| 1. |
News From the American Heart Association |
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Circulation: Journal of the American Heart Association,
Volume 107,
Issue 1,
2003,
Page 1-1
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ISSN:0009-7322
出版商:OVID
年代:2003
数据来源: OVID
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| 2. |
Meetings Calendar |
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Circulation: Journal of the American Heart Association,
Volume 107,
Issue 1,
2003,
Page 2-2
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ISSN:0009-7322
出版商:OVID
年代:2003
数据来源: OVID
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| 3. |
Contemporary Management of Patent Foramen Ovale |
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Circulation: Journal of the American Heart Association,
Volume 107,
Issue 1,
2003,
Page 5-9
Bernhard Meier,
James Lock,
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ISSN:0009-7322
出版商:OVID
年代:2003
数据来源: OVID
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| 4. |
Reduction of Total Homocysteine Levels by Oral Folic Acid Fails to Improve Endothelial Function in Children With Chronic Renal FailureResponse |
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Circulation: Journal of the American Heart Association,
Volume 107,
Issue 1,
2003,
Page 6-7
K. Bennett-Richards,
M. Kattenhorn,
A. Donald,
G. Oakley,
L. Rees,
J. Deanfield,
Z. Varghese,
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ISSN:0009-7322
出版商:OVID
年代:2003
数据来源: OVID
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| 5. |
NADPH-Oxidase Might Also Act as an AntithromboticResponse |
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Circulation: Journal of the American Heart Association,
Volume 107,
Issue 1,
2003,
Page 8-8
Olaf Herkert,
Isabel Diebold,
Ralf Brandes,
Rudi Busse,
John Hess,
Agnes Görlach,
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ISSN:0009-7322
出版商:OVID
年代:2003
数据来源: OVID
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| 6. |
Could Elevated C-Reactive Protein in Patients With Obstructive Sleep Apnea Be Due to Obesity per se?Response |
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Circulation: Journal of the American Heart Association,
Volume 107,
Issue 1,
2003,
Page 9-9
A. Shamsuzzaman,
Mikolaj Winnicki,
Paola Lanfranchi,
Tomas Kara,
Robert Wolk,
Valentina Accurso,
Virend Somers,
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ISSN:0009-7322
出版商:OVID
年代:2003
数据来源: OVID
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| 7. |
Diets and Clinical Coronary EventsThe Truth Is Out There |
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Circulation: Journal of the American Heart Association,
Volume 107,
Issue 1,
2003,
Page 10-16
William Yancy,
Eric Westman,
Patricia French,
Robert Califf,
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PDF (160KB)
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ISSN:0009-7322
出版商:OVID
年代:2003
数据来源: OVID
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| 8. |
Is Percutaneous Left Atrial Appendage Transcatheter Occlusion an Alternative to Oral Anticoagulation in Patients With Atrial Fibrillation?Response |
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Circulation: Journal of the American Heart Association,
Volume 107,
Issue 1,
2003,
Page 11-12
Horst Sievert,
Thomas Trepels,
Dirk Fleschenberg,
Ulrike Krumsdorf,
Detlef Scherer,
Michael Lesh,
Toshiko Nakai,
Heyder Omran,
Antonio Bartorelli,
Paolo Della Bella,
Mark Reisman,
Carlo DiMario,
Peter Block,
Paul Kramer,
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ISSN:0009-7322
出版商:OVID
年代:2003
数据来源: OVID
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| 9. |
B-Type Natriuretic Peptide Predicts Sudden Death in Patients With Chronic Heart Failure |
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Circulation: Journal of the American Heart Association,
Volume 107,
Issue 1,
2003,
Page 13-13
Morrison Hodges,
James Bailey,
Timothy Church,
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PDF (5KB)
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ISSN:0009-7322
出版商:OVID
年代:2003
数据来源: OVID
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| 10. |
Aspirin Alters the Cardioprotective Effects of the Factor XIII Val34Leu Polymorphism |
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Circulation: Journal of the American Heart Association,
Volume 107,
Issue 1,
2003,
Page 17-20
Anetta Undas,
Wojciech Sydor,
Kathleen Brummel,
Jacek Musial,
Kenneth Mann,
Andrew Szczeklik,
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摘要:
Background—The mechanism underlying decreased risk for myocardial infarction in carriers of the Leu34 polymorphism of the factor (F) XIII A-subunit is unclear. Given that acetylation of fibrinogen by aspirin can alter its clotting properties and the presence of fibrin stimulates thrombin-mediated activation of FXIII, we have tested the hypothesis that treatment with aspirin differentially modulates the influence of the FXIII Val34Leu polymorphism on its activation in vivo.Methods and Results—The rates of the disappearance of FXIIIA chain and the appearance of its activated form (FXIIIAa) in sequential 30-second blood samples collected at the site of microvascular injury were compared in 14 healthy carriers of the Leu34 allele and 23 Val34 homozygotes both before and after a 7-day aspirin ingestion (75 mg/d), with the use of quantitative Western blotting. The presence of the Leu34 allele was associated with a significant increase in the maximum rate of FXIII activation by thrombin. Although the Leu34-positive and -negative subjects were similar with respect to aspirin-related impairment of thrombin generation, aspirin led to a more pronounced inhibition of the activation of FXIII in the Leu34 carriers as compared with the Val34 homozygotes.Conclusions—Inhibition of FXIII activation by aspirin is enhanced in the Leu34 carriers in vivo, suggesting that these subjects might benefit more than the Leu34-negative subjects from the reduction in risk for myocardial infarction with low-dose aspirin.
ISSN:0009-7322
出版商:OVID
年代:2003
数据来源: OVID
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