ISSN:0731-5724    

DOI:10.1080/07315724.1986.10720108

出版商:Routledge    

年代:1986

数据来源: Taylor

ISSN:0731-5724    

DOI:10.1080/07315724.1986.10720109

出版商:Routledge    

年代:1986

数据来源: Taylor

ISSN:0731-5724    

DOI:10.1080/07315724.1986.10720110

出版商:Routledge    

年代:1986

数据来源: Taylor

摘要:

Elevation of serum alkaline phosphatase concentration in patients with diabetes mellitus has been observed for several years, but the source and reasons are unknown. We report our experience with 39 diabetics, 38% of whom had an unexplained elevation of serum alkaline phosphatase. Isoenzyme determinations revealed bone fraction as the predominant species. Mean fasting serum glucose was significantly higher in the group with elevated alkaline phosphatase, supporting an association between the severity of diabetes and diabetic bone disease.

ISSN:0731-5724    

DOI:10.1080/07315724.1986.10720112

出版商:Routledge    

年代:1986

数据来源: Taylor

摘要:

We fed 12 men with abnormally high insulin responses to a sucrose load and 12 controls normal diets containing 0, 7.5, or 15% of the calories as pure fructose for 5 weeks each in a crossover design. Purified wheat starch replaced the fructose in the 0 and 7.5% diets. The two groups were matched for age, height, and weight. At the beginning of the study and at the end of each of the three 5-week periods, plasma responses to a sucrose load (2 gm/kg body weight) were measured. Initially there were no significant differences in the plasma fructose, uric acid, or inorganic phosphorus responses of the two groups. Plasma fructose responses to a sucrose load were significantly higher after the men consumed the 7.5 and 15% fructose diets than after the 0% diet. Uric acid responses tended to be greater in the hyperinsulinemic men than in controls and increased as the levels of fructose in the diet increased. The inorganic phosphorus levels after a sucrose load were higher in the hyperinsulinemic men than in controls when they consumed the 7.5 and 15% fructose diets. These results indicate that moderate levels of dietary fructose can affect plasma fructose, uric acid, and inorganic phosphorus levels, especially in hyperinsulinemic men.

ISSN:0731-5724    

DOI:10.1080/07315724.1986.10720113

出版商:Routledge    

年代:1986

数据来源: Taylor

摘要:

We assessed the magnesium status in 67 children with insulin-dependent diabetes mellitus (IDDM) in various degrees of diabetic control and its changes during the evolution of the disease. This was done by measuring fasting serum magnesium and 24-hr urinary magnesium clearances when patients were first studied, as well as subsequently on follow-up. In 23 of these patients the retention of intramuscular magnesium was also assessed in relation to the degree of diabetic control and the duration of the illness. The mean +/−SD serum magnesium levels were significantly lower in diabetic children as compared to nondiabetic controls (1.91 +/−0.22 vs 2.12 +/−0.26 mg/dl, p less than 0.001). Serum magnesium in diabetic children correlated with glycosylated hemoglobins (r = -0.358, p less than 0.001), but not with 24-hr glycosuria (r = -0.296). On follow-up of patients, serum magnesium significantly increased when IDDM control improved and decreased when the control worsened. Diabetic patients had increased urinary magnesium clearances compared to nondiabetic subjects (5.26 +/−3.58 vs 3.60 +/−1.36 cc/min, p less than 0.05). All but five of the 23 patients given the magnesium load retained more than 40% of the dose, with a mean +/−SD retention of 58.7 +/−5.1%. There was no correlation between the amount of retained magnesium and the duration of the illness, degree of diabetic control, amount of glycosuria, magnesuria, magnesemia, glycosylated hemoglobins, or serum lipids. The data confirm that lower than control serum magnesium levels occur frequently among children with poorly controlled IDDM. Moreover, there might be magnesium deficiency in IDDM, as indicated by the high retention of magnesium when given intramuscularly. The deficiency of this ion may or may not be accompanied by decreased serum magnesium levels and may result from increased urinary magnesium losses in children with IDDM.

ISSN:0731-5724    

DOI:10.1080/07315724.1986.10720114

出版商:Routledge    

年代:1986

数据来源: Taylor

摘要:

The clinical course of 24 patients with insulin-requiring diabetes mellitus who had received total parenteral nutrition (TPN) was retrospectively analyzed. Routine nutritional assessment disclosed significant depression of anthropometric indices and secretory protein levels in patients with chronic renal failure complicating juvenile onset diabetes mellitus (JODM). Biochemical complications including hypo- or hyperglycemia were significantly more frequent (p less than 0.001) in JODM than in maturity-onset diabetes and found to a lesser degree in patients with renal failure. The catheter infection rate was substantially higher (17%) than usually encountered in TPN therapy. Positive nitrogen balance was achieved in the majority of patients with an average 84% and 92% of estimated protein and caloric requirements being provided. Close monitoring and a protocol of infusion plus supplemental subcutaneous regular insulin was useful in providing adequate TPN safely to these high-risk patients.

ISSN:0731-5724    

DOI:10.1080/07315724.1986.10720115

出版商:Routledge    

年代:1986

数据来源: Taylor

摘要:

Vitamin E (alpha- and gamma-tocopherol) and total lipid concentrations were determined in the serum of 451 healthy human male and female subjects ranging in age from 19 to 70 years. Mean serum alpha-tocopherol concentration (microgram/ml) was 8.82 +/−2.84 (SD) and gamma-tocopherol concentration was 1.35 +/−0.70. The concentration of alpha-tocopherol increased significantly with age, as well as with total lipid; gamma-tocopherol concentration remained unchanged with age. The data also indicated that subjects with higher serum alpha-tocopherol had lower gamma-tocopherol levels and vice versa for subjects with higher gamma levels. A close interrelationship and competition appeared to exist between these two vitamers.

ISSN:0731-5724    

DOI:10.1080/07315724.1986.10720116

出版商:Routledge    

年代:1986

数据来源: Taylor

ISSN:0731-5724    

DOI:10.1080/07315724.1986.10738081

出版商:Routledge    

年代:1986

数据来源: Taylor

ISSN:0731-5724    

DOI:10.1080/07315724.1986.10738080

出版商:Routledge    

年代:1986

数据来源: Taylor