| 年代：1999 |
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Volume 34 issue 6
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| 1. |
Study Duration and Validity |
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Hypertension: Journal of The American Heart Association,
Volume 34,
Issue 6,
1999,
Page 11-11
Feng He,
Nirmala D. Markandu,
Giuseppe A. Sagnella,
Graham A. MacGregor,
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ISSN:0194-911X
出版商:OVID
年代:1999
数据来源: OVID
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| 2. |
Vasodilator Response to Local Hyperinsulinemia |
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Hypertension: Journal of The American Heart Association,
Volume 34,
Issue 6,
1999,
Page 12-12
Carmine Cardillo,
Julio Panza,
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ISSN:0194-911X
出版商:OVID
年代:1999
数据来源: OVID
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| 3. |
Can Knockout Mice Help Dissect Relevant Genes in Hypertension? Evidence and Confounding Factors |
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Hypertension: Journal of The American Heart Association,
Volume 34,
Issue 6,
1999,
Page 14-14
Nour-Eddine Rhaleb,
Edward G. Shesely,
Oscar A. Carretero,
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ISSN:0194-911X
出版商:OVID
年代:1999
数据来源: OVID
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| 4. |
ANP Bioactivity in Obese Hypertensives |
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Hypertension: Journal of The American Heart Association,
Volume 34,
Issue 6,
1999,
Page 16-16
Paolo Dessì-Fulgheri,
Riccardo Sarzani,
Massimiliano Serenelli,
Paola Tamburrini,
Diego Spagnolo,
Laura Giantomassi,
Emma Espinosa,
Alessandro Rappelli,
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ISSN:0194-911X
出版商:OVID
年代:1999
数据来源: OVID
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| 5. |
Chronic Salt Loading and the Expression of Adenosine Receptor Subtypes |
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Hypertension: Journal of The American Heart Association,
Volume 34,
Issue 6,
1999,
Page 18-18
Ai-Ping Zou,
Feng Wu,
Pin-Lan Li,
Allen W. Cowley,
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ISSN:0194-911X
出版商:OVID
年代:1999
数据来源: OVID
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| 6. |
ACE-Gene Polymorphism and Endothelial Dysfunction in Normal Humans |
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Hypertension: Journal of The American Heart Association,
Volume 34,
Issue 6,
1999,
Page 20-20
Robert Butler,
Andrew D. Morris,
Brian Burchell,
Allan D. Struthers,
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ISSN:0194-911X
出版商:OVID
年代:1999
数据来源: OVID
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| 7. |
Peptide Probes |
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Hypertension: Journal of The American Heart Association,
Volume 34,
Issue 6,
1999,
Page 1177-1177
Irvine H. Page,
Walter C. Alvarez,
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ISSN:0194-911X
出版商:OVID
年代:1999
数据来源: OVID
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| 8. |
Reappearance of the J-Shaped Curve |
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Hypertension: Journal of The American Heart Association,
Volume 34,
Issue 6,
1999,
Page 1179-1179
Edward Frohlich,
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ISSN:0194-911X
出版商:OVID
年代:1999
数据来源: OVID
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| 9. |
J-Shaped Relation Between Blood Pressure and Stroke in Treated Hypertensives |
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Hypertension: Journal of The American Heart Association,
Volume 34,
Issue 6,
1999,
Page 1181-1181
Zoltán Vokó,
Michiel Bots,
Albert Hofman,
Peter Koudstaal,
Jacqueline Witteman,
Monique Breteler,
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摘要:
The objective of this study was to investigate the relationship between hypertension and risk of stroke in the elderly. The study was performed within the framework of the Rotterdam Study, a prospective population-based cohort study. The risk of first-ever stroke was associated with hypertension (relative risk, 1.6; 95% CI, 1.2 to 2.0) and with isolated systolic hypertension (relative risk, 1.7; 95% CI, 1.1 to 2.6). We found a continuous increase in stroke incidence with increasing blood pressure in nontreated subjects. In treated subjects, we found a J-shaped relation between blood pressure and the risk of stroke. In the lowest category of diastolic blood pressure, the increase of stroke risk was statistically significant compared with the reference category. Hypertension and isolated systolic hypertension are strong risk factors for stroke in the elderly. The increased stroke risk in the lowest stratum of blood pressure in treated hypertensive patients may indicate that the therapeutic goal of “the lower the better” is not the optimal strategy in the elderly.
ISSN:0194-911X
出版商:OVID
年代:1999
数据来源: OVID
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| 10. |
Association and Linkage Analyses of Glucocorticoid Receptor Gene Markers in Essential Hypertension |
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Hypertension: Journal of The American Heart Association,
Volume 34,
Issue 6,
1999,
Page 1186-1186
Ruby Lin,
William Wang,
Brian Morris,
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摘要:
Suggestive evidence has been obtained in a “4-corners” study for involvement of the glucocorticoid receptor gene (GRL) in genetic variation in blood pressure. Therefore, we tested markers at theGRLlocus for association and linkage with essential hypertension (HT). For the association study, we used a well-characterized group of 129 white Australians of Anglo-Celtic extraction who had HT, a strong family history of HT (2 parents with the disease), and early-onset moderate-to-severe disease. Controls were 195 normotensive white subjects whose parents were normotensive past the age of 50 years. For the linkage study, we used 175 sibling pairs of similar ancestry. The case-control groups were genotyped for an Asn363Ser variant in exon 2, a G/T variant in intron 4, and a microsatellite marker (D5S207) tightly linked (<200 kb) toGRL. For the groups as a whole, no association or linkage was observed after analysis of data by a variety of statistical tests. Analysis of sibling-pair data gave an exclusion score of −3.8 for the logarithm of the odds for linkage, indicating significant nonlinkage. However, in females, weak association of the intron 4 polymorphism with HT (P=0.03), as well as with systolic and diastolic blood pressure in all subjects (P=0.04 and 0.03), was observed, and in the case of theD5S207marker, association with HT was apparent in males (P=0.0001). Thus, although our results provide no overall support forGRLin HT etiology, apparent gender-specific associations could exist in this genomic region, possibly reflecting correlated occurrence with (an)other metabolic syndrome disorder(s).
ISSN:0194-911X
出版商:OVID
年代:1999
数据来源: OVID
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