ISSN:0273-8481    

出版商:OVID    

年代:1984

数据来源: OVID

ISSN:0273-8481    

出版商:OVID    

年代:1984

数据来源: OVID

ISSN:0273-8481    

出版商:OVID    

年代:1984

数据来源: OVID

ISSN:0273-8481    

出版商:OVID    

年代:1984

数据来源: OVID

ISSN:0273-8481    

出版商:OVID    

年代:1984

数据来源: OVID

ISSN:0273-8481    

出版商:OVID    

年代:1984

数据来源: OVID

摘要:

In an attempt to prevent renal damage due to hemoglobinuria, haptoglobin preparations were administered to patients with extensive third-degree burns.In a patient (Case 1) with 58% BSA burn who did not receive haptoglobin, serum free hemoglobin was 326 mg/dl one hour postburn and free haptoglobin had been depleted. There was marked hemoglobinuria, urine hemoglobin being 123 mg/dl. The patient became oliguric six hours postburn and died of acute renal failure.Case 2 also showed hemoglobinuria and serum free haptoglobin depletion. Haptoglobin administration resulted in the disappearance of hemoglobinuria associated with an elevation of free haptoglobin. Case 3 received haptoglobin immedately after burn and hemoglobinuria was prevented.It appears that the maintenance of serum free haptoglobin levels by exogenous haptoglobin administration excludes a contributing cause, hemoglobinuria, in the development of postburn renal failure.

ISSN:0273-8481    

出版商:OVID    

年代:1984

数据来源: OVID

摘要:

Burn injuries cause dynamic alterations in the coagulative and fibrinolytic activities of the blood, but there have been relatively few detailed studies on anticoagulative therapies for burned patients. The clinical significance of heparin therapy in animal experiments and clinical experience was studied.We induced deep burns on 40% of the TBSA in rabbits and followed the hematologic alterations. In rabbits that received no therapy, platelet counts and fibrinogen and plasminogen levels decreased gradually after injury, and levels of fibrin degradation products (FDP) increased soon after injury. In rabbits given only infusion therapy, almost the same alterations took place as in nontreated rabbits. However, in rabbits administered heparin in addition to infusion therapy, there were significant alterations: no decrease in platelet counts, a slight decrease in fibrinogen levels, and no increase in FDP levels. Results of the animal experiments showed that disseminated intravascular coagulation (DIC) may occur soon after injury but may be prevented by immediate use of heparin.Clinical administration of heparin in doses of 10,000–20,000 units a day prevented DIC and did not produce undesirable side effects. In severely burned patients, however,– the therapeutic effect of heparin was underestimated because of the considerable decrease in antithrombin III concentration. Therefore, we recommend that an incrassated preparation of AT III and heparin be used synchronously in severely burned patients.

ISSN:0273-8481    

出版商:OVID    

年代:1984

数据来源: OVID

摘要:

Blood heated to 58 C for 60 seconds, cooled to 37 C and perfused via mesenteric arteries in dogs causes marked increase in permeability to fluorescein-tagged dextrans. Plasma heated in the absence of erythrocytes cause no increase in permeability, but plasma separated from previously heated blood causes an increase in permeability equal to that produced by heat-treated blood. Erythrocytes added to Ringer's solution and heated to 58 C for 60 seconds, when cooled and perfused, also cause increased permeability.Based upon these observations, we hypothesize that increase in permeability in microvessels not directly damaged by heat is caused, at least in part, by a factor, EDPF (eryth-rocyte-derived permeability factor), released from membranes of erythrocytes after exposure to abnormal temperatures. We also postulate that EDPF is an important etiologic factor in subsequent deterioration of cutaneous tissues that were still viable immediately after burn trauma.

ISSN:0273-8481    

出版商:OVID    

年代:1984

数据来源: OVID

摘要:

Allograft differs from other biologic dressings in its good take, similar to that of autograft. Nevertheless, eventual rejection is inevitable. Clinical indications and effects of allograft, based on clinical experience, are discussed. Effects addressed are improvement in general condition of the patient, pain alleviation, prevention of infection, temporary wound closure, and epithelial proliferation. It is concluded that one can expect good local and systemic effects of allograft in third-degree burns in which rejection does not result in destruction of cutaneous tissues. However, allograft applied to second-degree burns will subsequently destroy dermal tissues to some extent by rejection. It is difficult, at least in principle, to expect enhancement of reepithelialization in these burns.

ISSN:0273-8481    

出版商:OVID    

年代:1984

数据来源: OVID