ISSN:0014-312X    

DOI:10.1159/000127969

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

The morphological study of a canine cardiac transplantation whose survival was 7 years, without treatment for 6 years, is described. The pathological examination demonstrated a right-side heart failure due to pulmonary stenosis. A histological study revealed marks of chronical rejection induced by vascular fibrosis and perivascular infiltration of lymphocytes. This unusual kind of tolerance could be induced by donor blood transfusion at the time of transplantation.

ISSN:0014-312X    

DOI:10.1159/000127920

出版商:S. Karger AG    

年代:1977

数据来源: Karger

ISSN:0014-312X    

DOI:10.1159/000127970

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

A device for measuring the mean blood velocity (by means of a thermal equilibrium method) and the intravascular electrical impedance, which determines the mean sectional area of the vessel, have been mounted on the same probe (french catheter 7F). The validity, of the method has been confirmed in vitro and by 100 measurements carried out in dogs and compared with flow measurements by means of the cardio-green method. The correlation coefficient is found to be 0.98.

ISSN:0014-312X    

DOI:10.1159/000127921

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

Tissue hypoxia was induced in one group of dogs by clamping of the endotracheal tube and in another group by artificial ventilation with a mixture of nitrogen and air. The hypoxanthine concentration of venous and arterial plasma increased significantly during severe hypoxemia. When the hypoxemia was relieved, an increased venous-arterial hypoxanthine difference appeared indicating that the lung metabolism of hypoxanthine was slowed down during alveolar hypoxia. It is concluded that the level of plasma hypoxanthine in dogs during hypoxemia is dependent on the degree of tissue hypoxia, peripheral vasoregulation, and lung metabolism.

ISSN:0014-312X    

DOI:10.1159/000127922

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

Platelets were labelled with 51Cr, fibrinogen with 125I and erythrocytes with 59Fe. Disintegrated Pseudomonas bacteria were injected intravenously and radioactive measurements were made on whole blood, tissue biopsies and clottable fibrinogen. After the injection there was an immediate but transient increase of slCr activity in the lung concomitant with a decrease in platelet count and 51Cr activity of blood. In the liver there was a less pronounced increase of 51Cr activity. The fibrinogen concentration decreased slightly, paralleled by the 125I activity of whole blood and of clottable fibrinogen, whereas the 125I activity in the lung and liver remained fairly constant. There were no changes of 51Cr activity or 125I activity in biopsies from muscle, pancreas, small intestine, kidney or spleen. During the experiment (3 h) there were no signs of significant disseminated intravascular coagulation other than platelet aggregation. A consumption of fibrinogen related to the formation of fibrin plugs could not be detected. After injection of disintegrated Pseudomonas bacteria reversible platelet aggregates were formed and temporarily trapped in the pulmonary microcirculation. This microembolism might induce tissue damage and could be of importance for the development of septic pulmonary complications.

ISSN:0014-312X    

DOI:10.1159/000127923

出版商:S. Karger AG    

年代:1977

数据来源: Karger

ISSN:0014-312X    

DOI:10.1159/000315643

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

The plasma hypoxanthine concentrations increased during hemorrhagic hypotension in dogs. A venous-arterial hypoxanthine difference was found indicating metabolism of hypoxanthine in the lungs. A maximal hypoxanthine level was found during the hypotension, then the level decreased. This probably reflects peripheral vasoconstriction. During reinfusion of the blood, a new hypoxanthine peak was observed. The urate levels also increased during the hypotension. An arterial venous difference was found. This probably illustrates that hypoxanthine is metabolized to urate in the lungs. It is concluded that the increase of plasma hypoxanthine concentrations might reflect tissue hypoxia.

ISSN:0014-312X    

DOI:10.1159/000127924

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

A development of α-fetoprotein-producing tissues was investigated in 52 cases of human conceptuses ranging from 2 to 7 months in gestation by a fluorescent antibody technique. It is synthesized in endodermal cells of the yolk sac, hepatocytes including the cells of large bile canaliculi, and some gland epithelial cells of the stomach, while its accumulation also occurs in mesenchymal cells of the yolk sac and Kupffer cells of the liver. A mode of its localization in individual tissues was described and possible explanation on the origin of its producers was discussed

ISSN:0014-312X    

DOI:10.1159/000127925

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

Gastric mucosal erosions were produced in rats by pyloric occlusion and intraperitoneal injection of epinephrine. Gastric ulcer was induced by the application of acetic acid to the anterior wall of the stomach. The gastric lesions were photographed and examined microscopically. 5 h after pyloric occlusion alone, the gastric mucosa looked essentially normal. After pyloric occlusion and injection of epinephrine, superficial mucosal erosions were observed in the major portion of the fundus. The presence of an acute acetic acid ulcer was found to inhibit partly or completely the development of mucosal erosions usually induced by pyloric occlusion and injection of epinephrine. It is suggested that this might be due to a local release of inflammatory mediators around the ulcer.

ISSN:0014-312X    

DOI:10.1159/000127926

出版商:S. Karger AG    

年代:1977

数据来源: Karger