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1. |
Neuropharmacological Comparison of Cyclazocine and Imipramine |
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Pharmacology,
Volume 9,
Issue 2,
1973,
Page 65-73
W.G Drew,
R.P. White,
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摘要:
A neuropharmacological comparison was made between cyclazocine and imipramine in rabbits made tolerant to the initial excitation induced by cyclazocine. Both compounds increased EEG synchrony, raised the voltage required to produce EEG activation, and induced mydriasis without concomitantly inducing depression. In combination, low doses of cyclazocine and imipramine induced a synergistic increase in synchrony and inhibited the EEG activation usually produced by physostigmine and methamphetamine. The results support the hypothesis that some narcotic antagonists exert central effects which are not related to occupation of narcotic receptors, and that such effects may be related to reported clinical antidepressant actions.
ISSN:0031-7012
DOI:10.1159/000136369
出版商:S. Karger AG
年代:1973
数据来源: Karger
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2. |
Pharmacology of Some New Dicholinesters |
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Pharmacology,
Volume 9,
Issue 2,
1973,
Page 73-78
K. Vidal-Beretervide,
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ISSN:0031-7012
DOI:10.1159/000135332
出版商:S. Karger AG
年代:1963
数据来源: Karger
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3. |
Pharmacological Studies on the Anti-Inflammatory Effect of a Semi-Synthetic Polysaccharide (Pentosan Polysulfate) |
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Pharmacology,
Volume 9,
Issue 2,
1973,
Page 74-79
D.A. Kalbhen,
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摘要:
Certain biochemical characteristics of pentosan polysulfate (SP 54) indicated possible antiphlogistic properties of this substance. Our extensive investigations with different models of acute inflammatory reactions (rat paw edema induced by hyaluronidase, trypsin, carrageenin or kaolin) have shown that pentosan polysulfate has a pronounced anti-inflammatory and antiphlogistic effect, although it has no analgetic properties. In contrast to other well-known antiphlogistic drugs, such as salicylate, pyrazolone or anthranilic acid derivatives, pentosan polysulfate exerts its strong anti-inflammatory effect on all types of experimental edema. This outstanding antiphlogistic and anti-inflammatory potency of pentosan polysulfate can be explained by a suppression of hyaluronidase, histamine and certain complement factors as well as by its specifically vasotropic and stabilizing effects.
ISSN:0031-7012
DOI:10.1159/000136370
出版商:S. Karger AG
年代:1973
数据来源: Karger
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4. |
Pharmacology of Dimethylaminoethanol P-Chlorophenoxyacetate Methiodide |
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Pharmacology,
Volume 9,
Issue 2,
1973,
Page 79-83
K. Vidal-Beretervide,
M. Monti,
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ISSN:0031-7012
DOI:10.1159/000135333
出版商:S. Karger AG
年代:1963
数据来源: Karger
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5. |
Study of the Antiproteolytic Activity of Fenamates and Indomethacin |
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Pharmacology,
Volume 9,
Issue 2,
1973,
Page 80-84
M. Stančiková,
K. Trnavský,
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摘要:
The effect of mefenamic acid, flufenamic acid and of indomethacin on tryptic hydrolysis of bovine albumin (BA) and of the syn thetic substrates N-benzoyl-DL.-arginine-p-nitro anilide (BAPNA) and L-lysin-p-nitroanilide (LPA) was studied in vitro. Both fenamates and indomethacin inhibited tryptic hydrolysis of BA, indomethacin being more active. The failure of the tested antirheumatic drugs to inhibit BAPNA and LPA hydrolysis and the kinetics of BA decomposition showed that the binding of the antirheumatic drugs to the substrate (BA) is decisive for the inhibition of tryptic hydrolysis.
ISSN:0031-7012
DOI:10.1159/000136371
出版商:S. Karger AG
年代:1973
数据来源: Karger
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6. |
The Influence of Pyridoxine Disulphide on the Electroencephalogram of Free, Unanaesthetized Cats |
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Pharmacology,
Volume 9,
Issue 2,
1973,
Page 84-92
G. Sierra,
F. Reinoso-Suárez,
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ISSN:0031-7012
DOI:10.1159/000135334
出版商:S. Karger AG
年代:1963
数据来源: Karger
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7. |
A Comparison of Some Pharmacological Effects ofEscherichia coli(E. coli)L-Asparaginase andE. coliEndotoxin in Rabbits |
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Pharmacology,
Volume 9,
Issue 2,
1973,
Page 85-96
E.H. Herman,
R.M. Mhatre,
D.A. Cooney,
I.P. Lee,
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摘要:
Escherichia coli (E. coli) endotoxin and E. coli L-asparaginase produced diarrhea, rapid respiration and nasal discharge. L-asparaginase caused a greater incidence of tremors, muscle fasciculations and ultimate convulsions than endotoxin. The maximal incidence of L-asparaginase toxicity (40–45 %) occurred after 800 or 1,400 IU/kg. Endotoxin toxicity was observed within 24 h, whereas L-asparaginase intoxication developed after 24 h. The blood pressure in animals displaying severe L--asparaginase toxicity was similar to that monitored in the control animals, whereas severe hypotension was found in endotoxin-intoxicated animals. L-asparaginase and endotoxin induced increases in blood glucose and urea nitrogen. The blood urea nitrogen levels returned to control levels by 72 h in surviving animals. Endotoxin also produced elevations in serum glutamic pyruvic transaminase and serum glutamic oxaloacetic transaminase levels. Endotoxin and L-asparaginase produced some histopathological changes in the lung, kidney, liver and spleen. The alterations in the liver and kidney appeared to be more severe after endotoxin treatment. Significant decreases in plasma levels of calcium and magnesium and an increase in plasma phosphorus levels were noted in L-asparaginase-intoxicated animals. These plasma ions were not altered by endotoxin treatment. Thus, the pharmacological effects of L-asparaginase observed in rabbits appear to differ in many respects from that of endotoxi
ISSN:0031-7012
DOI:10.1159/000136372
出版商:S. Karger AG
年代:1973
数据来源: Karger
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8. |
Effect of Pyrogallol on Catechol-Oxy-Methyl-Transferase in Isolated Rabbit Heart |
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Pharmacology,
Volume 9,
Issue 2,
1973,
Page 93-98
A.V. Juorio,
H.J. Barboza,
J.A. Izquierdo,
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ISSN:0031-7012
DOI:10.1159/000135335
出版商:S. Karger AG
年代:1963
数据来源: Karger
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9. |
Influence of Methadone and Sulfapyridine on Mouse Liver and Brain Ribonuclease and Deoxyribonuclease |
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Pharmacology,
Volume 9,
Issue 2,
1973,
Page 97-106
R.K. Datta,
W. Antopol,
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摘要:
Methadone hydrochloride in vitro slightly inhibited RNAase in homogenates of mouse liver and brain and DNAase in brain only. Sulfapyridine alone inhibited RNAase of both liver and brain homogenates slightly and failed to inhibit DNAase of either. Methadone and sulfa pyridine in combination inhibited RNAase of both liver and brain homogenates but the inhibition was less than additive However, this combination markedly inhibited DNAase of brain homogenate. In vivo, the acute administration of methadone did not parallel its in vitro inhibitory effects on RNAase and DNAase. Sulfapyridine inhibited liver RNAase and brain DNAase slightly. The combination did not potentiate the effect obtained with each drug separately. Mice receiving methadone in gradually increasing doses up to 40 mg/kg body weight over 3.5 weeks displayed marked weakness; mortality was about 25 % by the end of the final week. In surviving mice, RNAase and DNAase activities were decreased in liver and brain. Decreases in specific activities of these enzymes occurred in subcellular fractions, i.e., nuclei, mitochondria, microsomes and soluble supernatant from liver and brain tissues of the chronically methadone-treated mice.
ISSN:0031-7012
DOI:10.1159/000136373
出版商:S. Karger AG
年代:1973
数据来源: Karger
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10. |
Unbeeinflußbarkeit der permeationsfördernden Wirkung von Bradykinin durch Antiphlogistica (Dexamethason und Isopyrin) |
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Pharmacology,
Volume 9,
Issue 2,
1973,
Page 99-101
M. Frimmer,
G. Krych,
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ISSN:0031-7012
DOI:10.1159/000135336
出版商:S. Karger AG
年代:1963
数据来源: Karger
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