摘要:

A cross-infusion model including two dogs was used. At intervals 20 ml of blood from the iliac vein of one dog (donor), was injected during 60 sec into the iliac artery in which flow was measured electromagnetically in another dog (recipient). 1 min after missile trauma to the hind leg of the donor, the withdrawn venous blood possessed strong dilator property, manifesting itself by a transient, significant increase of blood flow in the registered artery of the recipient. This dilator property of venous blood from the traumatized region was, however, only apparent following wounding by missiles of high velocity.

ISSN:0014-312X    

DOI:10.1159/000127805

出版商:S. Karger AG    

年代:1975

数据来源: Karger

摘要:

Bile secretion and blood flow in the portal vein and the hepatic artery were determined in cholecystectomized anesthetized dogs before and during continuous infusion of varying doses of secretin. Secretin increases bile volume without alteration of bile acid output. Hepatic arterial flow was not altered by any dose. However, high doses of secretin increased portal venous blood flow significantly. It is concluded that secretin action on liver blood flow mirrors mainly superior mesenteric arterial vasodilation and seems to be a rather pharmacologic than a physiologic response. Bile secretion is not influenced by changes of hepatic blood flow in the physiologic range.

ISSN:0014-312X    

DOI:10.1159/000127806

出版商:S. Karger AG    

年代:1975

数据来源: Karger

摘要:

Heterotopic transplantation of a duct-ligated canine pancreas was performed in 20 previously pancreatectomized, non-related recipient dogs. A technical procedure was elaborated for this grafting. It was found that early, fatal postoperative bleeding in the recipient could be avoided when the interval between pancreatectomy and transplantation was reduced from 7 to 2–4 days. The early endocrine function was studied in 15 surviving animals by determination of blood glucose and serum insulin during fasting and during glucose load. 24 h after transplantation the blood glucose values were normal and 4–8 days after transplantation the glucose tolerance was within normal limits. The serum insulin was on a supranormal level, also during glucose load. The early endocrine capacity of the transplanted duct-ligated pancreas after transplantation was found to be satisfactory, restoring the blood glucose in the pancreatectomized recipients to normal lev

ISSN:0014-312X    

DOI:10.1159/000127807

出版商:S. Karger AG    

年代:1975

数据来源: Karger

摘要:

In an experimental model adapted to avoid severe systemic lesions, renal cortical necrosis was frequently induced in rabbits by repeated administration of endotoxin. The experimental model involves perfusion of the kidney in situ with endotoxin. Another dose of endotoxin was given intravenously 24–28 h before or after the perfusion. A significant effect of the perfusion or the endotoxin administered first was reflected by the pronounced unilateral morphological alterations appearing after the second administration of endotoxin. Some of the kidneys with cortical necrosis had band- or ring-shaped areas of preserved juxtamedullary tissue. Heavy infiltration of leukocytes at the borders of these areas called for commentation of the histological picture of infarcts, incorrectly described even in most modern textbook

ISSN:0014-312X    

DOI:10.1159/000127808

出版商:S. Karger AG    

年代:1975

数据来源: Karger

摘要:

Prolongation of survival time of heart transplants in inbred rats following intravenous injection of donor strain blood according to various time-dose schedules is described. The immunological status of long-term survivors shows detectable antidonor antibodies, normal graft-versus-host reactions and rejection of skin grafts in the usual time. Lymphocytotoxic activity is well related to the survival time of the heart in those rats which respond to the treatment.

ISSN:0014-312X    

DOI:10.1159/000127809

出版商:S. Karger AG    

年代:1975

数据来源: Karger

摘要:

Fifteen men, 30–40 years old, who had received one dose of vaccine against tetanus, were given a booster dose 8–13 years later. Their serum content of tetanus antitoxin was determined (1) before the booster dose, (2) 3–4 days and (3) 8 days after the booster dose. A control group of ten men with 2–3 earlier vaccine injections was treated in the same way. All the men in the first group had an antitoxin content of 0.01 IU/ml or more, 8 days after the booster dose, while the comparative titres increased to more than 1 IU/ml in the control group. The advantage of a complete basic immunization is obvious, but the investigation shows that, even after one injection, the titre after a booster dose increased to a generally accepted protectiv

ISSN:0014-312X    

DOI:10.1159/000127810

出版商:S. Karger AG    

年代:1975

数据来源: Karger

摘要:

Changes of total liver blood flow (TLBF), portal venous and hepatic arterial flows have been investigated using a hemorrhagic model in dogs. The dogs were bled stepwise from normal blood pressure to a pressure of 50–60 mm Hg. TLBF was measured by the xenon clearance method. Hepatic arterial blood flow was measured by electromagnetic flowmeter. Portal venous flow was calculated by subtracting hepatic arterial blood flow from TLBF. Other parameters studied during the experiment were systemic arterial blood pressure and portal venous pressure. Under normotensive conditions TLBF in mean was registered as 127 ml/min × 100 g liver tissue (25 ml/min × kg body weight). The relation between the flow value in portal vein and hepatic artery was on average 2.3:1. The study shows that there was a pronounced decrease of TLBF flow during hemorrhage. Portal venous flow decreased almost parallel to TLBF, while hepatic arterial flow decreased to a lesser extent which means that there was autoregulation in this flow bed. Hepatic arterial flow successively constituted a larger part of TLBF, during hemorrhage sometimes 65% compared to the normal value of about 30%. During the study there was an increase of vascular resistance in the portal venous system and decreased resistance in the hepatic arterial

ISSN:0014-312X    

DOI:10.1159/000127811

出版商:S. Karger AG    

年代:1975

数据来源: Karger

摘要:

Ischaemia in the entire left ventricular wall was induced in dogs by installment of ameroid constrictors on the left anterior descending (LAD) and left circumflex (LC) branches of the left coronary artery (series A). Ischaemia in the anterior left ventricular wall was induced by installment of an ameroid constrictor on LAD and ligation of all (series B) or part of (series C) the subepicardial intercoronary anastomoses between LC and LAD. The effect of the operation was studied by electrocardiography and coronary angiography and, post mortem by radiography of the coronary arteries and histopathology of myocardium and coronary arteries. The high early mortality rate in series A and B precludes the further use of these procedures. In series C the mortality rate was low and in half of the cases lasting myocardial ischaemia of the anterior wall of the left ventricle was produced. The development of a small myocardial infarction was inevitable, but it was healed by the time the sought after state of stable myocardial ischaemia was reached.

ISSN:0014-312X    

DOI:10.1159/000127812

出版商:S. Karger AG    

年代:1975

数据来源: Karger

摘要:

The behaviour of eight duct-ligated canine pancreata was studied during 23 hours of continuous, hypothermic perfusion, with an albumin electrolyte solution. The organs developed a considerable oedema during perfusion. This did not seem to influence on the vascular resistance of the organs. A continuous insulin release, a moderate increase in LDH concentration and only small changes in the electrolyte concentrations were observed in the perfusate, indicating only a moderate degree of cellular damage.

ISSN:0014-312X    

DOI:10.1159/000127813

出版商:S. Karger AG    

年代:1975

数据来源: Karger

摘要:

A vasocystostomy in the rat is described, a new technique simplifying the common methods of spermatozoa output measuring. In two series of different rat strains a mean output of 21.1 × 106 and 29.0 × 106 spermatozoa per 24 h were found. Perspectives of the new method are discusse

ISSN:0014-312X    

DOI:10.1159/000127814

出版商:S. Karger AG    

年代:1975

数据来源: Karger