer actuellement l’exploration la mieux adaptée à la surveillance neurologique de ces malades. L’intensité des paralysies, le degré de ralentissement de la vitesse de conduction nerveuse semblent permettre d’évaluer les chances de récupération du déficit neurologique après transplantation rénale. L’étude du tracé de contraction volontaire fournit des informations susceptibles d’éclairer le mécanisme de l’amélioration de ces polynévrites. Elle montre chez nos 10 malades, la dénervation définitive d’un certain nombre d’unités motrices. L’observation de ces altérations du tracé chez des malades ayant apparemment une récupération motrice compléte, suggère que la réparation ne porte que sur les fibres qui étaient encore partiellement fonctionnelles au moment de la transplantation. Sur deux malades on nota des images compatibles avec l’existence d’une atteinte proprement musculaire pour laquelle il est formulé l’hypothèse que la corticothérapie a pu jouer un rôle. Enfin, les ca

ISSN:1660-8151    

DOI:10.1159/000179615

出版商:S. Karger AG    

年代:1968

数据来源: Karger

摘要:

The normal rates of glucose excretion in man and dog were measured, and the effects of water diuresis, osmotic diuresis, and plasma glucose concentration on glucose excretion were studied by the clearance method. The possibilities of more complete glucose reabsorption and glucose secretion were examined with the stop-flow technique in dogs. In unfasted human subjects, glucose excretion rate was higher in the afternoon and evening and correlated with urine flow rate. In fasted human subjects, water loading did not alter glucose excretion; whereas, water loading of fasted trained dogs increased glucose excretion and clearance. With mannitol osmotic diuresis induced in dogs undergoing maximal water diuresis, glucose clearance was approximately proportional to the urine volume flow rate. In both human subjects and dogs, glucose clearance was not significantly altered by moderate variation in plasma glucose levels. Stop-flow experiments on anesthetized dogs demonstrated that under these conditions glucose is added to the urinary fluid stopped in renal pelvis or collecting duct; however, this phenomenon is probably not a significant determinant of glucose excretion during normal free-flow. Glucose reabsorption by the proximal tubule was not as complete during stop-flow as during free-flow and indicates that failure of glucose to be completely reabsorbed is not caused by insufficient time for reabsorption. The findings are consistent with the concept that glucose excretion is normally determined by the volume flow rate from the proximal tubule and by the glucose concentration gradient finally effected across the epithelium.

ISSN:1660-8151    

DOI:10.1159/000179616

出版商:S. Karger AG    

年代:1968

数据来源: Karger

ISSN:1660-8151    

DOI:10.1159/000179617

出版商:S. Karger AG    

年代:1968

数据来源: Karger

ISSN:1660-8151    

DOI:10.1159/000179618

出版商:S. Karger AG    

年代:1968

数据来源: Karger