摘要:

AbstractIn their severest forms, pre‐eclampsia and eclampsia may be life‐threatening complications of pregnancy. We describe a patient with severe post‐partum eclampsia characterized by seizures, deep coma, hypertension, renal insufficiency, coagulopathy, and microangiopathic hemolysis. The patient responded to treatment that included intensive plasma exchange, and she achieved full recovery. Our case supports the use of plasma exchange in patients with severe pre‐eclampsia and eclampsia. © 1992 Wiley

ISSN:0733-2459    

DOI:10.1002/jca.2920070102

出版商:John Wiley&Sons, Inc.    

年代:1992

数据来源: WILEY

摘要:

AbstractWe describe here a case of a severe, life‐threatening, serum sickness‐like reaction in a patient with refractory immune thrombocytopenia treated with protein A immunomodulation. © 1992 Wiley‐Lis

ISSN:0733-2459    

DOI:10.1002/jca.2920070103

出版商:John Wiley&Sons, Inc.    

年代:1992

数据来源: WILEY

摘要:

AbstractThe collection efficiency (CE) of the Fenwall CS3000 continuous flow blood cell separator in the apheresis of peripheral blood stem cells during haemopoietic recovery following myelosuppressive chemotherapy was analysed. Ninety‐three aphereses were performed in 19 patients using procedure 3 on the Fenwal CS3000. The overall CE was calculated from the pre‐apheresis cell counts and the stated blood volume processed. Instantaneous CE was calculated from cell counts in the inlet and return lines. The overall mononuclear cell and granulocyte‐macrophage colony forming unit CE were 64.0% and 55.8%, respectively, significantly lower than the instantaneous CEs of 94.5% and 95.4%, respectively (P = 0.0001, t test, for both comparisons). Three factors unrelated to machine performance contributed to the lower overall CE despite a high instantaneous CE: (I) A fall in the patient's mononuclear cell counts during apheresis leading to an overestimation of the cells available for collection, (2) dilution of blood by anti‐coagulant, and (3) the operational dead space of the Fenwal CS3000. The overall CE corrected for these 3 factors approximated the instantaneous CE closely. Thus there is little room for further enhancement of machine performance because the Fenwal CS3000 is already operating with a very high instantaneous CE. To achieve major improvement in the yield of peripheral blood stem cell harvests, more effective mobilization protocols and better timing of apheresis are required. © 1992 Wiley

ISSN:0733-2459    

DOI:10.1002/jca.2920070104

出版商:John Wiley&Sons, Inc.    

年代:1992

数据来源: WILEY

摘要:

AbstractInadvertent hypothermia due to massive infusion of stored blood can be prevented by pretransfusion warming. One approach is the heating of individual packs by means of electromagnetic conduction, which is a method safely used over the last 25 years. The prototype instrument, which has now been re‐engineered, can effectively raise the temperature of a unit of blood to approximately 33°C in less than 3 minutes. Using this new model, we found, in vitro, a modest increase in free plasma haemoglobin, but this was not accompanied by any change in potassium or lactic dehydrogenase levels and the mean red cell fragility was unaltered. In vivo, the survival of autologous red cells that had been stored for 33 days and then infused as a concentrate, having a mean haematocrit of 0.60, was measured at 24 hours and 21 days. Each donor acted as his own control. In paired studies, pretransfusion radiofrequency heating was shown to have no deleterious effect when compared to measurements using the unwarmed blood pack. It is concluded that this method can be recommended as safe. © 1992 Wiley‐Liss

ISSN:0733-2459    

DOI:10.1002/jca.2920070105

出版商:John Wiley&Sons, Inc.    

年代:1992

数据来源: WILEY

ISSN:0733-2459    

DOI:10.1002/jca.2920070106

出版商:John Wiley&Sons, Inc.    

年代:1992

数据来源: WILEY

ISSN:0733-2459    

DOI:10.1002/jca.2920070107

出版商:John Wiley&Sons, Inc.    

年代:1992

数据来源: WILEY

ISSN:0733-2459    

DOI:10.1002/jca.2920070108

出版商:John Wiley&Sons, Inc.    

年代:1992

数据来源: WILEY

ISSN:0733-2459    

DOI:10.1002/jca.2920070109

出版商:John Wiley&Sons, Inc.    

年代:1992

数据来源: WILEY

ISSN:0733-2459    

DOI:10.1002/jca.2920070101

出版商:John Wiley&Sons, Inc.    

年代:1992

数据来源: WILEY