ISSN:0105-4538    

DOI:10.1111/j.1398-9995.1978.tb01500.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

ISSN:0105-4538    

DOI:10.1111/j.1398-9995.1978.tb01501.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

Basophils from patients with rheumatoid arthritis (RA) respond to RNA, DNA and immune complexes [aggregated IgG] with histamine release. The RNA response was well correlated to the clinical activity of the disease since histamine liberation was found in all patients with severe activity, whereas no liberation was observed in patients with moderate or quiescent activity. A less significant correlation was obtained with DNA and aggregated IgG. In contrast, no response was obtained with RNA, DNA and aggregated IgG in patients with systemic lupus erythematosus (SLE) or in controls. In the RA and the SLE groups no significant correlation was found between the response of RNA, DNA and aggregated IgG and the serum titres of anti‐DNA and antinuclear antibodies. No difference in basophil cell count in peripheral blood and basophil histamine content was found between RA. SLE and controls. Our results point 10 an involvement of an autoimmune type I reaction in the pathogenesis of RA directed against the nuclear components RNA and DNA and against immune complexe

ISSN:0105-4538    

DOI:10.1111/j.1398-9995.1978.tb01502.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

The radioallergosorbent test (RAST) was used to demonstrate IgE. Antibodies toCladosporium herbarumin 35 children. Freeze‐dried samples of Cladosporion herbarum were obtained from two commercial producers, extracted and used for the preparation of two RAST disc series which were Compared with the commercially available PhadebasCladosporium herbarumdiscs. Marked qualitative differences were foun

ISSN:0105-4538    

DOI:10.1111/j.1398-9995.1978.tb01503.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

Three allergens, antigens Nos, 3, 25. and 30, were isolated from freeze‐dried aqueous extract of timothy pollen by various combinations of anionic and cationic exchange and gel chromatography. The allergens were all of protein nature and contained less than 2% (w/w) immunochemically detectable impurities Molecular weight and pl's were determined to<10 × 103, 15 × 103and 3.9, 4.5, 9.4. respectively, and antigen 25 was determined as the major component of the earlier isolated antigen B. Amino acid analyses performed on antigens 3 and 50 revealed large variations in the amino acid composition. The allergenic activities were verified by means of RAST inhibition and prick tests and proved antigen 25 to be quantitatively the most important allergen of tintothy pol

ISSN:0105-4538    

DOI:10.1111/j.1398-9995.1978.tb01504.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

Anti‐DNA antibody determination in strum is increasingly used because it supports the diagnosis of systemic lupus erythematosus (SLE) with high selectivity. The present work evaluates several of the technical variables of the Fair radioimmunoassay for anti‐DNA antibody determination and describes a recommendable procedure, emphasizes the most important sources of error and gives the range of normal blood donors and a group of hospital patients without

ISSN:0105-4538    

DOI:10.1111/j.1398-9995.1978.tb01505.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

ISSN:0105-4538    

DOI:10.1111/j.1398-9995.1978.tb01506.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

ISSN:0105-4538    

DOI:10.1111/j.1398-9995.1978.tb01507.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

ISSN:0105-4538    

DOI:10.1111/j.1398-9995.1978.tb01508.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY