ISSN:0014-312X    

DOI:10.1159/000127905

出版商:S. Karger AG    

年代:1976

数据来源: Karger

摘要:

50 consecutive male patients with a proven duodenal ulcer disease without pyloric stenosis were electively treated with a proximal selective vagotomy. They were randomized in a group with and a group without pyloroplasty. Up to now (1–3 years follow-up) no recurrences were found, and only two patients have major complaints (Visich grading 3). There are no differences between the two groups, as judged by the clinical result, the pentagastrin test, the Hollander test (2-DODG stimulation), and the gastrin analysis. Pyloroplasty therefore is not needed. Although the vagotomy which completely preserves antral motility is mostly incomplete in the Hollander test, it is sufficient as judged by the clinical results and the acid respons

ISSN:0014-312X    

DOI:10.1159/000127843

出版商:S. Karger AG    

年代:1976

数据来源: Karger

摘要:

Electrical and mechanical activity were recorded from totally isolated whole porcine stomachs perfused with homologous blood. Stagnant, complete ischemia was then produced by closing the gastric artery and vein for various periods of time up to 3 h. After a given period of ischemia, blood was recirculated for 10 min and then pentagastrin was injected into the gastric artery. The vagus nerve was also electrically stimulated at various stages of anoxia and recirculation. After up to 90 min of ischemia, stomachs were able to demonstrate electrical control activity of low frequency after 10 min of blood recirculation. After injection of pentagastrin, electrical control activity rapidly became normal. When ischemia lasted 120 min or longer, recirculation of blood did not induce reappearance of electrical control activity, but pentagastrin injection produced a normal response. After ischemia of 240 min duration or longer, recirculation and pentagastrin had no effect. In previously ischemic stomachs the response to vagal stimulation occurred only in the stomachs responding to pentagastrin.

ISSN:0014-312X    

DOI:10.1159/000127844

出版商:S. Karger AG    

年代:1976

数据来源: Karger

ISSN:0014-312X    

DOI:10.1159/000315629

出版商:S. Karger AG    

年代:1976

数据来源: Karger

摘要:

Myoelectrical activity of the gut has been studied in the postoperative period on 54 patients who underwent cholecystectomy. They have been divided into one control group and four other groups which were treated with pentagastrin, cholecystokinin, prostigmine or coherin (a posterior pituitary extract). In all patients, bursts of spikes were recorded during the early postoperative period. However, the slow waves were strongly disturbed at this time. Pentagastrin, CCK-PZ and prostigmine had no effect on the slow waves, while they increased the frequency of the spikes. These substances did not reduce the duration of the ‘physiological’ ileus. On the contrary, coherin was found to improve the regularity of the slow waves and to reduce the duration of the ‘physiological

ISSN:0014-312X    

DOI:10.1159/000127845

出版商:S. Karger AG    

年代:1976

数据来源: Karger

摘要:

Gastric ulcer was induced in rats by the application of acetic acid to the anterior wall of the stomach. Leakage of circulating albumin into the gastric wall was estimated by intravenous injection of radioactive albumin and determination of the radioactivity in different samples of the stomach wall. The protein leakage was found to be markedly increased in the anterior wall of the stomach, the increase being most pronounced close to the ulcer. The leakage remained fairly constant during the first 10 h of the experiment. The protein content of the posterior wall was about the same as in animals on which a sham operation had been performed. The protein leakage was associated with considerable oedema formation. The protein leakage indicates that inflammatory mediators are released in a wide area around the ulcer. The present experimental model offers an opportunity to find out which mediators are involved in the lesion.

ISSN:0014-312X    

DOI:10.1159/000127846

出版商:S. Karger AG    

年代:1976

数据来源: Karger

ISSN:0014-312X    

DOI:10.1159/000315630

出版商:S. Karger AG    

年代:1976

数据来源: Karger

摘要:

Induced thrombocytopenia has been found to decrease metastasis formation after intravenous tumour cell injection which emphasizes the importance of platelets in metastasis formation. Using a syngeneic 20-methylcholanthrene-induced fibrosarcoma in rats, the effect of platelet reduction was investigated in combination with trauma and infusion of dextran 1000. It was found that platelets were important for the increased formation of metastases after trauma but not for the increased formation of metastases after infusion of dextran 1000. Thus, trauma and dextran 1000 stimulate metastasis formation by different mechanisms. Possible explanations are discussed.

ISSN:0014-312X    

DOI:10.1159/000127847

出版商:S. Karger AG    

年代:1976

数据来源: Karger

摘要:

A method involving isotope labelling of blood components and then rapid freezing of intact rats, was used for evaluation of the blood content in liver, spleen and gastrointestinal (GI) tract in cholestatic animals. For comparison also another important blood depot, i.e. the lungs, was examined. After 4 days of cholestasis the animals were hypovolemic, however, the partition of blood in the liver and GI tract was unchanged or even increased. In contrast the lung blood volume and the erythrocyte content of the spleen were markedly reduced. Three days later the animals had regained their normal blood volume, but still there was a redistribution of blood from the lungs and spleen to the liver and GI tract. We suggest that during cholestasis the depot function of the splanchnic vessels is disturbed. This might be one factor of importance for development of the hepatorenal syndrome.

ISSN:0014-312X    

DOI:10.1159/000127848

出版商:S. Karger AG    

年代:1976

数据来源: Karger

摘要:

The effect of pulverized plastic and glass-ceramic materials (methylmetacrylate, MMA), which are used as implantation materials in surgical medicine, on cell growth, DNA synthesis rate (adjudged by incorporation of 3H-thymidine into DNA), glucose consumption and lactate production (glycolytic rate) was studied in asynchronous monolayer cultures of rather fast proliferating Ehrlich ascites tumor cells and rather slowly proliferating diploid human fibroblasts. Exposure of Ehrlich ascites cells to high concentrations (2 mg/ml; 10 ml medium per culture) of ceramic or plastic material resulted in a gradual inhibition of cell growth and DNA synthesis rate. Protein synthesis, as measured by the incorporation of 3H-leucine, was somewhat less affected than DNA synthesis. Also, the glycolytic rate of Ehrlich ascites cells was slightly but significantly decreased in the presence of 2 mg/ml ceramics or MMA. Exposure of Ehrlich ascites cells to 0.2 or 0.02 mg/ml over a period of 46 h revealed none or only slight inhibitory effects on growth, DNA synthesis or glycolytic rate. On the other side, growth, DNA synthesis and glycolytic rates of human fibroblasts were nearly not affected by the presence of the same concentrations (up to 2 mg/ml, incubation period: 92 h) of pulverized ceramic or plastic material (MMA). It is suggested that this differential cellular sensitivity might be related to differences in the binding (to the cell surface) or uptake of these substances and possibly to differential intracellular lysosomal activation.

ISSN:0014-312X    

DOI:10.1159/000127849

出版商:S. Karger AG    

年代:1976

数据来源: Karger