ISSN:1660-5527    

DOI:10.1159/000210745

出版商:S. Karger AG    

年代:1988

数据来源: Karger

摘要:

A new method (Pain-Track®) for recording subjective symptoms was evaluated for its capacity to quantify clinical itch. The Pain-Track system includes portable data loggers carried by the patients, a personal computer with a software package for storage and analysis of the data and a terminal unit to connect the loggers and computer. Every 60 min a signal from the logger commands the patient to mark his presence and rate the itch intensity. During night time the hourly buzz can be turned off but the intensity rate can be adjusted whenever wanted. The antipruritic effect of betamethasone dipropionate and its cream base was studied according to a double-blind, crossover protocol in 30 adult outpatients with atopic dermatitis, 26 of whom completed the study. Analysis with parametric and nonparametric methods showed that the itch intensity was significantly lower during active treatment than with placebo. Onset of the antipruritic action was rapid. Examination of the ‘itch profile’ revealed that atopies have more intense itch both in the mornings and evenings than during the day. It is concluded that by using a drug with known antipruritic effect we have shown that Pain-Track is a useful tool for assessing clinical pruritus and the antipruritic effects of drugs. The main advantages are possibilities for frequent recordings, surveillance of compliance improving authenticity, and storage and analysis of a large amount of data.

ISSN:1660-5527    

DOI:10.1159/000210746

出版商:S. Karger AG    

年代:1988

数据来源: Karger

摘要:

Chemical substances migrate outwards from within the body to the skin surface by diffusion from cutaneous capillaries across the epidermis. Heretofore, study of transepidermal chemical emissions have been restricted to substances which are in the vapor phase at skin surface temperature. We have investigated outward transcutaneous chemical migration of nongaseous chemicals by devising an occlusive transcutaneous chemical collection system, consisting of a tape-encased plug of gelled saline in which activated carbon is dispersed. Investigations of nine chemicals in ‘fuzzy’ rats, rhesus monkeys, and man provide data which are consistent with a general theory of outward transcutaneous chemical migration. This noninvasive continuous transcutaneous sampling technique provides a new method for investigating skin permeability in vivo and may provide a basis for convenient diagnosis and monitoring of chemical exposure.

ISSN:1660-5527    

DOI:10.1159/000210747

出版商:S. Karger AG    

年代:1988

数据来源: Karger

摘要:

Several biochemical parameters including ornithine decarboxylase activity (ODC) and tissue polyamine levels were measured during the hexadecane-induced epidermal hyperplasia of hairless rat skin. Animals received three applications of 200 μ1 pure n-hexadecane on day 1. ODC activity and polyamine levels (putrescine, spermidine and spermine) in the epidermis were significantly increased and reached maximum elevations at 12 h after the start of n-hexadecane treatment with DNA synthesis peaking at 24 h. Histological studies confirmed a significant cellular edema at 24 h after the beginning of the treatment followed at 48 h by an epidermal hyperplasia which was maximum at 72 h. These data support the view that ODC activation, increased biosynthesis of polyamines and DNA are early events in epidermal cell hyperproliferation.

ISSN:1660-5527    

DOI:10.1159/000210748

出版商:S. Karger AG    

年代:1988

数据来源: Karger

摘要:

The proinflammatory effects of recombinant human interleukin-1α (HRIL-1α) have been determined in the skin of normal human volunteers. Intradermal injection of 10, 50 and 100 U HRIL-1α produced dose-related erythema which first appeared at 2 h, was maximal around 24 h, persisted for up to 48 h, and was associated with oedema. Histological examination revealed dermal mononuclear cell infiltrates, which were accompanied by neutrophils at 4 and 8 h. Injection of heat-treated HRIL-1α (100 U) produced no erythema or oedema. These results demonstrate the potent proinflammatory properties of HRIL-1α in human skin.

ISSN:1660-5527    

DOI:10.1159/000210749

出版商:S. Karger AG    

年代:1988

数据来源: Karger

ISSN:1660-5527    

DOI:10.1159/000210750

出版商:S. Karger AG    

年代:1988

数据来源: Karger

ISSN:1660-5527    

DOI:10.1159/000316414

出版商:S. Karger AG    

年代:1988

数据来源: Karger

ISSN:1660-5527    

DOI:10.1159/000316415

出版商:S. Karger AG    

年代:1988

数据来源: Karger

ISSN:1660-5527    

DOI:10.1159/000210751

出版商:S. Karger AG    

年代:1988

数据来源: Karger