摘要:

AbstractThis review summarises the present knowledge concerning the decomposition by self‐irradiation of compounds labelled with the radioisotopes, carbon‐14, hydrogen‐3 (tritium), sulphur‐35, selenium‐75, chlorine‐36, phosphorus‐32, iodine‐125, iodine‐131, cobalt‐57 and cobalt‐58. A discussion of the methods which can be used for the control of this decomposi

ISSN:0022-2135    

DOI:10.1002/jlcr.2590020102

出版商:John Wiley&Sons, Ltd.    

年代:1966

数据来源: WILEY

摘要:

AbstractLa méthode employée présentant L'avantage de ne pas entraǐner de dilution isotopique, L'activité spécifique des produits obtenus est celle de la base marquée de départ. La technique de purification employée garantit une pureté supérieure à 99,5%.La formation épisodique de substances secondaires radioactives indique que certaines cultures contiennent une désaminase active sur les desoxyribonucléoside puriques. Une activité nucléosidasique agissant sur thymidine et d‐uridine a é

ISSN:0022-2135    

DOI:10.1002/jlcr.2590020103

出版商:John Wiley&Sons, Ltd.    

年代:1966

数据来源: WILEY

摘要:

AbstractPhenyl‐3H‐sec‐butyl disulphide was synthesized via Wilzbach irradiated phenyl benzenethiolsulphonate and phenyl‐sec‐butyl‐35S1‐disulphide was synthesized via elemental sulphur‐35. The two disulphides were mixed to give phenyl‐3H‐sec‐butyl‐35S1‐disulphide which was assayed by liqu

ISSN:0022-2135    

DOI:10.1002/jlcr.2590020104

出版商:John Wiley&Sons, Ltd.    

年代:1966

数据来源: WILEY

摘要:

AbstractL'action de la cyanamide14C sur L'azothydrate de sodium, en solution aqueuse acide à 70‐75 °C, fournit L'amino‐5 tétrazole14C. Après purification sur résine échangeuse Dowex 50‐ W‐12, le rendement radioactif est de 76% par rapport à Ba14CO3. L'activité spécifique est de 21,8 mCi/mM. On récupère comme produit secondaire de L'urée14C avec un rendement de 11% pa

ISSN:0022-2135    

DOI:10.1002/jlcr.2590020105

出版商:John Wiley&Sons, Ltd.    

年代:1966

数据来源: WILEY

摘要:

AbstractThe diuretic drug triamterene was labelled with carbon‐14 by condensing the intermediate phenylacetonitrile‐1‐14C with 2,4,6‐triamino‐5‐nitrosopyrimidine.The tritiated triamterene was prepared by direct synthesis from toluene‐3,4‐3H1/2and toluene‐3‐3H. The3H‐toluenes were prepared in excellent radiochemical yield by hydrolyzing the dry Grignard reagent of the appropriate bromotolue

ISSN:0022-2135    

DOI:10.1002/jlcr.2590020106

出版商:John Wiley&Sons, Ltd.    

年代:1966

数据来源: WILEY

摘要:

Abstract35S‐(5′‐Deoxyadenosine‐5′)‐L‐methionine (35S‐adenosylmethionine, C15H23N6O5S+) has been isolated in useful amounts from yeast cells which were cultivated in a medium containing35SO—‐4. Procedures for purification and an

ISSN:0022-2135    

DOI:10.1002/jlcr.2590020107

出版商:John Wiley&Sons, Ltd.    

年代:1966

数据来源: WILEY

摘要:

AbstractWe compare the phosphorylation of 6‐3H‐TdR and 2‐14C‐TdR to TMP, TDP and TTP by tissue extracts and to TMP by purified kinase preparations. The rate of phosphorylation of 6‐3H‐TdR is only 0.6 to 0.8 that of 2‐14C‐TdR. The same isotopic discrimination exists between methyl‐labelled thymidines. In mixtures of3H‐TdR and14C‐TdR incubated together with a liver extract, the isotopic ratio is lower in the products than in the substrate. Degradation products of3H‐TdR do not seem to interfere with enzymatic activity. This isotopic discrimination is tentatively ascribed to an isotopic effect of3H which is mainly detectable at the high substrate/enzyme ratios prevailing in the in vitr

ISSN:0022-2135    

DOI:10.1002/jlcr.2590020108

出版商:John Wiley&Sons, Ltd.    

年代:1966

数据来源: WILEY

摘要:

AbstractAddition of D‐tryptophan to the growth media of Streptomyces V‐187 results in an inhibition of actinomycin production, while growth of the microorganism appears to be unaffected. L‐tryptophan overcomes the inhibition brought about by the D‐stereoisomer.D‐[benzene ring‐14C]‐tryptophan is taken up by the cells ofStreptomycesV‐187 and incorporated into proteins and actinomycin almost to the same extent of L‐[benzene ring‐14C]‐tryptophan, though at a slower rate. The benzene ring of both stereoisomers contributes only to the phenoxazinone residue of the actinomycin molecule. Indeed, D, L‐[methylene‐14C]‐tryptophan is incorporated into actinomycin only to a very small extent. Other possible precursors of the chromophoric residue of actinomycin, [benzene ring‐14C]‐indolepyruvic acid, [benzene ring‐14C]‐benzoic acid and[uniformly‐14C]‐shikimic acid, were not taken

ISSN:0022-2135    

DOI:10.1002/jlcr.2590020109

出版商:John Wiley&Sons, Ltd.    

年代:1966

数据来源: WILEY

ISSN:0022-2135    

DOI:10.1002/jlcr.2590020110

出版商:John Wiley&Sons, Ltd.    

年代:1966

数据来源: WILEY

ISSN:0022-2135    

DOI:10.1002/jlcr.2590020111

出版商:John Wiley&Sons, Ltd.    

年代:1966

数据来源: WILEY