ISSN:0105-4538    

DOI:10.1111/j.1398-9995.1982.tb04111.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

ISSN:0105-4538    

DOI:10.1111/j.1398-9995.1982.tb04121.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

Qualitative and semi‐quantitative microscopic analyses were performed on the mite populations in dust samples collected from the byres and hay and grain storages of 11 farms in Eastern Finland. Storage mites were found in all farms. The mite fauna was more abundant in the byres and hay storages than in the grain storages. The most common species or genera wereAcarus siro, Acarus farris, Glycyphagus domesticus, Lepidoglyphus destructor, Cheyletus eruditus, Tydeusspp., andTarsonemusspp. The results imply that also in northern climates storage mites should be considered as possible causes of allergic disorders among farming population

ISSN:0105-4538    

DOI:10.1111/j.1398-9995.1982.tb04112.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

The possible allergenicity of an insect pollinated weed,Echium plantagineum, was investigated in a rural area of Australia. Sixty‐one subjects with respiratory allergy were studied. Positive skin test reactions to defatted ammonium bicarbonate extract of pollen were found in over 60% of subjects, and positive RAST tests in a similar number. The question of cross‐reactivity between weed pollens is discussed. The pollen ofE. plantagineumwas shown to reach the atmosphere in significant amounts about 1 month before the peak grass pollinating period. Evidence that the pollen ofE. plantagineumbecomes airborne and elicits an IgE response suggests that further attention should be directed to weed pollens as potential allerg

ISSN:0105-4538    

DOI:10.1111/j.1398-9995.1982.tb04113.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

The kinetics of the 5‐HT‐uptake by platelets in platelet‐rich plasma (PRP) and PRP diluted with autologous platelet‐poor plasma (PRP/PPP) were determined in normal subjects, patients with asymptomatic exogenous asthma and those with symptomatic endogenous asthma.In normal subjects the 5‐HT‐uptake by platelets strictly obeyed Michaelis‐Menten's kinetics. In patients with asymptomatic exogenous asthma, the active 5‐HT‐transport was moderately distorted in PRP and severely altered in PRP/PPP. Patients with symptomatic endogenous asthma exhibited already in PRP a dramatic transport disturbance.The alteration of the active 5‐HT‐transport was characterized by increasing uptake inhibition by rising 5‐HT concentrations in plasma. This phenomenon could be due to changes in the platelet environment, defects in the platelet membrane or intrinsic platelet disorders. It is concluded that asthmatics have a genetically or later acquired platelet disorder, which is more clearly observed in patients with symptomatic endogenous asthma than in those with asympt

ISSN:0105-4538    

DOI:10.1111/j.1398-9995.1982.tb04114.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

Azelastine, a newly synthesized anti‐allergic agent, was tested for its effects on guinea pig macrophage chemotaxis and phagocytosis. As specific macrophage chemo‐attractants, we used macrophage chemotactic factorsaandc; separated and highly purified from inflamed skin sites.Macrophage chemotaxis induced by skin extract or chemotactic factors was significantly suppressed by a low concentration of the agent (1 μg/ml); the effect was dose‐dependent. The inhibition of chemotaxis was reversible, because chemotactic activity was restored when the agents was removed by washing cells before chemotactic assay. Inactivation of chemotactic factors was not detected by mixing azelastine and factorsaandc.Azelastine may directly interact with macrophages to decrease their chemotactic responsiveness.β‐Glucuronidase activity in the medium and macrophages after phagocytosis of polystyrene latex particles was not affected by this agent at concentrations ranging from 1 to 10 μg/ml. The phagocytosis of latex particles or sheep red blood cells opsonized with IgG antibodies (EA) and anchoring of macrophages to substrate were not inhibited and azelastine did not damage the macrophages as determined by lactate dehydrogenase (LDH) rel

ISSN:0105-4538    

DOI:10.1111/j.1398-9995.1982.tb04115.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

The quantity and quality of antigen‐specific IgE against purified major allergens from cow hair and dander was measured by a double‐antibody radioimmunoassay. In serum from patients with allergic asthma to cow the affinity constant varied from 1 to 150 × 1091/mol and the number of antibody combining sites from 0.01 to 0.4 × 10−9mol/1 serum for each

ISSN:0105-4538    

DOI:10.1111/j.1398-9995.1982.tb04116.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

The chemotactic activity of serum has been monitored in eight patients with bronchial asthma after inhalation of an allergen. Lactoferrin and lysozyme were measured in serum simultaneously as markers of neutrophil and monocyte/macrophage activity and turnover. The heat‐labile chemotactic activity of serum showed a two‐phase response with an initial reduction in activity (median = 37.5 min after challenge) (P<0.05) followed by an increased activity (median = 60 min after challenge) (P<0.01). The consistency of this pattern was highly significant (P<0.0005). Heat‐stable chemotactic activity was significantly increased (P<0.01) 15 min after challenge.The initial reduction in heat‐labile chemotactic activity was observed only in those patients who developed a late asthmatic response and could suggest the involvement of immune complex‐mediated reactions since a similar reduction in heat‐labile chemotactic activity is produced byin vitroactivation of serum with aggregated IgG.The increased heat‐labile chemotactic activity showed a close relationship (P<0.01) to the extent of the immediate reduction in PEF‐rate. No relationship was discernible between the chemotactic activity and the eventually occurring rise in PMN blood count. In contrast the activity and turnover of PMNs after challenge as reflected by serum‐lactoferrin levels were significantly reduced (P<0.01). A close correlation (P<0.001) was found between the heat‐labile chemotactic activity in serum and the serum‐levels of lysozyme, suggesting the involvement of macrophages/monocytes in the asthmatic reaction and in the generation of the heat‐labile chemotactic activity found in serum aft

ISSN:0105-4538    

DOI:10.1111/j.1398-9995.1982.tb04117.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

ISSN:0105-4538    

DOI:10.1111/j.1398-9995.1982.tb04118.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

ISSN:0105-4538    

DOI:10.1111/j.1398-9995.1982.tb04119.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY