ISSN:0014-312X    

DOI:10.1159/000128096

出版商:S. Karger AG    

年代:1979

数据来源: Karger

摘要:

The effects of continuous intravenous perfusion of somatostatin on the incidence of ulcers and the histamine and serotonin gastric mucosal content in rats subjected to 12 h of restraint were studied. 51 sets of Sprague-Dawley male rats (102 animals) were divided at random into two groups. Those in group I were immobilized and treated with an intravenous infusion of isotonic saline solution. Animals in group II were also immobilized and given intravenous cyclic somatostatin dissolved in isotonic saline solution; the initial dose was 25 µg and a continuous infusion of 2.5 µg/kg/h was administered thereafter. A decrease in the ulcer index was observed in the rats perfused with somatostatin (p < 0.01) as well as a decrease in the histamine (p < 0.001) and serotonin (p < 0.01) gastric mucosal contents. These effects of somatostatin on restraint-induced stress ulcer in rats are probably to be explained by microcirculatory changes in the gastric mucosa determined by the vasoactive amines (histamine and serotonin). They constitute an important factor in the pathogenesis of these lesion

ISSN:0014-312X    

DOI:10.1159/000128047

出版商:S. Karger AG    

年代:1979

数据来源: Karger

摘要:

Partial devascularization of the stomach was performed in cats anesthetized with pentobarbital. The devascularization included all blood vessels along the greater curvature and two of the main branches of the left gastric artery. Gastric mucosal blood flow and cardiac output were determined by means of the microsphere distribution technique. The acid (H+) output from the 30th to the 60th min of pentagastrin stimulation was used as the ‘acid response value’. Blood flow and acid secretion were determined before and approximately 2 h after devascularization or sham operation. A marked decrease in acid secretion and mucosal blood flow of the corpus/fundus occurred after devascularization. A high degree of correlation was found between the decrease in acid secretion and the decrease in mucosal blood flow caused by the devascularization. The regression coefficient of acid secretion on mucosal blood flow did not change significantly after devascularizat

ISSN:0014-312X    

DOI:10.1159/000128048

出版商:S. Karger AG    

年代:1979

数据来源: Karger

摘要:

Intraarterially administered muscarine induced predictable and reproducible experimental acute pancreatitis with a simultaneous increase in amylase levels in blood. Muscarine also caused a transient rise followed by a lowering of blood glucose levels. The stimulated amylase secretion was dose-response related. The guinea pigs survived 2–21/2 h after muscarine administration. Atropine (3 and 5 mg/kg), an antimuscarinic agent, injected intraperitoneally 2 h prior to muscarine administration, (a) inhibited muscarine-induced amylase secretion, and (b) marginally increased the survival time of guinea pigs, but could not sustain the animals for further experimentation. The high death rate of experimental animals prevented the use of this method as a model for investigation of experimental acute pancreatiti

ISSN:0014-312X    

DOI:10.1159/000128049

出版商:S. Karger AG    

年代:1979

数据来源: Karger

ISSN:0014-312X    

DOI:10.1159/000315657

出版商:S. Karger AG    

年代:1979

数据来源: Karger

摘要:

The effect of prednisone bolus therapy on renal hemodynamics was studied in normal, autotransplanted as well as homotransplanted dog kidneys. After intravenous administration of prednisone (8 and 16 mg/kg/min) the total blood flow decreased and vascular resistance increased significantly. This effect was more pronounced if the drug was directly injected into the arteria renalis. The same changes were observed in autotransplanted and homotransplanted kidneys and in kidneys in rejection. Our results suggest that high dosage of prednisone decreases the renal blood flow and this adverse effect has to be considered in the therapy. The administration of the drug directly into the arteria renalis may have to be avoided.

ISSN:0014-312X    

DOI:10.1159/000128050

出版商:S. Karger AG    

年代:1979

数据来源: Karger

摘要:

101 human cadaver kidneys were preserved by means of hypofhermic pulsatile perfusion in the Gambro perfusion unit with human albumin as perfusate. Perfusate flow and some biochemical parameters were assessed during perfusion and correlated with renal function after transplantation. There is a good correlation between perfusate flow and recovery of physiological renal function. LDH released to the perfusate as viability test is of limited value: a direct correlation was only found between LDH activity and perfusion time, and LDH activity and ischemia time. Determination of pH and lactic acid level 1 h after beginning of perfusion is without practical value according to our experience. The quality of albumin in perfusion solution influences the immediate graft function.

ISSN:0014-312X    

DOI:10.1159/000128051

出版商:S. Karger AG    

年代:1979

数据来源: Karger

摘要:

The early metabolic disturbances in the liver following ligation of the left hepatic or the common bile duct were studied in the rabbits. In the rabbits subjected to ligation of the left hepatic bile duct, the phosphorylative activity of the liver mitochondria in the ligated lobe decreased to about 50% of controls 48 h after the ligation, while that in the nonligated lobe increased 2-fold. These rabbits continued to live. On the other hand, in the rabbits subjected to ligation of the common bile duct, the mitochondrial phosphorylative activity increased slightly at 3 h after the ligation but fell rapidly thereafter. The mitochondrial free NAD+ to NADH ratios and hepatic energy charge (ATP+1/2ADP/ ATP+ADP+AMP) markedly decreased after the ligation. Most of these rabbits did not survive over 2 days. These results indicate that the metabolic disturbances in the jaundiced liver are due to an impairment of the oxidative phosphorylation. In addition, it is suggested that the maintenance of the energy balance by enhanced mitochondrial phosphorylative activity is readily impaired in the jaundiced liver.

ISSN:0014-312X    

DOI:10.1159/000128052

出版商:S. Karger AG    

年代:1979

数据来源: Karger

摘要:

6 canine livers were perfused extracorporeally with bloodless fluorocarbon emulsion for 6 h. Perfusate was oxygenated in vitro with a mixture of oxygen and carbon dioxide. Biochemical studies were performed on the samples of perfusate taken from the arterial and venous lines of the perfusion circuit, and of the bile. Hepatic tissue was sampled prior to and following 6 h of perfusion for histological and biochemical studies. Changes, if any, found in the concentrations of various components of perfusate and bile, were considered due to the metabolic activity of the liver. Moderate changes of the liver architecture and a decrease of glycogen were found in hepatic tissue studied microscopically. Under the conditions of the present preliminary experiment, canine livers remained functional after 6 h of perfusion.

ISSN:0014-312X    

DOI:10.1159/000128053

出版商:S. Karger AG    

年代:1979

数据来源: Karger

ISSN:0014-312X    

DOI:10.1159/000128097

出版商:S. Karger AG    

年代:1979

数据来源: Karger