ISSN:0926-9959    

DOI:10.1111/j.1468-3083.1995.tb00274.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY

摘要:

AbstractA case of dirofilariasis is presented. The disease showed in our case subcutaneous location and was identified 9 years after the initial admittance of the patient. The mass was finally removed surgically.

ISSN:0926-9959    

DOI:10.1111/j.1468-3083.1995.tb00275.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY

摘要:

AbstractAim/ObjectiveTo prove the effectiveness of cryotherapy in the treatment of leishmaniasis cutis in a large group of patients.SubjectsTwo hundred and sixty‐six lesions of 227 patients with leishmaniasis cutis.MethodsCryotherapy with a double freeze‐thaw cycle by a CS‐76 apparatus and liquid nitrogen.ResultsAll lesions responded well with cosmetically acceptable scars. The recurrance rate was only 4%.ConclusionCryotherapy is an effective method of treatment of leishmaniasis

ISSN:0926-9959    

DOI:10.1111/j.1468-3083.1995.tb00276.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY

摘要:

AbstractAimAn immunohistochemical study was undertaken to look at immune reaction toMalassezia ovalisin seborrheic dermatitis.BackgroundThe role ofM. ovalisin seborrheic dermatitis remains a matter of controversy despite some therapeutic evidence with the use of antifungals, especially ketoconazole.Methodsimmunohistochemistry was performed on skin samples to evaluate the density ofM. ovalisand to disclose deposits of immunoreactants at the level of the yeasts inside the stratum corneum.ResultsM. ovaliswas always decorated with the antibody to Factor XIIIa. suggesting the presence of a transglutaminase in the yeast wall. Deposits of IgG and C3 were present underneath and in close apposition to collections ofM. ovalisin seborrheic dermatitis, and absent in control materials, including various types of dermatitis.ConclusionThe close topographical relationship betweenM. ovalis, IgG and C3 deposits is a new evidence suggesting a unique inflammatory reaction to the yeast in seborrheic dermatitis.

ISSN:0926-9959    

DOI:10.1111/j.1468-3083.1995.tb00277.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY

摘要:

AbstractA 64‐year‐old man presented with multiple, rapidly growing painful ulcers on the legs, buttocks, hands and the nose, suggesting pyoderma gangrenosum. Laboratory investigations, especially autoantibodies such as high‐titered speckled antinuclear antibodies, anti‐dsDNA, anti‐RNP, anti‐Ro, anti‐La, and anticardiolipin antibodies both of the IgG and IgM type, signs of mild non‐deforming arthritis, renal and hematologic involvement suggested the diagnosis SLE presenting as pyoderma gangrenosum. A combination of azathioprine and prednisolone completely resolved the pyoderma skin lesions. A brief overview on pyoderma gangrenosum associated systemic diseases and current treatment moda

ISSN:0926-9959    

DOI:10.1111/j.1468-3083.1995.tb00278.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY

摘要:

AbstractBackground of studyPolythelia is a cutaneous marker of congenital diseases of the kidneys. Lateral displacement of the nipples (e.g. laterally located to their respective midclavicular lines) is considered a further sign of renal disorders, particularly of bilateral renal hypoplasia, as reported by Fleisher in a detailed study on seven infants.SubjectWe observed a 45‐year‐old white man with his morphologically normal nipples displaced on the lateral aspects of the trunk without any other consistent clinical features such as accessory nipples or areolae, gonadal dysgenesis, face or car anomalies.Aims and methodsIn order to reveal congenital abnormalities of the kidneys and the urinary collecting systems the following investigations were undertaken: renal ultrasound, intravenous pyelography. abdomen CT and NMR scans, urethrocystography, transurethral cystoscopy, urinalysis, laboratory tests including karyotype, ECG and cardiovascular evaluation.ResultsInstrumental findings disclosed a hypoplastic left kidney in an ectopic site, located below the right kidney (cross type of renal ectopy) without any connection between their urinary‐ collecting systems. Complex malformations of the urinary tract such as an orthotopic narrow right ureteral orifice and ridge, a large‐sized diverticulum on the left wall of the bladder were also present. Moreover, a tumour on the upper pole of the right kidney, 20 mm in diameter, with a histological picture of renal‐cell carcinoma was detected.ConclusionsA lateral displacement of the nipples is a clue for the presence of renal hypoplasia both bilateral and unilateral. The significance of this association is unclear and its occurrence is probably under

ISSN:0926-9959    

DOI:10.1111/j.1468-3083.1995.tb00279.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY

摘要:

AbstractWe report on one patient suffering from amyopathic dermatomyositis, and two patients with transient or mild muscle involvement, respectively. The rare subset of amyopathic dermatomyositis is characterized by benign clinical course and prognosis. Leading cutaneous symptoms are heliotropic rash, periorbital violaceous‐red erythema and edema, erythematous lichenoid plaques at the dorsum of the hands and fingers, hyperkeratotic, hyperesthetic eponychium, nailfold capillary abnormalities and the skin histology, while itching and photosensitivity are optional features. On the other hand, clinical or laboratory evidence of muscle involvement is absent for at least 2 years. The two patients with transient or mild muscle involvement point to transitional forms between amyopathic and classical dermatomyositis. As differential diagnosis lupus erythematosus, (photo)contact eczema, lichen planus, psoriasis, seborrhoic dermatitis and atopic dermatitis, as well as polymorphic light eruption and erythroderma, should be considered. Association with internal malignancy is rare, but is to be excluded. Waiting, hydroxychlorochine and systemic glucocorticoids are the steps of treatment, depending on the clinical cours

ISSN:0926-9959    

DOI:10.1111/j.1468-3083.1995.tb00280.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY

摘要:

AbstractObjectiveThe aim of this study was to assess the clinical efficacy of long‐term (>6 months) oral fumarate maintenance treatment regimen and to determine its adverse effect profile.BackgroundWe previously showed the efficacy of oral fumarate treatment in psoriasis. However, little is known about long‐term maintenance therapy with oral fumarates. Because of concern about renal toxicity and/or other potentially hazardous adverse effects, their role in the long‐term management of psoriasis is still controversial and limited.MethodsClinical data and laboratory parameters of 83 psoriasis patients who were treated with oral fumarates during an uninterrupted period of 6 or more months, were collected and subsequently analysed.ResultsIn 31 of the 83 patients the oral fumarate therapy was discontinued preliminarily (<6 months) because of intolerable adverse effects (9 patients), lack of clinical efficacy (16 patients), insurance refunding problems (4 patients) and lost to follow‐up (2 patients), A major improvement of the psoriasis was present in 41 of the 83 patients. Long‐term oral fumarate maintenance therapy was accompanied by subjective adverse effects, mainly flushing (28 patients) and gastrointestinal upset (15 patients) and by a relative lymphocytopenia (35 patients).ConclusionOral fumarates are effective well tolerated drugs suitable for long‐term management of psoriasis. However, this systemic therapy still has to be considered experimental and should only be performed under strictly controlled conditions. The cause and the clinical relevance of the relative lymphocytopenia, which occurs in a high percentage of patients during long‐term oral fumarate maintenance treatment regimen are unknown and still have to

ISSN:0926-9959    

DOI:10.1111/j.1468-3083.1995.tb00281.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY

摘要:

AbstractAimTo evaluate the presence of skin diseases in diabetic children and adolescents and analyse the risk factors involved.BackgroundThere are few studies in pediatric population with type 1 diabetes mellitus and these present conflicting resultsSetting and PatientsThe Department of Pediatrics and Dermatology, University of Chieti, Italy. A group of 146 (86 female, 60 male) children. Their mean age ± SD was 13.9 ± 7.8 (range: 2.1‐18.0) years; their duration of disease was 10.7 ± 8.8 (range: 1.5‐17.3) years.ResultsThirty‐six patients showed skin problems: the most frequent disease was skin infection, followed by necrobiosis lipoidica; this last disorder is linked to the presence of microvascular complications.ConclusionsThe skin problems were more frequent in children with long duration of disease than in patients with a duration less than 7 years. All the patients who had limited joint mobility showed sclerodema, Dermatological evaluation is strongly reccomended in children with type 1 diabetes

ISSN:0926-9959    

DOI:10.1111/j.1468-3083.1995.tb00282.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY

摘要:

AbstractBackgroundHyperpigmentation of skin, mucous membranes and nails has been described in patients with acquired immune deficiency syndrome (AIDS).Patients and methods7 AIDS patients affected with melasma‐like facial hyperpigmentation were studied. The patients had human immunodeficiency virus infection associated with recurrent mucocutaneous and systemic opportunistic infections. All had a low T4‐CD4 helper cell count and four of them died of severe infections, caused by cytomegalovirus (CMV), mycobacteria (Mycobacterium tuberculosisorAvium) andPneumocystis cariniipneumonia. In these patients the autopsy showed intense infiltration of the adrenal glands. One of them died of Waterhouse‐Friderichsen syndrome; her autopsy showed a massive presence of cytomegalovirus in the adrenal glands.ResultsIn 4 patients dosages of testosterone, cortisol, T3, T4, TSH gave normal results. The level of DHEA‐S was below normal revealing an adrenal insufficiency. The α‐MSH test in 12 patients (4 patients with AIDS and facial hyperpigmentation and 8 volunteers with AIDS, but without pigmented facial lesions) revealed blood levels of α‐MSH above the norm (60.33 pg/ml standard deviation 13.21). The α‐MSH test in 20 healthy subjects revealed a mean value of 44.40 pg/ml (standard deviation 10.47). The biopsy of melasma revealed that melanocytes were present in normal numbers and size with a localized increase of melanin pigment in the basal cell layer.ConclusionAn increased production of ACTH and its derivatives such as α‐MSH pituitary may be the cause of hyperpigmentati

ISSN:0926-9959    

DOI:10.1111/j.1468-3083.1995.tb00283.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY