摘要:

Nipple valve ileostomies with and without a preformed pouch as well as conventional ileostomies were compared in dogs. In both groups with a nipple valve, a 150–200 ml reservoir developed. It was about 30 cm long when not preformed by an operation. Equal dilatation of the proximal bowel was observed in both groups with a nipple valve and both these groups had a substantial loss of weight which seemed to correspond with mucosal changes indicating malabsorption. For continent ileostomy function in dogs, the preformed pouch thus seems unnecessar

ISSN:0014-312X    

DOI:10.1159/000127986

出版商:S. Karger AG    

年代:1978

数据来源: Karger

ISSN:0014-312X    

DOI:10.1159/000128040

出版商:S. Karger AG    

年代:1978

数据来源: Karger

ISSN:0014-312X    

DOI:10.1159/000128041

出版商:S. Karger AG    

年代:1978

数据来源: Karger

摘要:

In human renal venous strips from normotensive and hypertensive patients, adrenergic- and nonadrenergic-induced contractions were elicited. The maximal amplitude of contractions remained unchanged whatever the mode of activation. However, in the hypertensive group the forces generated reached only about 20% of those in the normotensive group. Furthermore, preparations from hypertensive patients showed a reduced sensitivity for noradrenaline: the ED50 was shifted from 0.13 ± 0.03 to 0.66 ± 0.19 ug/ml (p < 0.01). This reduced sensitivity is discussed in connection with the pathogenesis of hypertensio

ISSN:0014-312X    

DOI:10.1159/000127987

出版商:S. Karger AG    

年代:1978

数据来源: Karger

摘要:

The effects of pressure-induced ischemia on energy metabolism, measured as ATP and glucose content, is studied in hamster cheek pouch. Metabolic deterioration during ischemia is studied and after 2 h the glucose content was significantly reduced but not the ATP content, which was significantly reduced after 4 h of ischemia. Restoration of glucose levels in the cheek pouch tissue was achieved within 30 min of recirculation after release of pressure. The cellular energy metabolism is unable after 4 h of ischemia to restore ATP levels in the tissue during the 120-min of postischemic observation time. There is a difference in ability to resume normal energy metabolism after 2 and 4 h of pressure-induced ischemia.

ISSN:0014-312X    

DOI:10.1159/000127988

出版商:S. Karger AG    

年代:1978

数据来源: Karger

摘要:

Skeletal muscle blood flow and transport function were investigated in 25 patients operated on for a knee injury in a bloodless field. With a double-isotope-clearance technique, measurements were carried out in the operated leg immediately after re-establishment of blood flow, and 1–2 days postoperatively in both the operated and the non-operated leg. A significant increase in blood flow and transport function was registered immediately after release of the tourniquet. The initial maximal hyperemic flow and transport responses were inversely related to the duration of the occlusion. The peak of the blood flow response was more marked and somewhat earlier in the patients with a short duration of occlusion (<60 min) than in those with longer occlusions. 9 of 16 operated legs showed a maximal transport function 1–2 days postoperatively. Peripheral vascular resistance decreased after re-establishment of blood flow. The blood flow in the non-operated leg showed no changes after release of the tourniquet in the operated

ISSN:0014-312X    

DOI:10.1159/000127989

出版商:S. Karger AG    

年代:1978

数据来源: Karger

ISSN:0014-312X    

DOI:10.1159/000315652

出版商:S. Karger AG    

年代:1978

数据来源: Karger

摘要:

Diazoxide, a known insulin inhibitor, inhibits the pancreatic exocrine response to secretin in unanesthetized rats and does not modify the CCK-PZ-stimulated secretion. These results suggest that insulin may have a role on the stimulation of exocrine pancreas through secretin.

ISSN:0014-312X    

DOI:10.1159/000127990

出版商:S. Karger AG    

年代:1978

数据来源: Karger

摘要:

Xenogenic antilymphocyte globulin (ALG) given as a rapid intravenous injection into dogs caused a significant decrease in arterial blood pressure and oxygenation as well as an increase in portal pressure. At the same time, there was an almost complete elimination of lymphocytes and an extensive but almost completely reversible thrombocytopenia. Lymphocytopenia induced by a previous injection of ALG was found to eliminate completely the circulatory response to a second injection of ALG in spite of the fact that an extensive thrombocytopenia was induced. Extensive thrombocytopenia induced by injection of an antiplatelet globulin was also found to prevent completely the hemodynamic effects of ALG although as many lymphocytes were eliminated as in the intact dogs. Thus both platelets and lymphocytes are necessary to trigger the circulatory response induced by ALG.

ISSN:0014-312X    

DOI:10.1159/000127991

出版商:S. Karger AG    

年代:1978

数据来源: Karger

摘要:

Endotoxin shock (ES) was induced in Labrador retriever dogs by infusion of a lethal dose of Escherichia coli endotoxin. Spontaneous plasma kallikrein activity and prekallikrein levels were determined during subsequent stages of the shock both by an esterolytic assay (BAEe) and a new amidolytic assay utilizing a chromogenic tripeptide derivative (Chromozym PK, Pentapharm AG, Basel Switzerland). During the late stages of shock characterized by a substantial decline of blood pressure, plasma prekallikrein levels determined by the amidolytic assay were considerably reduced. In this phase of the shock both the esterolytic and the amidolytic assays revealed a significant elevation of spontaneous activity. Plasma prekallikrein determined by the esterolytic assay was found to be elevated vs. control values for the whole duration of ES. The findings made seem to associate activation of the plasma kallikrein-kinin system to the circulatory collapse of endotoxin shock in dogs.

ISSN:0014-312X    

DOI:10.1159/000127992

出版商:S. Karger AG    

年代:1978

数据来源: Karger