ISSN:0268-9146    

DOI:10.1111/j.1365-2052.1996.tb01585.x

出版商:Blackwell Publishing Ltd    

年代:1996

数据来源: WILEY

ISSN:0268-9146    

DOI:10.1111/j.1365-2052.1996.tb02845.x

出版商:Blackwell Publishing Ltd    

年代:1996

数据来源: WILEY

摘要:

SummaryBulked co‐segregant analysis is a method of rapidly allocating unmapped genetic markers to a specific chromosomal region. Although originally developed for utilization in populations derived from crosses between fully inbred lines, it has been proposed that co‐segregant pools could also serve the same purpose in outbreeding populations, if individuals from only a single large family are pooled. Large, fully mapped, single‐sire backcross and half‐sib families are presently available as part of the international chicken and bovine reference family panels respectively. In this study, power and tests of significance for single‐parent co‐segregant analysis are derived for full‐sib, single‐parent back‐cross and single‐parent half‐sib families, as a function of proportion of recombination between index marker and linked marker, proportion of single‐parent alleles among the mates, number of individuals in each segregant pool and technical error variance. Power was found to be greater than 0–80 for many reasonable parameter combinations. The method is illustrated using microsatellite markers and a large single‐sire bovine family, part of the international bo

ISSN:0268-9146    

DOI:10.1111/j.1365-2052.1996.tb01171.x

出版商:Blackwell Publishing Ltd    

年代:1996

数据来源: WILEY

ISSN:0268-9146    

DOI:10.1111/j.1365-2052.1996.tb02846.x

出版商:Blackwell Publishing Ltd    

年代:1996

数据来源: WILEY

ISSN:0268-9146    

DOI:10.1111/j.1365-2052.1996.tb02847.x

出版商:Blackwell Publishing Ltd    

年代:1996

数据来源: WILEY

ISSN:0268-9146    

DOI:10.1111/j.1365-2052.1996.tb02848.x

出版商:Blackwell Publishing Ltd    

年代:1996

数据来源: WILEY

ISSN:0268-9146    

DOI:10.1111/j.1365-2052.1996.tb02849.x

出版商:Blackwell Publishing Ltd    

年代:1996

数据来源: WILEY

摘要:

SummaryThe DNA sequences of the control region of the mitochondrial genome of fifty unrelated sheep were determined in order to ascertain the extent and distribution of its variability. A consensus sequence was derived, and 1081 differences from it were observed amongst the fifty animals. Some constant groups of differences were observed that were held in common by a number of animals, which thus fell into two main groups, although neither group was typical of anyof the breeds sampled. The consensus sequence also allowed comparison between the control region sequences of sheep and other mammals. The sequence contains four tandem repeats of a 75 base‐pair motif that accounts for the difference in its size from the cattle control region, to which it is otherwise very similar. Comparison with the cattle sequence allowed the determination of the homologues of various functionally important sites. The homologues of the transcription promoters, the origin of replication and the central conserved sequence block were all identified by this metho

ISSN:0268-9146    

DOI:10.1111/j.1365-2052.1996.tb01173.x

出版商:Blackwell Publishing Ltd    

年代:1996

数据来源: WILEY

ISSN:0268-9146    

DOI:10.1111/j.1365-2052.1996.tb02850.x

出版商:Blackwell Publishing Ltd    

年代:1996

数据来源: WILEY

ISSN:0268-9146    

DOI:10.1111/j.1365-2052.1996.tb02851.x

出版商:Blackwell Publishing Ltd    

年代:1996

数据来源: WILEY